INT92108

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Context Info
Confidence 0.12
First Reported 2001
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.94
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Tubb3) intracellular (Tubb3) GTPase activity (Tubb3)
cytoplasm (Tubb3)
Anatomy Link Frequency
neuronal 2
skin 2
glial cell 1
Tubb3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
wide dynamic range 2 93.52 High High
Dorsal horn 4 92.76 High High
vanilloid receptor subtype 1 2 86.24 High High
Hyperalgesia 12 76.28 Quite High
Inflammation 12 75.76 Quite High
antagonist 4 72.96 Quite High
agonist 6 68.72 Quite High
withdrawal 2 66.40 Quite High
Glutamate 4 60.36 Quite High
intrathecal 2 51.52 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 24 85.08 High High
Nociception 14 84.56 Quite High
Pheochromocytoma 8 80.00 Quite High
Rheumatoid Arthritis 16 77.12 Quite High
Hyperalgesia 12 76.28 Quite High
INFLAMMATION 10 75.76 Quite High
Obesity 28 37.96 Quite Low
Cv General 4 Under Development 4 36.28 Quite Low
Demyelinating Disease 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Markers of neuronal or glial cell types, such as beta-tubulin III, GFAP, p75 and S-100 could not be detected in rat ADSC (not shown).


Neg (not) Gene_expression (detected) of beta-tubulin III in glial cell
1) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257969 Disease Relevance 0.06 Pain Relevance 0
The expression of beta-tubulin III, GFAP, S-100 and p75 were undetectable in neurosphere cells (not shown).
Gene_expression (expression) of beta-tubulin III
2) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257969 Disease Relevance 0 Pain Relevance 0
Immunofluorescent staining confirmed that 31 ± 6% of SH-SH5Y cells expressed neuronal marker beta-tubulin III after being cultured in CM from SC-like cells for 3 days (Figure 5D); in contrast, beta-tubulin III positive cells were very rare or no in control group (Figure 5C).


Gene_expression (expressed) of beta-tubulin III in neuronal
3) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257969 Disease Relevance 0.17 Pain Relevance 0
Immunostaining showed that 29 ± 6% and 22 ± 5% of the differentiated neurosphere cells were positive for neuronal marker beta-tubulin III (Figure 3F) and glial marker GFAP (Figure 3G), respectively.


Gene_expression (positive) of beta-tubulin III in neuronal
4) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257969 Disease Relevance 0.08 Pain Relevance 0
Immunohistochemical experiments revealed the co-expression of mGlu5 receptor protein and betaIII tubulin in skin from naive rats, indicating the constitutive expression of mGlu5 receptors on peripheral neurones.
Gene_expression (expression) of betaIII tubulin in skin
5) Confidence 0.03 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11077066 Disease Relevance 0.82 Pain Relevance 0.98
Immunohistochemical experiments revealed the co-expression of mGlu5 receptor protein and betaIII tubulin in skin from naive rats, indicating the constitutive expression of mGlu5 receptors on peripheral neurones.
Gene_expression (-) of betaIII tubulin in skin
6) Confidence 0.02 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11077066 Disease Relevance 0.82 Pain Relevance 0.98

General Comments

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