INT9217

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Context Info
Confidence 0.58
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 1.13
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTR) small molecule metabolic process (MTR) methyltransferase activity (MTR)
intracellular (MTR) cellular nitrogen compound metabolic process (MTR) cytoplasm (MTR)
Anatomy Link Frequency
plasma 3
white blood cells 1
liver 1
fibroblasts 1
B12 1
MTR (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 24 99.72 Very High Very High Very High
withdrawal 3 98.52 Very High Very High Very High
antidepressant 146 82.08 Quite High
depression 114 80.92 Quite High
induced neuropathy 1 75.00 Quite High
methotrexate 2 28.44 Quite Low
sSRI 18 5.00 Very Low Very Low Very Low
noradrenaline 14 5.00 Very Low Very Low Very Low
tricyclic antidepressant 12 5.00 Very Low Very Low Very Low
fluoxetine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Homocystinuria 4 98.36 Very High Very High Very High
Disease 13 96.48 Very High Very High Very High
Toxicity 2 91.84 High High
Neurologic Manifestations 1 90.92 High High
Neuropathic Pain 2 86.40 High High
Macrocytic Anemia 1 84.84 Quite High
Depression 122 80.92 Quite High
Pulmonary Disease 1 77.68 Quite High
Muscle Hypotonia 1 50.80 Quite High
Convulsion 1 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This offers further support for the biochemical hypothesis of methionine synthetase inhibition by nitrous oxide and reproduces in man previously reported animal studies with methionine.
Negative_regulation (inhibition) of methionine synthetase
1) Confidence 0.58 Published 1992 Journal J. Neurol. Section Abstract Doc Link 1403023 Disease Relevance 0.43 Pain Relevance 0.07
RESULTS: After nitrous oxide exposure, a considerable inactivation of methionine synthase in mononuclear white blood cells was seen in all patients, reaching a nadir after 5-48 h.
Negative_regulation (inactivation) of methionine synthase in white blood cells
2) Confidence 0.56 Published 1994 Journal Anesthesiology Section Body Doc Link 8017644 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Our data suggest that short time exposure to nitrous oxide selectively impairs the function of the cobalamin-dependent methionine synthase.
Negative_regulation (impairs) of cobalamin-dependent methionine synthase
3) Confidence 0.41 Published 1994 Journal Anesthesiology Section Body Doc Link 8017644 Disease Relevance 0 Pain Relevance 0
The inactivation of methionine synthase by nitrous oxide in cultured human fibroblasts is decreased at high concentrations of methionine in culture medium.
Negative_regulation (inactivation) of methionine synthase in fibroblasts
4) Confidence 0.41 Published 1994 Journal Anesthesiology Section Abstract Doc Link 8017644 Disease Relevance 0 Pain Relevance 0.07
The inactivation of methionine synthase was associated with a transient increase in plasma homocysteine, and the homocysteine concentration was still increased (mean 28.7%) 7 days after anesthesia in the patients not receiving methionine.
Negative_regulation (inactivation) of methionine synthase in plasma
5) Confidence 0.41 Published 1994 Journal Anesthesiology Section Body Doc Link 8017644 Disease Relevance 0 Pain Relevance 0
In the patients receiving a methionine load, the kinetics of inactivation of methionine synthase were similar, but the rate and extent of enzyme recovery was higher than in patients not receiving methionine, and in four patients, the enzyme activity even exceeded the preoperative level.
Negative_regulation (inactivation) of methionine synthase
6) Confidence 0.41 Published 1994 Journal Anesthesiology Section Body Doc Link 8017644 Disease Relevance 0 Pain Relevance 0
OBJECTIVES: Oxidation of vitamin B12 by nitrous oxide leads to the inactivation of methionine synthase resulting in elevated plasma total homocysteine concentrations.
Negative_regulation (inactivation) of methionine synthase in plasma
7) Confidence 0.38 Published 2009 Journal Pharmacogenet. Genomics Section Abstract Doc Link 19339913 Disease Relevance 0 Pain Relevance 0.14
The average increase in plasma homocysteine was 2.4 mumol/l (+28%) in all three groups indicating the expected inactivation of methionine synthase by nitrous oxide through oxidation of vitamin B12, but no genetic effect.
Negative_regulation (inactivation) of methionine synthase in plasma
8) Confidence 0.38 Published 2009 Journal Pharmacogenet. Genomics Section Body Doc Link 19339913 Disease Relevance 0 Pain Relevance 0
The decrease in MTR during general anesthesia is probably due to mechanisms other than alterations in the physical properties of mucus.
Negative_regulation (decrease) of MTR associated with anesthesia
9) Confidence 0.38 Published 1990 Journal Chest Section Abstract Doc Link 2361374 Disease Relevance 0.08 Pain Relevance 0.30
These results in humans are similar to those in animals and suggest that inactivation of methionine synthetase may play a role in the development of the pathologic effects seen in patients and medical personnel after exposure to nitrous oxide.
Negative_regulation (inactivation) of methionine synthetase
10) Confidence 0.38 Published 1982 Journal Anesth. Analg. Section Abstract Doc Link 7198880 Disease Relevance 0 Pain Relevance 0
Nitrous oxide inactivates methionine synthetase in human liver.
Negative_regulation (inactivates) of methionine synthetase in liver associated with anesthesia
11) Confidence 0.38 Published 1982 Journal Anesth. Analg. Section Title Doc Link 7198880 Disease Relevance 0 Pain Relevance 0.10
Inactivation of methionine synthetase progressively increased as the product of the concentration of nitrous oxide and the exposure time increased.
Negative_regulation (Inactivation) of methionine synthetase
12) Confidence 0.38 Published 1982 Journal Anesth. Analg. Section Abstract Doc Link 7198880 Disease Relevance 0 Pain Relevance 0
Inactivation of methionine synthase is very much more rapid in the rat exposed to 50% nitrous oxide, with a half-time of 5.4 min.
Negative_regulation (Inactivation) of methionine synthase
13) Confidence 0.19 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3341574 Disease Relevance 0 Pain Relevance 0.19
The rate of inactivation of hepatic methionine synthase by nitrous oxide has been determined in 22 patients undergoing laparotomy during general anesthesia, including 70% nitrous oxide.
Negative_regulation (inactivation) of methionine synthase associated with anesthesia
14) Confidence 0.17 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3341574 Disease Relevance 0 Pain Relevance 0.18
With this in mind, the following 7 (out of the possible 27) genes in the folate pathway will be investigated in the first instance:

• methylenetetrahydrofolate reductase • thymidylate synthase • dihydrofolate reductase • methionine synthase • methionine synthase reductase • gamma glutamyl hydrolase • reduced folate carrier (SLC19A1).

Negative_regulation (reductase) of methionine synthase
15) Confidence 0.07 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2238748 Disease Relevance 0.08 Pain Relevance 0.08
With this in mind, the following 7 (out of the possible 27) genes in the folate pathway will be investigated in the first instance:

• methylenetetrahydrofolate reductase • thymidylate synthase • dihydrofolate reductase • methionine synthase • methionine synthase reductase • gamma glutamyl hydrolase • reduced folate carrier (SLC19A1).

Negative_regulation (reductase) of methionine synthase
16) Confidence 0.07 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2238748 Disease Relevance 0.08 Pain Relevance 0.08
The consequent functional deficiencies of methylmalonyl-CoA mutase and methionine synthase produce both methylmalonic aciduria and homocystinuria.
Negative_regulation (deficiencies) of methionine synthase associated with homocystinuria
17) Confidence 0.07 Published 1997 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 9266389 Disease Relevance 0.22 Pain Relevance 0.05
Nitrous oxide depresses the two known vitamin B12 dependent enzymes methylmalonyl CoA mutase and methionine synthetase by inactivation of their coenzymes adenosylcobalamin and methylcobalamin respectively.
Negative_regulation (depresses) of methionine synthetase in B12
18) Confidence 0.06 Published 1982 Journal Can Anaesth Soc J Section Abstract Doc Link 7074405 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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