INT92119

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Context Info
Confidence 0.14
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.88
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
paw 2
beta cell 2
peripheral nervous system 2
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 11 100.00 Very High Very High Very High
cytokine 7 100.00 Very High Very High Very High
chemokine 3 100.00 Very High Very High Very High
Peripheral nervous system 4 99.84 Very High Very High Very High
Neuritis 9 99.36 Very High Very High Very High
Morphine 7 99.32 Very High Very High Very High
Analgesic 4 98.28 Very High Very High Very High
tail-flick 1 66.72 Quite High
Opioid 1 61.56 Quite High
Sciatic nerve 1 42.40 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 9 99.36 Very High Very High Very High
Pressure And Volume Under Development 2 92.76 High High
Autoimmune Disease 4 87.24 High High
Multiple Sclerosis 2 86.00 High High
Demyelinating Disease 1 81.12 Quite High
Syndrome 1 74.08 Quite High
Immunization 1 55.52 Quite High
Disease 1 44.80 Quite Low
Viral Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the current study has demonstrated the in vivo anti-inflammatory and analgesic effects of PSF, and suggested that the molecular mechanisms might be associated with inhibition of the elevated expression of COX-2 protein and the overproduction of the proinflammatory cytokines, as well as augmentation of the anti-inflammatory cytokines IL-4 and IL-10 in the carrageenan-injected paw tissues of rats.
Negative_regulation (inhibition) of Positive_regulation (augmentation) of cytokines IL-4 in paw associated with inflammation, analgesic and cytokine
1) Confidence 0.14 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18379056 Disease Relevance 0.60 Pain Relevance 0.66
Protective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous system.
Negative_regulation (down-regulation) of Positive_regulation (up-regulation) of IL-4 in peripheral nervous system associated with chemokine, peripheral nervous system, inflammation, experimental autoimmune neuritis and neuritis
2) Confidence 0.14 Published 2000 Journal Autoimmunity Section Title Doc Link 11078155 Disease Relevance 1.28 Pain Relevance 0.89
Morphine administration was also found to inhibit IL-4 induced up-regulation of MHC II RT1.B beta cell surface expression on B lymphocytes.
Negative_regulation (inhibit) of Positive_regulation (up-regulation) of IL-4 in beta cell associated with morphine
3) Confidence 0.11 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14742686 Disease Relevance 0 Pain Relevance 0.65

General Comments

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