INT92151

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 6.31
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
brain 1
intestine 1
Faah (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 16 100.00 Very High Very High Very High
analgesia 13 100.00 Very High Very High Very High
qutenza 4 100.00 Very High Very High Very High
Neuropathic pain 17 99.84 Very High Very High Very High
Inflammation 22 99.40 Very High Very High Very High
Endocannabinoid 55 98.44 Very High Very High Very High
Cannabinoid 29 98.24 Very High Very High Very High
Eae 18 97.00 Very High Very High Very High
cannabis 5 94.40 High High
Potency 3 91.36 High High
Disease Link Frequency Relevance Heat
Sepsis 40 100.00 Very High Very High Very High
Ileus 16 100.00 Very High Very High Very High
Neuropathic Pain 31 99.84 Very High Very High Very High
INFLAMMATION 23 99.40 Very High Very High Very High
Drug Induced Neurotoxicity 2 98.28 Very High Very High Very High
Inflammatory Pain 9 97.00 Very High Very High Very High
Syndrome 2 96.32 Very High Very High Very High
Hyperalgesia 9 93.72 High High
Targeted Disruption 10 87.80 High High
Peripheral Neuropathy 2 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cannabidiol also regulates the activity of fatty acid amide hydrolase (FAAH) which is the main enzyme involved in endocannabinoid breakdown and which modulates gastrointestinal motility.
Regulation (regulates) of fatty acid amide hydrolase associated with endocannabinoid
1) Confidence 0.62 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.99 Pain Relevance 0.30
Cannabidiol also regulates the activity of fatty acid amide hydrolase (FAAH) which is the main enzyme involved in endocannabinoid breakdown and which modulates gastrointestinal motility.
Regulation (regulates) of FAAH associated with endocannabinoid
2) Confidence 0.62 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.99 Pain Relevance 0.30
Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase.
Regulation (Effect) of fatty acid amide hydrolase associated with qutenza and sepsis
3) Confidence 0.45 Published 2008 Journal Neurogastroenterol. Motil. Section Title Doc Link 18373655 Disease Relevance 1.01 Pain Relevance 0.37
The effects of inhibition of FAAH on neuropathic pain behaviour are less consistent than those reported for inflammatory pain states.
Regulation (effects) of FAAH associated with eae and neuropathic pain
4) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 1.37 Pain Relevance 1.08
This investigation tests the hypothesis that fatty acid amide hydrolase (FAAH), a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide), is a sensitive target for OP pesticides with possible secondary neurotoxicity.
Spec (possible) Regulation (target) of fatty acid amide hydrolase associated with drug induced neurotoxicity and analgesia
5) Confidence 0.27 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11350214 Disease Relevance 0.28 Pain Relevance 0.13
This investigation tests the hypothesis that fatty acid amide hydrolase (FAAH), a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide), is a sensitive target for OP pesticides with possible secondary neurotoxicity.
Spec (possible) Regulation (target) of FAAH associated with drug induced neurotoxicity and analgesia
6) Confidence 0.27 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11350214 Disease Relevance 0.28 Pain Relevance 0.13
These data suggest a ligand/receptor relationship between AEA and CB(1) in these two brain regions, where tonic activation of the receptor may tightly regulate the biosynthesis of its endogenous ligand. 2-Arachidonoyl glycerol levels and fatty acid amide hydrolase activity were unchanged in CB(1)-/- with respect to CB(1)+/+ mice in all regions.
Regulation (regulate) of fatty acid amide hydrolase in brain
7) Confidence 0.25 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11080195 Disease Relevance 0.32 Pain Relevance 0.45
Because of the therapeutic potential of cannabidiol in several pathologies, we investigated its effect on sepsis-induced ileus and on cannabinoid receptor and FAAH expression in the mouse intestine.
Spec (investigated) Regulation (effect) of FAAH in intestine associated with ileus, cannabinoid receptor and sepsis
8) Confidence 0.20 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 1.06 Pain Relevance 0.30

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