INT9206

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.41
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ID1) cytoplasm (ID1)
Anatomy Link Frequency
Temporomandibular joint 1
A2780 1
ID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 8 97.76 Very High Very High Very High
cINOD 3 93.88 High High
Pain 1 75.00 Quite High
COX2 1 25.00 Low Low
psoriasis 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 100.00 Very High Very High Very High
Aging 1 98.88 Very High Very High Very High
Cancer 33 98.04 Very High Very High Very High
Temporomandibular Joint Syndrome 8 97.76 Very High Very High Very High
Ovarian Cancer 1 97.28 Very High Very High Very High
Stomach Cancer 12 97.20 Very High Very High Very High
Psoriasis 5 90.96 High High
Colon Cancer 14 88.12 High High
INFLAMMATION 3 75.00 Quite High
Pain 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Id-1 gene downregulation by sulindac sulfide and its upregulation during tumor development in gastric cancer.
Negative_regulation (downregulation) of Id-1 associated with cancer and stomach cancer
1) Confidence 0.59 Published 2006 Journal Int. J. Cancer Section Title Doc Link 16184548 Disease Relevance 0.46 Pain Relevance 0.09
Id-1 expression level was decreased dose-dependently by sulindac sulfide.
Negative_regulation (decreased) of Id-1
2) Confidence 0.59 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16184548 Disease Relevance 0.53 Pain Relevance 0.08
Temporomandibular joint internal derangement (TMJ ID) is the most common intra-articular TM disorder and can progress from TMJ ID with reduction to TMJ ID without reduction.
Negative_regulation (reduction) of TMJ ID in Temporomandibular joint associated with snapping jaw
3) Confidence 0.29 Published 1992 Journal J. Dent. Res. Section Abstract Doc Link 1401443 Disease Relevance 0.55 Pain Relevance 0.55
The cell cycle blockade and differentiation caused by such a drug, trichostatin A, caused decreased levels of ID-1 consistent with cell cycle senescence and differentiation of A2780 ovarian cancer cells [17].
Negative_regulation (decreased) of ID-1 in A2780 associated with aging and ovarian cancer
4) Confidence 0.27 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.29 Pain Relevance 0
Promoter studies indicated that c-Myb can activate COX-2 transcription, whereas dominant-negative Myb mediated repression.
Negative_regulation (repression) of dominant-negative Myb associated with repression
5) Confidence 0.04 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10766162 Disease Relevance 0.58 Pain Relevance 0.07

General Comments

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