INT92056

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.75
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) extracellular region (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
macrophages 3
lymphocytes 1
peritoneal macrophages 1
respiratory 1
Il12b (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 99.70 Very High Very High Very High
chemokine 30 99.16 Very High Very High Very High
cytokine 197 96.76 Very High Very High Very High
Inflammation 59 93.60 High High
addiction 1 86.36 High High
interstitial cystitis 41 81.84 Quite High
opioid receptor 1 70.64 Quite High
Inflammatory mediators 2 52.92 Quite High
Inflammatory response 4 39.84 Quite Low
Inflammatory stimuli 1 18.56 Low Low
Disease Link Frequency Relevance Heat
Infection 346 99.92 Very High Very High Very High
Cancer 14 99.80 Very High Very High Very High
Necrosis 12 99.56 Very High Very High Very High
Mycobacterial Infection 339 99.28 Very High Very High Very High
Cold Sores 214 96.96 Very High Very High Very High
INFLAMMATION 63 93.60 High High
Repression 43 92.88 High High
Chlamydia Infection 67 90.40 High High
Sprains And Strains 78 87.92 High High
Interstitial Cystitis 41 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine enhanced mRNA expression of interleukin (IL)-12 p40 and tumor necrosis factor alpha (TNF-alpha) compared with controls, whereas IL-10 levels were unchanged by drug treatment.
Transcription (expression) of p40 associated with necrosis, cancer and morphine
1) Confidence 0.69 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.27 Pain Relevance 0.99
Transcription of the IL-12p40 gene in macrophages requires de novo protein synthesis during the inducing HSV infection, which could explain the relatively late appearance of IL-12 production [238,367].
Transcription (Transcription) of IL-12p40 in macrophages associated with cold sores and infection
2) Confidence 0.21 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.13 Pain Relevance 0.08
Parthenolide had no inhibitory effect on IL-6 mRNA levels in LPS-stimulated macrophages, but did attenuate IL-12 p40 and p35 mRNA expression [14] as well as the chemokine IL-8 in cultured human respiratory epithelium [15].
Transcription (expression) of IL-12 p40 in respiratory associated with chemokine
3) Confidence 0.10 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.35 Pain Relevance 0.38
and IL-12p40 mRNA expression by urinary bladder lymphocytes from mice challenged with CYP and treated with anti-CXCL10 Ab, than compared to control Ab-treated mice.
Transcription (expression) of IL-12p40 in lymphocytes
4) Confidence 0.08 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.80 Pain Relevance 0.31
To identify the M. tuberculosis genes responsible for this aspect of immune evasion, we used a macrophage cell line expressing a reporter for IL-12p40 transcription to screen a transposon library of M. tuberculosis for mutants that lacked this function.
Transcription (transcription) of IL-12p40 in macrophage associated with mycobacterial infection
5) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2390761 Disease Relevance 0.59 Pain Relevance 0
To explore the hypothesis that the low levels of IL-12p40 produced by macrophages infected with M. tuberculosis resulted from active inhibition of IL-12p40 transcription, we used the reporter cell line to screen for mutant bacilli that had lost this function.
Transcription (transcription) of IL-12p40 in macrophages associated with mycobacterial infection
6) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.68 Pain Relevance 0.05
Previously, Oswald et al. reported that peritoneal macrophages isolated from mice showed activation of transcription of IL-12p40 ex vivo when treated with TDM purified from M. tuberculosis [40].
Transcription (transcription) of IL-12p40 in peritoneal macrophages associated with mycobacterial infection
7) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.23 Pain Relevance 0
IL-12p40 mRNA expression coincided with CCL5, but typically preceded IFN-?
Transcription (expression) of IL-12p40
8) Confidence 0.01 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.70 Pain Relevance 0.13

General Comments

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