INT92129

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Context Info
Confidence 0.08
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 12.13
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) cytoplasm (F3)
Anatomy Link Frequency
Plaque 6
monocyte 4
macrophages 2
endothelial cells 2
vasculature 2
F3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 13 100.00 Very High Very High Very High
Inflammatory mediators 6 100.00 Very High Very High Very High
Potency 31 99.80 Very High Very High Very High
metalloproteinase 1 99.28 Very High Very High Very High
Inflammation 44 93.44 High High
aspirin 6 92.56 High High
Angina 14 90.00 High High
cytokine 20 80.64 Quite High
antagonist 42 72.72 Quite High
agonist 11 64.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 63 100.00 Very High Very High Very High
Adhesions 11 100.00 Very High Very High Very High
Rupture 4 99.98 Very High Very High Very High
Sepsis 48 99.88 Very High Very High Very High
Atherosclerosis 31 99.74 Very High Very High Very High
Stress 19 99.48 Very High Very High Very High
Disease 42 99.00 Very High Very High Very High
Coronary Heart Disease 4 98.92 Very High Very High Very High
Spontaneous Abortion 4 98.88 Very High Very High Very High
Hyperhomocysteinemia 15 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the left hand aromatic ring of the structure, substitution in both the ortho and meta positions with either halogen or CF3 groups was a definite requirement for potency.
Positive_regulation (requirement) of Gene_expression (positions) of CF3 associated with potency
1) Confidence 0.08 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.25
Stx2 and EHEC-LPS induce platelet-monocyte aggregate formation and tissue factor expression under shear stress
Positive_regulation (formation) of Gene_expression (expression) of tissue factor in monocyte associated with stress
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.10 Pain Relevance 0.09
We demonstrated that complement activation induces tissue factor expression on macrophages stimulating sFlt-1 release and causing placental angiogenesis failure and abnormal pregnancies.
Positive_regulation (induces) of Gene_expression (expression) of tissue factor in macrophages
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.88 Pain Relevance 0.13
Setty et al. [19] has reported increased tissue factor expression and thrombin generation induced by free heme.
Positive_regulation (increased) of Gene_expression (expression) of tissue factor
4) Confidence 0.06 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.43 Pain Relevance 0
Setty et al. [19] has reported increased tissue factor expression and thrombin generation induced by free heme.
Positive_regulation (induced) of Gene_expression (expression) of tissue factor
5) Confidence 0.06 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.46 Pain Relevance 0
In atherosclerosis prone animals like apoE-/- mice, hyperhomocysteinemia accelerates the development of atherosclerosis through the enhanced expression of inflammatory mediators (e.g. receptor for advanced glycation end products (RAGE), vascular cell adhesion molecule-1 (VCAM-1), tissue factor (TF), and matrix metalloproteinase-9 (MMP-9) [76]) and by the dysregulation of lipid metabolism [77].
Positive_regulation (enhanced) of Gene_expression (expression) of tissue factor associated with inflammatory mediators, atherosclerosis, metalloproteinase, adhesions and hyperhomocysteinemia
6) Confidence 0.05 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 1.29 Pain Relevance 0.10
In these abortion-prone matings, generation of the anaphylotoxin C5a and increased tissue factor expression, causes dysregulation of angiogenic factors and abnormal placental development [5], [6].
Positive_regulation (increased) of Gene_expression (expression) of tissue factor associated with spontaneous abortion
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.80 Pain Relevance 0.03
When the F3 structure was determined, the ?
Positive_regulation (When) of Gene_expression (structure) of F3
8) Confidence 0.05 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0.18 Pain Relevance 0
Plaque rupture promotes activation of the inflammatory response and increased expression of tissue factor (TF), which in turn acts as one of the major initiators of extrinsic coagulation.
Positive_regulation (increased) of Gene_expression (expression) of tissue factor in Plaque associated with inflammatory response and rupture
9) Confidence 0.02 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861775 Disease Relevance 0.78 Pain Relevance 0.17
Plaque rupture promotes activation of the inflammatory response and increased expression of tissue factor (TF), which in turn acts as one of the major initiators of extrinsic coagulation.
Positive_regulation (activation) of Gene_expression (expression) of tissue factor in Plaque associated with inflammatory response and rupture
10) Confidence 0.02 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861775 Disease Relevance 0.79 Pain Relevance 0.17
Plaque rupture promotes activation of the inflammatory response and increased expression of tissue factor (TF), which in turn acts as one of the major initiators of extrinsic coagulation.
Positive_regulation (promotes) of Gene_expression (expression) of tissue factor in Plaque associated with inflammatory response and rupture
11) Confidence 0.02 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861775 Disease Relevance 0.79 Pain Relevance 0.17
Plasma tissue factor (TF) levels collected into the stenotic coronary artery may be an index of TF expression within the vasculature.
Positive_regulation (index) of Gene_expression (levels) of Plasma tissue factor in vasculature
12) Confidence 0.02 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 11078261 Disease Relevance 0.34 Pain Relevance 0.36
Asymmetric dimethylarginine induces tissue factor expression in monocytes via NF-kappaB-dependent pathway: Role in acute coronary syndromes.
Positive_regulation (induces) of Gene_expression (expression) of tissue factor in monocytes associated with acute coronary syndrome
13) Confidence 0.02 Published 2009 Journal Atherosclerosis Section Title Doc Link 19167713 Disease Relevance 0.85 Pain Relevance 0.43
The oxidants produced in endothelial cells during sepsis also induce expression of tissue factor [30, 60].
Positive_regulation (induce) of Gene_expression (expression) of tissue factor in endothelial cells associated with sepsis
14) Confidence 0.01 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.45 Pain Relevance 0.11

General Comments

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