INT92195

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.92
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn3) extracellular region (Edn3)
Anatomy Link Frequency
juvenile 1
enteric nervous system 1
body 1
Edn3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 98.22 Very High Very High Very High
Inflammation 1 97.60 Very High Very High Very High
Visceral pain 1 96.92 Very High Very High Very High
Opioid 1 95.40 Very High Very High Very High
bradykinin 1 94.92 High High
substance P 1 94.08 High High
Disease Link Frequency Relevance Heat
Central Hypoventilation Syndrome 6 99.48 Very High Very High Very High
INFLAMMATION 1 97.60 Very High Very High Very High
Disease 7 97.12 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 96.92 Very High Very High Very High
Hirschsprung Disease 3 95.48 Very High Very High Very High
Hypoxia 4 90.96 High High
Targeted Disruption 3 78.20 Quite High
Hypercapnia 2 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the possible involvement of ET-3 in central ventilatory control, we measured ventilation in mutant mice deficient in ET-3 by whole body plethysmography.
Negative_regulation (deficient) of ET-3 in body
1) Confidence 0.43 Published 2001 Journal Respir Physiol Section Abstract Doc Link 11084198 Disease Relevance 0.72 Pain Relevance 0
Normal ventilation and ventilatory responses to chemical stimuli in juvenile mutant mice deficient in endothelin-3.
Negative_regulation (deficient) of endothelin-3 in juvenile associated with anesthesia
2) Confidence 0.43 Published 2001 Journal Respir Physiol Section Title Doc Link 11084198 Disease Relevance 0.74 Pain Relevance 0.10
Other peptides may have developmental roles: for example, disruption of endothelin-3 signalling prevents the normal development of the enteric nervous system and contributes to the pathogenesis of Hirschsprung disease.
Negative_regulation (disruption) of endothelin-3 in enteric nervous system associated with hirschsprung disease
3) Confidence 0.07 Published 2004 Journal Best Pract. Res. Clin. Endocrinol. Metab. Section Abstract Doc Link 15533770 Disease Relevance 0.36 Pain Relevance 0.34

General Comments

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