INT92182

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Context Info
Confidence 0.07
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.29
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adk) nucleus (Adk) kinase activity (Adk)
Anatomy Link Frequency
brain 1
Mir702 (Mus musculus)
Adk (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 39 98.68 Very High Very High Very High
Neurotransmitter 6 96.96 Very High Very High Very High
Inflammation 6 81.12 Quite High
Analgesic 6 80.24 Quite High
Antinociceptive 6 75.00 Quite High
antagonist 15 64.48 Quite High
Opioid 3 40.40 Quite Low
narcan 3 38.96 Quite Low
cINOD 3 25.12 Quite Low
Disease Link Frequency Relevance Heat
Nociception 12 89.52 High High
INFLAMMATION 9 81.12 Quite High
Injury 3 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AK inhibition by ABT-702 was demonstrated to be reversible after 4 h of dialysis.
ABT-702 Negative_regulation (inhibition) of AK
1) Confidence 0.07 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11082453 Disease Relevance 0.43 Pain Relevance 0.86
Kinetic studies revealed that AK inhibition by ABT-702 was competitive with respect to ADO and noncompetitive with respect to MgATP(2-).
ABT-702 Negative_regulation (inhibition) of AK associated with adenocard
2) Confidence 0.07 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11082453 Disease Relevance 0.43 Pain Relevance 0.82
ABT-702 was equipotent (IC(50) = 1.5 +/- 0. 3 nM) in inhibiting native human AK (placenta), two human recombinant isoforms (AK(long) and AK(short)), and AK from monkey, dog, rat, and mouse brain.
ABT-702 Negative_regulation (inhibiting) of AK in brain
3) Confidence 0.07 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11082453 Disease Relevance 0.43 Pain Relevance 0.78

General Comments

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