INT9210

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 24
Speculated 18
Reported most in Body
Documents 166
Total Number 183
Disease Relevance 125.61
Pain Relevance 49.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 8
leukocytes 4
liver 3
fibroblasts 3
blood 3
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2339 100.00 Very High Very High Very High
cytokine 1814 100.00 Very High Very High Very High
rheumatoid arthritis 836 100.00 Very High Very High Very High
Inflammatory marker 154 100.00 Very High Very High Very High
Inflammatory mediators 142 100.00 Very High Very High Very High
cINOD 78 100.00 Very High Very High Very High
Catecholamine 31 100.00 Very High Very High Very High
Inflammatory stimuli 28 100.00 Very High Very High Very High
qutenza 24 100.00 Very High Very High Very High
Paracetamol 19 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2938 100.00 Very High Very High Very High
Disease 1160 100.00 Very High Very High Very High
Rheumatoid Arthritis 1048 100.00 Very High Very High Very High
Cancer 754 100.00 Very High Very High Very High
Stress 684 100.00 Very High Very High Very High
Infection 528 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 252 100.00 Very High Very High Very High
Necrosis 209 100.00 Very High Very High Very High
Apoptosis 122 100.00 Very High Very High Very High
Adhesions 118 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that an acute stress manipulation does not modulate IL-6 within this time frame.
Neg (not) Regulation (modulate) of IL-6 associated with stress
1) Confidence 0.62 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 14651947 Disease Relevance 0.71 Pain Relevance 0.55
One explanation for this could be the effect of aging, which may overwhelm the genetic effect on the IL-6 levels.
Regulation (effect) of IL-6 associated with aging
2) Confidence 0.62 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.90 Pain Relevance 0.40
While the effects of naproxen and meloxicam were small and restricted to protein synthesis, tenidap strongly inhibited IL-6 protein synthesis and also affected IL-6 mRNA levels.
Regulation (affected) of IL-6
3) Confidence 0.61 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.54 Pain Relevance 0.50
Benzodiazepine anesthesia in humans modulates the interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6 responses of blood monocytes.
Regulation (responses) of interleukin-6 in monocytes associated with necrosis, anesthesia and cancer
4) Confidence 0.60 Published 1991 Journal J. Neuroimmunol. Section Title Doc Link 1955561 Disease Relevance 0.47 Pain Relevance 0.46
We are able to describe relative but not absolute changes of IL-6 levels in response to pollution because we transformed the data to Z-scores in order to combine data from two separate studies.
Neg (not) Regulation (changes) of IL-6
5) Confidence 0.60 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.56 Pain Relevance 0.18
The potential implications of the findings of this study extend beyond demonstrating that ambient pollutant exposure has a significant effect on baseline systemic levels of IL-6.
Regulation (effect) of IL-6
6) Confidence 0.60 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.64 Pain Relevance 0.23
No clear effects on plasma inflammatory markers (C-reactive protein and interleukin-6) were observed.
Neg (No) Regulation (effects) of interleukin-6 in plasma
7) Confidence 0.56 Published 2006 Journal J. Occup. Environ. Med. Section Body Doc Link 16766921 Disease Relevance 0 Pain Relevance 0
Tocilizumab, a monoclonal antibody (mAb) specific for the IL-6 receptor (IL-6R) is the first biologic agent targeting IL-6 that has progressed to late phase clinical trials.


Regulation (targeting) of IL-6
8) Confidence 0.55 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.71 Pain Relevance 0.21
Dysregulation of IL-6 may provide an explanation for some of the common clinical manifestations associated with active RA, including fever, weight loss, fatigue, and poor appetite (Yoshizaki et al 1998).
Regulation (Dysregulation) of IL-6 associated with weight loss, rheumatoid arthritis, fatigue and fever
9) Confidence 0.55 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 1.24 Pain Relevance 0.25
Only one previous study has examined the effect of exercise on IL-6 levels, a precursor of CRP, and shown this to be increased pre and post-exercise in 20 patients with IC compared to 20 healthy controls [6].
Spec (examined) Regulation (effect) of IL-6 associated with restless leg syndrome
10) Confidence 0.51 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 1.13 Pain Relevance 0.88
Tissue levels of IL-1 beta and IL-6 were not affected after the 400mg dose but decreased significantly (44+/-32% and 38+/-13%) after the 800 mg dose.
Neg (not) Regulation (affected) of IL-6
11) Confidence 0.48 Published 2008 Journal Pain Section Abstract Doc Link 18396374 Disease Relevance 0.97 Pain Relevance 0.79
Hence, given the central role of IL-6 levels in inflammatory pathways and its continuous association with CHD risk, it warrants further investigation as a plausible potential therapeutic target.
Regulation (role) of IL-6 associated with inflammation and coronary heart disease
12) Confidence 0.45 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2288623 Disease Relevance 1.09 Pain Relevance 0.25
Group assignment did not differentially affect change in IL-6 over time, either before or after capsaicin.
Regulation (change) of IL-6 associated with qutenza
13) Confidence 0.45 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 14651947 Disease Relevance 0.72 Pain Relevance 0.57
BMI = body mass index; CI = confidence interval; DIP = distal interphalangeal; IL-6 = interleukin-6; LD = linkage disequilibrium; OA = osteoarthritis; OR = odds ratio; SNP = single nucleotide polymorphism.


Regulation (interval) of IL-6 in body associated with obesity and osteoarthritis
14) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 1.05 Pain Relevance 0.47
Two of the three patients who received maintenance IL-6 therapy had a persistent increase in platelet counts, during 3 and 12 months of IL-6 therapy, respectively.
Regulation (received) of IL-6 in platelet
15) Confidence 0.45 Published 1995 Journal Blood Section Abstract Doc Link 7538815 Disease Relevance 0.70 Pain Relevance 0
Effects of recombinant human interleukin-6 in cancer patients: a phase I-II study.
Regulation (Effects) of interleukin-6 associated with cancer and cytokine
16) Confidence 0.45 Published 1994 Journal Blood Section Title Doc Link 8068939 Disease Relevance 0.96 Pain Relevance 0.24
Effects of NSAIDs on IL-1 beta-induced IL-6 mRNA and protein synthesis in human astrocytoma cells.
Regulation (Effects) of IL-6 associated with anaplastic astrocytoma and cinod
17) Confidence 0.45 Published 1996 Journal Neuroreport Section Title Doc Link 8817534 Disease Relevance 0.65 Pain Relevance 0.50
There is evidence that muscular modifications appear to be associated with high levels of pro-inflammatory cytokines, especially IL-6 and TNF-?
Regulation (especially) of IL-6 associated with inflammation and cytokine
18) Confidence 0.44 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.83 Pain Relevance 0.38
For example, controlled human exposure studies using fine concentrated ambient particles (CAPs) have demonstrated changes in biomarkers associated with systemic inflammation, including IL-6 and fibrinogen (Gong et al. 2003, 2004, 2008; Petrovic et al. 2000).
Regulation (changes) of IL-6 associated with inflammation
19) Confidence 0.44 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.25 Pain Relevance 0.09
IL-6 responses tended to be higher in the spring and summer for O3 and in the summer for PM2.5.
Regulation (responses) of IL-6
20) Confidence 0.44 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0 Pain Relevance 0

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