INT9207

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.34
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINB2) extracellular region (SERPINB2) Golgi apparatus (SERPINB2)
plasma membrane (SERPINB2) cytoplasm (SERPINB2)
Anatomy Link Frequency
extracellular matrix 2
sciatic nerve 1
SERPINB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 1 98.76 Very High Very High Very High
Sciatic nerve 1 98.00 Very High Very High Very High
cytokine 10 97.22 Very High Very High Very High
Peripheral nerve injury 1 75.00 Quite High
Root ganglion neuron 1 75.00 Quite High
alcohol 4 68.32 Quite High
anesthesia 12 62.24 Quite High
Angina 2 50.00 Quite Low
Inflammation 12 25.36 Quite Low
neuralgia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 98.76 Very High Very High Very High
Cancer 24 92.88 High High
Malignant Neoplastic Disease 4 80.72 Quite High
Injury 23 77.20 Quite High
Liver Cancer 4 76.92 Quite High
Colon Cancer 4 76.00 Quite High
Benign Tumor 2 75.84 Quite High
Metastasis 8 75.16 Quite High
Nervous System Injury 2 75.00 Quite High
Ganglion Cysts 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Urokinase decreased filling defects at 15 min after angioplasty in comparison with placebo (14% vs. 29%, respectively, p = 0.08).
Negative_regulation (decreased) of Urokinase
1) Confidence 0.38 Published 1992 Journal J. Am. Coll. Cardiol. Section Body Doc Link 1401622 Disease Relevance 0.07 Pain Relevance 0
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Negative_regulation (inhibitors) of PAI2 in extracellular matrix associated with cytokine
2) Confidence 0.21 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.94 Pain Relevance 0.15
Here we examined whether the plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) mRNA, endogenous inhibitors of tPA and uPA, are induced in the DRG following sciatic nerve transection.
Spec (whether) Negative_regulation (inhibitors) of plasminogen activator inhibitor-1 and -2 in sciatic nerve associated with sciatic nerve
3) Confidence 0.15 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780477 Disease Relevance 0.40 Pain Relevance 0.22
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Negative_regulation (inhibitors) of PAI2 in extracellular matrix associated with cytokine
4) Confidence 0.07 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.94 Pain Relevance 0.15

General Comments

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