INT92133

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.70
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) signal transduction (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
Purkinje cells 1
Ednrb (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 28 100.00 Very High Very High Very High
Pain 4 99.82 Very High Very High Very High
agonist 10 99.58 Very High Very High Very High
Inflammation 7 98.96 Very High Very High Very High
Action potential 32 98.12 Very High Very High Very High
antagonist 22 96.48 Very High Very High Very High
substantia gelatinosa 57 93.84 High High
Spinal cord 18 93.76 High High
addiction 1 91.04 High High
GABAergic 17 87.96 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 7 100.00 Very High Very High Very High
INFLAMMATION 9 98.96 Very High Very High Very High
Nociception 9 98.44 Very High Very High Very High
Ganglion Cysts 6 81.36 Quite High
Pain 5 75.00 Quite High
Nervous System Injury 2 66.28 Quite High
Neuropathic Pain 1 65.20 Quite High
Pressure And Volume Under Development 2 60.64 Quite High
Inflammatory Pain 2 45.92 Quite Low
Epilepsy 1 42.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeted disruption of the endothelin-B-receptor gene attenuates inflammatory nociception and cutaneous inflammation in mice.
Negative_regulation (disruption) of endothelin-B associated with nociception, pain and inflammation
1) Confidence 0.42 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 11078342 Disease Relevance 1.00 Pain Relevance 0.40
The selective regulation of TTX-S I(Na) was supported by reductions in transcript and protein levels of TTX-S Na(v)1s, particularly Na(v)1.7.
Negative_regulation (reductions) of TTX-S
2) Confidence 0.09 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16870743 Disease Relevance 0.64 Pain Relevance 0.74
Therefore, the developmental enhancement of the clonidine-mediated inhibition of sIPSCs is attributed to an age-dependent increase in AP-derived sIPSCs, which can be blocked by clonidine.
Negative_regulation (inhibition) of sIPSCs associated with action potential and clonidine
3) Confidence 0.06 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691636 Disease Relevance 0 Pain Relevance 0.69
In parallel with this rise in the rate of firing, the magnitude of the clonidine-mediated inhibition of sIPSCs increased during postnatal development.
Negative_regulation (inhibition) of sIPSCs associated with clonidine
4) Confidence 0.05 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691636 Disease Relevance 0 Pain Relevance 0.78
Here we found that the inhibitory effect of clonidine on sIPSCs was enhanced during postnatal development.
Negative_regulation (effect) of sIPSCs associated with clonidine
5) Confidence 0.04 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691636 Disease Relevance 0 Pain Relevance 0.59
Our previous study demonstrated that the selective alpha2-adrenoceptor agonist clonidine partially depresses spontaneous inhibitory postsynaptic currents (sIPSCs) in mouse cerebellar Purkinje cells (PCs).
Negative_regulation (depresses) of sIPSCs in Purkinje cells associated with agonist and clonidine
6) Confidence 0.04 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691636 Disease Relevance 0 Pain Relevance 0.53
The observation that sEJP fall time (40 ms) was similar to the estimate of the rate of Ca2+ influx, 1/k2 (42 ms) argues that the focal Ca2+ transients and sEJPs within a SMC are determined by a common mechanism – ion conductance through P2X1 receptors.
Spec (determined) Negative_regulation (determined) of sEJPs
7) Confidence 0.01 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.04
Our results showed that LY 293558 could decrease the frequency of both sIPSCs and mIPSCs.
Negative_regulation (decrease) of sIPSCs
8) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.06 Pain Relevance 0.68

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