INT9211

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Context Info
Confidence 0.04
First Reported 1990
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.15
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gldc) lyase activity (Gldc) enzyme binding (Gldc)
cellular amino acid metabolic process (Gldc)
Anatomy Link Frequency
dorsal root 1
neurons 1
spinal cord 1
cerebral cortex 1
cerebellum 1
Gldc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 52 100.00 Very High Very High Very High
Glutamate 12 100.00 Very High Very High Very High
Spinal cord 13 98.48 Very High Very High Very High
cerebral cortex 3 97.48 Very High Very High Very High
Hippocampus 3 96.68 Very High Very High Very High
substance P 11 94.80 High High
dorsal root ganglion 1 91.68 High High
Calcitonin gene-related peptide 8 84.72 Quite High
spinal dorsal horn 2 75.00 Quite High
antagonist 4 65.52 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 91.68 High High
Generalized Anxiety Disorder 6 57.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of gamma-aminobutyric acid (GABA) and glycine (Gly) to modulate each other's release was studied in synaptosomes from rat spinal cord, cerebellum, cerebral cortex, or hippocampus, prelabeled with [3H]GABA or [3H]Gly and exposed in superfusion to Gly or to GABA, respectively.
Localization (release) of glycine in spinal cord associated with gaba, hippocampus, cerebral cortex and spinal cord
1) Confidence 0.04 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1402899 Disease Relevance 0 Pain Relevance 0.50
High-intensity repetitive electrical stimulation of a lumbar dorsal root produced a Ca2(+)-dependent increase in the basal release of Asp, Glu, glycine (Gly), serine (Ser), and threonine (Thr).
Localization (release) of glycine in dorsal root associated with glutamate
2) Confidence 0.03 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1693954 Disease Relevance 0.09 Pain Relevance 0.87
Previous studies have shown that neurons in the sacral dorsal commissural nucleus (SDCN) express neurokinin-1 receptor (NK1R) and can be modulated by the co-release of GABA and glycine (Gly) from single presynaptic terminal.
Localization (release) of glycine in neurons associated with gaba
3) Confidence 0.03 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16043285 Disease Relevance 0.06 Pain Relevance 0.13
The ability of gamma-aminobutyric acid (GABA) and glycine (Gly) to modulate each other's release was studied in synaptosomes from rat spinal cord, cerebellum, cerebral cortex, or hippocampus, prelabeled with [3H]GABA or [3H]Gly and exposed in superfusion to Gly or to GABA, respectively.
Localization (release) of glycine in cerebellum associated with gaba, hippocampus, cerebral cortex and spinal cord
4) Confidence 0.01 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1402899 Disease Relevance 0 Pain Relevance 0.50
The ability of gamma-aminobutyric acid (GABA) and glycine (Gly) to modulate each other's release was studied in synaptosomes from rat spinal cord, cerebellum, cerebral cortex, or hippocampus, prelabeled with [3H]GABA or [3H]Gly and exposed in superfusion to Gly or to GABA, respectively.
Localization (release) of glycine in cerebral cortex associated with gaba, hippocampus, cerebral cortex and spinal cord
5) Confidence 0.01 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1402899 Disease Relevance 0 Pain Relevance 0.50

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