INT92142

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Context Info
Confidence 0.46
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.64
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH2) ATPase activity (MSH2) nucleus (MSH2)
enzyme binding (MSH2) DNA binding (MSH2)
Anatomy Link Frequency
germline 1
GALT 1
MSH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 6 99.00 Very High Very High Very High
endometriosis 2 81.48 Quite High
cytokine 4 75.32 Quite High
Inflammation 24 74.52 Quite High
Pain 2 38.72 Quite Low
imagery 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 67 99.44 Very High Very High Very High
Ureteral Neoplasms 12 99.34 Very High Very High Very High
Dysmenorrhea 6 99.00 Very High Very High Very High
Microsatellite Instability 25 95.80 Very High Very High Very High
Cancer 108 95.24 Very High Very High Very High
Urinary Tract Cancer 5 90.60 High High
Colon Cancer 32 86.60 High High
Genomic Instability 9 85.88 High High
Ovarian Cancer 1 84.76 Quite High
Endometriosis (extended) 4 81.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, a British study reported 13 ureteral cancers in 130 HNPCC patients; all were associated with MSH2 mutations [20].
MSH2 Binding (associated) of associated with ureteral neoplasms
1) Confidence 0.46 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 1.06 Pain Relevance 0
The mismatch is detected by two complexes, the hMSH2-GTBP/hMSH6 and the hMSH2-hMSH3 heterodimers after interaction with hMLH1-hPMS2 heterodimers, an endonuclease is activated and incises the newly synthesized DNA strand that contains the mutation 14.
hMSH2 Binding (complexes) of
2) Confidence 0.36 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.81 Pain Relevance 0.11
The mismatch is detected by two complexes, the hMSH2-GTBP/hMSH6 and the hMSH2-hMSH3 heterodimers after interaction with hMLH1-hPMS2 heterodimers, an endonuclease is activated and incises the newly synthesized DNA strand that contains the mutation 14.
hMSH2 Binding (complexes) of
3) Confidence 0.36 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.80 Pain Relevance 0.11
HNPCC patients with endometrial cancers have an inherited germline mutation in MLH-1, MSH-2, MSH-6, or PMS-2, but endometrial cancer only develops after the instauration of a deletion or mutation in the contralateral MLH-1, MSH-2, MSH-6, or PMS-2 allele.
MSH-2 Binding (mutation) of in germline associated with endometrial cancer
4) Confidence 0.22 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 2.21 Pain Relevance 0
In addition, hMSH2, hMLH1, p16Ink4 and GALT genes were associated for the first time with adenomyosis and its pathogenesis.
hMSH2 Binding (associated) of in GALT associated with dismenorea
5) Confidence 0.02 Published 2000 Journal Int. J. Mol. Med. Section Abstract Doc Link 11078826 Disease Relevance 0.77 Pain Relevance 0.53

General Comments

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