INT92105

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Context Info
Confidence 0.71
First Reported 2000
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 47
Total Number 51
Disease Relevance 27.47
Pain Relevance 25.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 6
DRG 4
neuronal 3
spinal cord 2
Dendritic cells 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 348 100.00 Very High Very High Very High
member 8 10 100.00 Very High Very High Very High
Cannabinoid receptor 9 100.00 Very High Very High Very High
Cannabinoid 7 100.00 Very High Very High Very High
ASIC 11 99.92 Very High Very High Very High
trigeminal ganglion 589 99.84 Very High Very High Very High
Inflammation 309 99.78 Very High Very High Very High
Nerve growth factor 115 99.78 Very High Very High Very High
dorsal root ganglion 397 99.68 Very High Very High Very High
nociceptor 209 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 143 99.88 Very High Very High Very High
Ganglion Cysts 1330 99.84 Very High Very High Very High
INFLAMMATION 312 99.78 Very High Very High Very High
Cold Sores 408 99.64 Very High Very High Very High
Targeted Disruption 101 99.40 Very High Very High Very High
Pain 369 99.32 Very High Very High Very High
Hyperalgesia 293 99.28 Very High Very High Very High
Vomiting 13 99.28 Very High Very High Very High
Bordatella Infection 4 98.32 Very High Very High Very High
Hypercalcemia 3 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the increase in TRPV1 mRNA expression in TG in vivo mirrored that observed in DRG in vitro.
Transcription (expression) of TRPV1 associated with dorsal root ganglion and trigeminal ganglion
1) Confidence 0.71 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.31 Pain Relevance 0.83
In DRG injected with the HSV-U6shLacZ vector, TRPV1 mRNA levels were essentially unchanged compared to the right DRG.
Transcription (levels) of TRPV1 associated with dorsal root ganglion and cold sores
2) Confidence 0.69 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.57 Pain Relevance 0.47
Our results demonstrate a significant reduction in Trpv1 mRNA levels in sensory neurons from mice injected with the vector expressing shTRPV1 and 59% reduction in TrpV1 protein levels following injection of the vector expressing miR-TRPV1.
Transcription (levels) of Trpv1 in sensory neurons
3) Confidence 0.69 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 0.84 Pain Relevance 0.29
Quantitative RT-PCR revealed that TRPV1 mRNA levels in the DRG of animals injected with HSV-U6shTRPV1 were reduced by 53.6 ± 11.2% (mean ± SD) compared to the right DRG.
Transcription (levels) of TRPV1 associated with dorsal root ganglion and cold sores
4) Confidence 0.69 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.56 Pain Relevance 0.49
A major difference between those studies and the current one is that they were carried out in rat, where the distribution of TRPV1 is quite different than in mouse.
Transcription (distribution) of TRPV1
5) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.45 Pain Relevance 0.11
We show that cisplatin-treated mice developed heat hyperalgesia along with robustly increased levels of TRPV1 mRNA expression in TG, with no change in the proportion of TRPV1 immunopositive neurons.
Transcription (expression) of TRPV1 in neurons associated with hyperalgesia and trigeminal ganglion
6) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.30 Pain Relevance 0.82
In addition, RT-PCR of single nodose cell bodies, which had been retrogradely labeled from the upper gut, detected transcripts for TRPV1, TRPV2, TRPV4, TRPN1, and TRPM8 in a proportion of cells.
Transcription (detected) of TRPV1 in gut
7) Confidence 0.68 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14726308 Disease Relevance 0.16 Pain Relevance 0.34
With peripheral inflammation, the mRNA expression of TRPV1 and ASIC3 is increased in dorsal root ganglia (DRG) and sensitizes their responses [15-20].
Transcription (expression) of TRPV1 in DRG associated with inflammation
8) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.21 Pain Relevance 1.05
Is thermal nociception only sensed by the capsaicin receptor, TRPV1?
Transcription (sensed) of TRPV1 associated with nociception and qutenza
9) Confidence 0.65 Published 2009 Journal Anat Sci Int Section Title Doc Link 19562439 Disease Relevance 0.52 Pain Relevance 0.80
Responses to capsaicin, menthol, and cinnamaldehyde were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected.
Transcription (detected) of TRPV1 associated with qutenza and member 8
10) Confidence 0.64 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344381 Disease Relevance 0.28 Pain Relevance 0.67
Quantitative polymerase chain reaction showed very low levels of TRPA1 and TRPV1 mRNA but high levels of TRPV4 and TRPV2 mRNA.
Transcription (levels) of TRPV1
11) Confidence 0.61 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.25 Pain Relevance 0.13
Dendritic cells expressed mRNA for cannabinoid receptor 1 (CB(1)), cannabinoid CB(2) receptor, and vanilloid receptor 1 (TRPV1) and the addition of the G(i) inhibitor, pertussis toxin, completely attenuated suppression induced by 3 and 6 muM THC but not by 10 muM THC.
Transcription (expressed) of TRPV1 in Dendritic cells associated with bordatella infection, cannabinoid receptor, cannabinoid and delta-9-tetrahydrocannabinol
12) Confidence 0.60 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443217 Disease Relevance 0.27 Pain Relevance 0.86
Dendritic cells expressed mRNA for cannabinoid receptor 1 (CB(1)), cannabinoid CB(2) receptor, and vanilloid receptor 1 (TRPV1) and the addition of the G(i) inhibitor, pertussis toxin, completely attenuated suppression induced by 3 and 6 muM THC but not by 10 muM THC.
Transcription (expressed) of vanilloid receptor 1 in Dendritic cells associated with bordatella infection, cannabinoid receptor, cannabinoid and delta-9-tetrahydrocannabinol
13) Confidence 0.60 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443217 Disease Relevance 0.27 Pain Relevance 0.83
In addition, in a separate study in our laboratories no change in the number of TRPV1-positive cells following inflammation was observed (B.M.
Transcription (number) of TRPV1 associated with inflammation
14) Confidence 0.60 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.44 Pain Relevance 0.17
Coexpression of mRNA for TNFR1 and TRPV1 receptors [17] and colocalization of TNFR1 and TRPV1 immunoreactivity [29] in DRG neurons has been reported.
Transcription (Coexpression) of TRPV1 in neurons associated with dorsal root ganglion
15) Confidence 0.59 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2936303 Disease Relevance 1.68 Pain Relevance 1.29
We analysed the distribution of TRPV1 receptors in the ferret brainstem and, for comparison, the co-localization of CB1 and TRPV1 receptors in the mouse brainstem.
Spec (analysed) Transcription (distribution) of TRPV1 in brainstem associated with medulla
16) Confidence 0.57 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17459108 Disease Relevance 0.87 Pain Relevance 0.80
TRPV3, a channel transcribed from a gene adjacent to TRPV1 but lacking sensitivity to capsaicin was identified first as a thermosensitive channel (threshold 34–39°C) [34,35,64].
Transcription (transcribed) of channel associated with qutenza
17) Confidence 0.54 Published 2008 Journal Mol Pain Section Body Doc Link PMC2386863 Disease Relevance 0.10 Pain Relevance 0.22
In this study TRPV1 mRNA was hardly detectable in any of the tested tissues and only found at significant levels in basal ganglia and testis.
Transcription (detectable) of TRPV1 in testis
18) Confidence 0.54 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.04
Expression of shRNAs targeting TRPV1 in transgenic (tg) mice was proven by RNase protection assays, and TRPV1 downregulation was confirmed by reduced expression of TRPV1 mRNA and lack of receptor agonist binding in spinal cord membranes.
Transcription (expression) of TRPV1 in spinal cord associated with targeted disruption, agonist and spinal cord
19) Confidence 0.53 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249134 Disease Relevance 0.68 Pain Relevance 0.32
Coexpression of TRPV1 mRNA with P2Y2 mRNA, but not P2Y1 mRNA, was determined in the rat lumbar DRG using in situ hybridization histochemistry.
Transcription (mRNA) of TRPV1
20) Confidence 0.53 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.50 Pain Relevance 0.52

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