INT92139

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 15.62
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (MLH1) nucleus (MLH1) cell cycle (MLH1)
Anatomy Link Frequency
colon 2
MLH1 2
germline 1
GALT 1
urothelial cell 1
MLH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 6 99.00 Very High Very High Very High
cINOD 7 93.04 High High
endometriosis 8 81.20 Quite High
Taxol 5 72.08 Quite High
pain pelvic 2 54.24 Quite High
abdominal pain 11 44.00 Quite Low
anesthesia 1 14.92 Low Low
imagery 8 5.00 Very Low Very Low Very Low
COX2 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 204 100.00 Very High Very High Very High
Cancer 492 99.98 Very High Very High Very High
Endometrial Cancer 165 99.98 Very High Very High Very High
Carcinoma 156 99.98 Very High Very High Very High
Endometriosis (extended) 20 99.84 Very High Very High Very High
Adenomatous Polyps 27 99.44 Very High Very High Very High
Dysmenorrhea 6 99.00 Very High Very High Very High
Microsatellite Instability 123 98.98 Very High Very High Very High
Syndrome 221 98.34 Very High Very High Very High
Hereditary Nonpolyposis Colorectal Neoplasms 115 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most clinically significant extracolonic cancer associated with HNPCC is endometrial cancer, for which women have a 60% lifetime risk [11].
HNPCC Binding (associated) of associated with endometriosis (extended) and cancer
1) Confidence 0.42 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 1.07 Pain Relevance 0
Specific histological characteristics have been found for urothelial cell carcinomas associated with HNPCC.
HNPCC Binding (associated) of in urothelial cell associated with carcinoma
2) Confidence 0.42 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 1.22 Pain Relevance 0
Previous studies [49] indicate that there are several ways to verify whether or not a particular tumour may be associated with HNPCC.
HNPCC Binding (associated) of associated with cancer
3) Confidence 0.41 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837058 Disease Relevance 1.71 Pain Relevance 0
The situation is different in certain genetically susceptible subgroups, such as in individuals with genetic mutations associated with hereditary nonpolyposis colon cancer (HNPCC) or familiar adenomatous polyps (FAP) in whom lifetime risk increases up to 70-90% and in whom the benefit of a chemopreventive drug might justify its use even in the presence of adverse effects.
HNPCC Spec (might) Binding (associated) of in colon associated with colon cancer and adenomatous polyps
4) Confidence 0.36 Published 2007 Journal Anticancer Res. Section Abstract Doc Link 17970056 Disease Relevance 0.68 Pain Relevance 0.32
MSI has been detected in 75% of endometrial carcinoma associated with HNPCC [8, 9].
HNPCC Binding (associated) of associated with microsatellite instability and endometrial cancer
5) Confidence 0.36 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.82 Pain Relevance 0
The Muir-Torre syndrome was independently described by Muir in 1967 and Torre in 1968, and has since been recognized as a subtype of Lynch Type II hereditary nonpolyposis colon cancer (HNPCC) [4,5].
HNPCC Binding (recognized) of in colon associated with syndrome and colon cancer
6) Confidence 0.35 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1386670 Disease Relevance 1.70 Pain Relevance 0
Aside from demonstrating an MMR mutation, patients may be clinically diagnosed with HNPCC if their family cancer history meets the Amsterdam Criteria II, which encompasses CRC and associated extracolonic sites [13].
HNPCC Binding (diagnosed) of associated with cancer and colon cancer
7) Confidence 0.32 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 1.14 Pain Relevance 0
Reported MMR mutations have been catalogued in three online databases that document the full spectrum of mutations and phenotypes associated with HNPCC [5-7].
HNPCC Binding (associated) of
8) Confidence 0.31 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 1.34 Pain Relevance 0
MLH1 combines with the protein product of hPMS2 to form the hMutL?
MLH1 Binding (form) of in MLH1
9) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.55 Pain Relevance 0
MLH1 combines with the protein product of hPMS2 to form the hMutL?
MLH1 Binding (combines) of in MLH1
10) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.54 Pain Relevance 0
The MMR genes mutated in the germline in HNPCC have been identified so far as hMSH2 (located on 2p), hMLH1 (located on 3p), hPMS1, hPMS2 and hMSH6.
HNPCC Binding (germline) of in germline
11) Confidence 0.08 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.26 Pain Relevance 0
In addition, hMSH2, hMLH1, p16Ink4 and GALT genes were associated for the first time with adenomyosis and its pathogenesis.
hMLH1 Binding (associated) of in GALT associated with dismenorea
12) Confidence 0.02 Published 2000 Journal Int. J. Mol. Med. Section Abstract Doc Link 11078826 Disease Relevance 0.77 Pain Relevance 0.53
There are no reported cases of endometrioid cancer associated with HNPCC.
HNPCC Neg (no) Binding (associated) of associated with cancer
13) Confidence 0.01 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 1.82 Pain Relevance 0.15

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