INT921

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Context Info
Confidence 0.60
First Reported 1976
Last Reported 2011
Negated 26
Speculated 5
Reported most in Abstract
Documents 172
Total Number 177
Disease Relevance 52.88
Pain Relevance 51.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1) extracellular region (GH1)
Anatomy Link Frequency
plasma 17
pituitary 14
PES 2
outflow 2
central nervous system 2
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 258 100.00 Very High Very High Very High
narcan 111 100.00 Very High Very High Very High
anesthesia 25 100.00 Very High Very High Very High
Enkephalin 22 100.00 Very High Very High Very High
epidural 8 100.00 Very High Very High Very High
fluoxetine 8 100.00 Very High Very High Very High
analgesia 4 100.00 Very High Very High Very High
opiate 66 99.98 Very High Very High Very High
Opioid 51 99.98 Very High Very High Very High
Central nervous system 10 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 52 100.00 Very High Very High Very High
Renal Failure 20 99.84 Very High Very High Very High
Turner's Syndrome 71 99.80 Very High Very High Very High
Chronic Fatigue Syndrome 68 99.76 Very High Very High Very High
Pituitary Cancer 251 99.56 Very High Very High Very High
Acromegaly 610 99.54 Very High Very High Very High
Obesity 309 99.52 Very High Very High Very High
Diabetes Mellitus 130 99.52 Very High Very High Very High
Hypercalcemia 8 99.52 Very High Very High Very High
Panic Disorder 12 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of placebo did not change plasma GH levels in any subject.
Neg (not) Regulation (change) of GH in plasma
1) Confidence 0.60 Published 1995 Journal Metab. Clin. Exp. Section Abstract Doc Link 8786727 Disease Relevance 0.30 Pain Relevance 0.42
These data show that alcoholism is associated with an impairment in the serotonergic-stimulatory regulation of GH secretion, whereas GH responses to direct pituitary stimulation with GHRH or to release from somatostatinergic inhibition with arginine appear to be preserved in alcoholics.
Regulation (responses) of GH in pituitary associated with alcohol addiction
2) Confidence 0.60 Published 1995 Journal Metab. Clin. Exp. Section Abstract Doc Link 8786727 Disease Relevance 0.24 Pain Relevance 0.40
In the 14 acromegalic patients studied, the GHRH-induced GH net increase was similar to that observed in controls, while the placebo did not alter GH basal levels.
Neg (not) Regulation (alter) of GH
3) Confidence 0.60 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8284031 Disease Relevance 0.14 Pain Relevance 0.44
We conclude that alpha adrenoreceptor mechanisms are of major importance while opiate receptor mechanisms are of relatively minor importance in modulating the effects of glucoprivation on sympathetic outflow and hPP, GH, and PRL levels.
Regulation (modulating) of GH in outflow associated with opiate
4) Confidence 0.60 Published 1985 Journal Metab. Clin. Exp. Section Abstract Doc Link 3982277 Disease Relevance 0 Pain Relevance 0.66
Naloxone influence on the growth hormone, prolactin and thyrotropin response to thyrotropin releasing hormone in acromegalic patients.
Regulation (influence) of growth hormone associated with narcan
5) Confidence 0.60 Published 1996 Journal Exp. Clin. Endocrinol. Diabetes Section Title Doc Link 8750573 Disease Relevance 0 Pain Relevance 0.30
The effect of segmental epidural analgesia on maternal growth hormone, insulin, glucose and free fatty acids during labour.
Regulation (effect) of growth hormone associated with epidural and analgesia
6) Confidence 0.60 Published 1976 Journal Ann Chir Gynaecol Section Title Doc Link 1020905 Disease Relevance 0.17 Pain Relevance 0.48
The present study was designed to investigate the effects of neuraleptanesthesia (NLA) and enflurane (Ethane) anesthesia on plasma levels of growth hormone (GH) and prolactin (PRL) in man.
Spec (investigate) Regulation (effects) of GH in plasma associated with anesthesia
7) Confidence 0.53 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0 Pain Relevance 0.17
The management of her diabetes was also more effective (with fewer episodes of severe hypoglycaemia) when her GH and IGF-1 levels were controlled.
Regulation (controlled) of GH associated with hypoglycemia and diabetes mellitus
8) Confidence 0.48 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.77 Pain Relevance 0.09
These data provide good indirect evidence for coregulation of the GH-BP with both sex steroids and gonadotropins.
Regulation (coregulation) of GH-BP
9) Confidence 0.45 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1430084 Disease Relevance 0.13 Pain Relevance 0.05
GH-BP levels did not change significantly in response to 0.15 mg Clonidine ingestion.
Regulation (change) of GH-BP associated with clonidine
10) Confidence 0.45 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1430084 Disease Relevance 0.24 Pain Relevance 0.18
DT completely blunted the GH response to ARG, whereas it attenuated the GH response to GAL, but not at a statistically significant level.
Regulation (response) of GH
11) Confidence 0.44 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8570858 Disease Relevance 0 Pain Relevance 0.21
Before the meal, NAL completely abolished the response of GH to PYR in men (AUC, 1,031.06 +/- 333.21 v 16.50 +/- 7.50 micrograms/L/90 min, P < .01), whereas infusion of NAL did not significantly modify the GH response to PYR in women.
Regulation (response) of GH associated with narcan
12) Confidence 0.44 Published 1997 Journal Metab. Clin. Exp. Section Abstract Doc Link 9225825 Disease Relevance 0 Pain Relevance 0.49
This study shows that the effect of D on PRL and GH secretion can be dissociated in patients with PRL-secreting pituitary adenoma, perhaps for a different derangement in the hypothalamic-pituitary mechanism(s) underlying the opioidergic regulation of GH and PRL secretion.
Regulation (regulation) of GH in pituitary associated with pituitary cancer
13) Confidence 0.44 Published 1985 Journal Metab. Clin. Exp. Section Abstract Doc Link 4033428 Disease Relevance 0.56 Pain Relevance 0.24
Effects of a met-enkephalin analog on adrenocorticotropin (ACTH), growth hormone, and prolactin in patients with ACTH hypersecretion.
Regulation (Effects) of growth hormone associated with enkephalin
14) Confidence 0.44 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6281297 Disease Relevance 0.74 Pain Relevance 0.35
Compounds thought to inhibit hypothalamic somatostatin (SRIH) release (pyridostigmine, arginine, galanin, atenolol) consistently improve, though do not normalize, the somatotropin response to GHRH in obesity.
Regulation (response) of somatotropin associated with obesity and somatostatin
15) Confidence 0.44 Published 1999 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 10193871 Disease Relevance 0.57 Pain Relevance 0.19
The pineal gland-opioid system relation: melatonin-naloxone interactions in regulating GH and LH releases in man.
Regulation (regulating) of GH in pineal gland associated with narcan and opioid
16) Confidence 0.41 Published 1988 Journal J. Endocrinol. Invest. Section Title Doc Link 3361078 Disease Relevance 0 Pain Relevance 0.73
The present study aimed to assess the influence of long-term rhEPO therapy on baseline and stimulated GH concentrations in a group of uremic patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
Regulation (influence) of GH associated with renal failure and uremia
17) Confidence 0.41 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10024084 Disease Relevance 1.04 Pain Relevance 0.06
The lack of change in pituitary hormone secretion by loperamide is in agreement with previous observations indicating that opiate effects on PRL, GH and gonadotropins occur at the level of the central nervous system.
Regulation (effects) of GH in central nervous system associated with central nervous system and opiate
18) Confidence 0.41 Published 1981 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6797827 Disease Relevance 0.06 Pain Relevance 0.52
The clinical significance of the difference in ADH and GH responses during fentanyl and during alfentanil or sulfentanil anesthesia remains to be determined.
Regulation (responses) of GH associated with rapifen and anesthesia
19) Confidence 0.41 Published 1982 Journal Anesth. Analg. Section Abstract Doc Link 6461279 Disease Relevance 0.10 Pain Relevance 0.59
Insulin induced a clear-cut increase in plasma GH (F = 79.88; P less than 0.001) that was not affected by placebo, whereas it was significantly inhibited by oral clonidine (P less than 0.001 at 60, 90, and 120 min).
Neg (not) Regulation (affected) of GH in plasma associated with clonidine
20) Confidence 0.40 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2826526 Disease Relevance 0.08 Pain Relevance 0.53

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