INT92075

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 2
Speculated 6
Reported most in Body
Documents 12
Total Number 17
Disease Relevance 16.18
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTM1) small molecule metabolic process (GSTM1) cytoplasm (GSTM1)
Anatomy Link Frequency
coronary artery 2
neurons 1
lung 1
GSTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 9 100.00 Very High Very High Very High
mu opioid receptor 4 100.00 Very High Very High Very High
Pyramidal cell 2 99.16 Very High Very High Very High
Morphine 6 98.90 Very High Very High Very High
Inflammation 99 97.96 Very High Very High Very High
melanocortin 1 receptor 8 90.44 High High
Inflammatory marker 6 89.84 High High
opiate 2 78.28 Quite High
orphanin 4 75.00 Quite High
Opioid 3 74.00 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 597 99.64 Very High Very High Very High
Coronary Artery Disease 397 99.32 Very High Very High Very High
Skin Cancer 7 99.20 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

25 99.10 Very High Very High Very High
Diabetes Mellitus 51 98.82 Very High Very High Very High
Disease 70 98.64 Very High Very High Very High
Hypertension 47 98.62 Very High Very High Very High
Colon Cancer 99 98.28 Very High Very High Very High
Nevus 1 98.16 Very High Very High Very High
INFLAMMATION 115 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no effect of homozygous GST M1 or T1 deletions on melanoma risk.
Neg (no) Regulation (effect) of GST M1 associated with skin cancer
1) Confidence 0.50 Published 2007 Journal Arch. Dermatol. Res. Section Abstract Doc Link 17072629 Disease Relevance 0.81 Pain Relevance 0.42
The relation of GSTM1/T1 gene polymorphism to coronary artery disease
Regulation (relation) of GSTM1/T1 gene in coronary artery associated with coronary artery disease
2) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.12 Pain Relevance 0
As we considered the effect of GSTM1/GSTT1 genotype on the multivessel disease, there was no significant difference in GSTM1/GSTT1 genotype in relation to the number of involved vessel in both smokers and non-smokers (Table 7).
Regulation (effect) of GSTM1 associated with nicotine addiction and disease
3) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.27 Pain Relevance 0
To analyze the effect of GSTM1/T1 gene polymorphisms on the development of smoking-related coronary artery disease (CAD), 775 Korean patients who underwent coronary angiography were enrolled.
Spec (analyze) Regulation (effect) of GSTM1/T1 gene in coronary artery associated with coronary artery disease and nicotine addiction
4) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2526535 Disease Relevance 0.71 Pain Relevance 0
After adjusting other coronary risk factors such as hypertension, diabetes, dyslipidemia, age, and sex than smoking, the interactive effect GSTM1/GSTT1 gene and smoking on CAD remained statistically significant (in smokers with GSTM1 null genotype, OR, 2.01, CI, 1.13-3.69, p=0.01/in smokers with GSTT1 null genotype, OR, 1.89, CI, 1.03-3.13, p=0.02) (Table 5, 6).
Regulation (effect) of GSTM1 associated with coronary artery disease, nicotine addiction, diabetes mellitus and hypertension
5) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.23 Pain Relevance 0
Also, there was no significant effect of GSTM1/GSTT1 genotype on the severity of CAD (Table 8).
Neg (no) Regulation (effect) of GSTM1 associated with coronary artery disease
6) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.43 Pain Relevance 0
These results also suggest that GSTM1 and GSTP1 gene polymorphisms may be involved in the detoxification of toxic substances in cigarette smoke to change the levels of TNF-?
Regulation (polymorphisms) of GSTM1
7) Confidence 0.45 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 1.04 Pain Relevance 0.23
In their study, when the effects of combined GSTM1 and GSTP1 genotypes on DNA adduct formation were examined, lung cancer patients with GSTM1 null and GSTP1 AG or GG genotype combinations had significantly higher carcinogen-derived DNA adduct level in lung tissue than those with the other genotype combinations.
Spec (examined) Regulation (effects) of GSTM1 in lung associated with lung cancer
8) Confidence 0.45 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.86 Pain Relevance 0.23
The variables showing an association (p < .05) in Table 2 were then put into a stepwise multiple logistic regression, in order to study the possible combined effect of the GSTT1 plus GSTM1 haplotype with other risk factors on CAD manifestation.
Spec (possible) Regulation (effect) of GSTM1 associated with coronary artery disease
9) Confidence 0.43 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.74 Pain Relevance 0
Therefore, our aim is to investigate the possible relevance of the GSTM1 and GSTT1 polymorphisms either individually or combined (haplotype) on the development of CAD.
Spec (possible) Regulation (relevance) of GSTM1 associated with coronary artery disease
10) Confidence 0.43 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.48 Pain Relevance 0
Our analyses also showed a protective effect of the variant GSTM1 null carried at the heterozygous state on CRC risk.
Regulation (effect) of GSTM1 associated with colon cancer
11) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.50 Pain Relevance 0
In animal and cell culture experiments, chronic morphine treatment has been followed by 'up'- as well as 'down-regulation' of the mu opioid receptor (mu OR) number.
Regulation (regulation) of mu OR associated with mu opioid receptor and morphine
12) Confidence 0.10 Published 2001 Journal Forensic Sci. Int. Section Abstract Doc Link 11074177 Disease Relevance 0.07 Pain Relevance 0.44
In both collectives, the anti-mu OR immunoreactivity was mainly found in pyramidal neurons of layers (L) II/III and V and in multiform neurons of L VI.
Regulation (immunoreactivity) of mu OR in neurons associated with pyramidal cell
13) Confidence 0.09 Published 2001 Journal Forensic Sci. Int. Section Abstract Doc Link 11074177 Disease Relevance 0.07 Pain Relevance 0.47
The possible involvement of host genotype, particularly as it relates to immuno-phenotype, has been frequently postulated as a major influence on GTM composition and stability although this has been difficult to prove.
Spec (postulated) Regulation (influence) of GTM
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798964 Disease Relevance 0.06 Pain Relevance 0.03
Other environmental variables may significantly influence the composition of the GTM, including antibiotic use where it has for example been shown that oral ciprofloxacin dosing alters the abundance of approximately one third of GTM taxa, decreasing the richness and diversity with profiles returning to re-treatment states for most taxa 4 weeks after the end of treatment [35].
Spec (may) Regulation (influence) of GTM
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798964 Disease Relevance 0.13 Pain Relevance 0
In order to test if the MNS activity could be a biomarker of empathy, a Pearson r correlation coefficient (two-tailed) was calculated for each mu suppression value at each observed condition with her/his dispositional measures of empathy.
Regulation (value) of mu
16) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361218 Disease Relevance 0 Pain Relevance 0.03
These observations support a role for cAMP in regulating MuOR responsiveness through actions at the level of receptor gene expression.
Regulation (regulating) of MuOR associated with opioid receptor
17) Confidence 0.01 Published 2002 Journal Brain Res. Section Abstract Doc Link 12106667 Disease Relevance 0.19 Pain Relevance 0.41

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