INT92199

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 10.11
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
synovial fluid 4
plasma 2
cartilage 2
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 89 100.00 Very High Very High Very High
Clonidine 4 99.36 Very High Very High Very High
noradrenaline 10 99.26 Very High Very High Very High
Inflammation 310 98.88 Very High Very High Very High
cytokine 164 98.44 Very High Very High Very High
rheumatoid arthritis 69 95.84 Very High Very High Very High
Pain 20 95.52 Very High Very High Very High
Central nervous system 4 91.60 High High
Inflammatory response 24 89.52 High High
Osteoarthritis 227 87.76 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 113 100.00 Very High Very High Very High
Injury 146 99.56 Very High Very High Very High
INFLAMMATION 336 98.88 Very High Very High Very High
Fever 7 97.68 Very High Very High Very High
Arthralgia 11 96.00 Very High Very High Very High
Stomach Cancer 4 95.80 Very High Very High Very High
Acute Coronary Syndrome 126 93.96 High High
Sprains And Strains 90 93.92 High High
Disease 104 93.76 High High
Severe Combined Immunodeficiency 6 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the in vitro observation that VNTR allele 2 has been associated with a decreased production of IL-1ra [14,58]; and increased production of IL-1?
Negative_regulation (decreased) of Gene_expression (production) of IL-1ra
1) Confidence 0.58 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.43 Pain Relevance 0.12
The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.
Negative_regulation (suppressed) of Gene_expression (production) of IL-1RA associated with noradrenaline and clonidine
2) Confidence 0.50 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084220 Disease Relevance 0.14 Pain Relevance 0.62
The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.
Negative_regulation (suppressed) of Gene_expression (production) of IL-1RA associated with noradrenaline and clonidine
3) Confidence 0.50 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084220 Disease Relevance 0.13 Pain Relevance 0.60
is IL-1ra, a naturally occurring inhibitor of IL-1?
Negative_regulation (inhibitor) of Gene_expression (is) of IL-1ra
4) Confidence 0.42 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.66 Pain Relevance 0.37
The intron 2, VNTR polymorphism that we have previously described as associated with reduced endothelial cell production of IL-1ra [17] (i.e. endothelial pro-inflammatory) was associated with significant increases in soluble markers of endothelial activation at the time of NSTEMI ACS, including the rise in plasma vWF, a marker known to be associated with clinical outcome [18].
Negative_regulation (reduced) of Gene_expression (production) of IL-1ra in plasma associated with acute coronary syndrome and inflammation
5) Confidence 0.36 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 1.60 Pain Relevance 0.14
A single, daily, subcutaneous 100 mg injection of IL-1ra is the standard dose of IL-1ra for all individuals with normal renal function.
Negative_regulation (injection) of Gene_expression (dose) of IL-1ra
6) Confidence 0.36 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.76 Pain Relevance 0.45
A single, daily, subcutaneous 100 mg injection of IL-1ra is the standard dose of IL-1ra for all individuals with normal renal function.
Negative_regulation (injection) of Gene_expression (dose) of IL-1ra
7) Confidence 0.36 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.76 Pain Relevance 0.45
Also, opposite to findings by Smith et al.[29], we did not find LD between SNPs in IL1R1 and the locus containing IL1A, IL1B, and IL1RN in our study material (r2 ?
Negative_regulation (locus) of Gene_expression (containing) of IL1RN
8) Confidence 0.34 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2859817 Disease Relevance 0.57 Pain Relevance 0.24
Indeed, a continuous and prolonged (8 weeks) production of IL-1ra was detected at the level of the vaginal mucosa of mice following topical delivery of a single inoculum of IL-1ra-secreting S. gordonii.
Negative_regulation (detected) of Gene_expression (production) of IL-1ra
9) Confidence 0.30 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.05 Pain Relevance 0.03
Serial dilutions of either S. gordonii GP1300 culture supernatant (containing 0.1 mg/litre of RVFP/IL-1ra) or purified E. coli RVFP/IL-1ra were tested for their capacity to inhibit IL-1?
Negative_regulation (litre) of Gene_expression (/) of IL-1ra
10) Confidence 0.30 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.06 Pain Relevance 0
Determination of IL-1ra production by recombinant S. gordonii
Negative_regulation (Determination) of Gene_expression (production) of IL-1ra
11) Confidence 0.30 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.36 Pain Relevance 0
Whereas under BIA, the concentrations of IL-6 were found to be significantly elevated during the course of the study, the release of the soluble IL-2R alpha and the production of IL-1RA were reduced in this patient group in comparison to the TIVA group.
Negative_regulation (reduced) of Gene_expression (production) of IL-1RA
12) Confidence 0.13 Published 2001 Journal Anaesthesiol Reanim Section Abstract Doc Link 11256129 Disease Relevance 0.61 Pain Relevance 0.53
Furthermore, synovial fluid levels of the IL-1 receptor antagonist (IL-1Ra) decrease after ACL injury [39].
Negative_regulation (decrease) of Gene_expression (levels) of IL-1Ra in synovial fluid associated with antagonist and injury
13) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 1.32 Pain Relevance 0.37
Furthermore, synovial fluid levels of the IL-1 receptor antagonist (IL-1Ra) decrease after ACL injury [39].
Negative_regulation (decrease) of Gene_expression (levels) of IL-1 receptor antagonist in synovial fluid associated with antagonist and injury
14) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 1.32 Pain Relevance 0.37
Interestingly, overexpression of the IL-1Ra in RA-SFs, did not reduce significantly the invasiveness of these cells into the cartilage.
Neg (not) Negative_regulation (reduce) of Gene_expression (overexpression) of IL-1Ra in cartilage associated with rheumatoid arthritis
15) Confidence 0.06 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 1.34 Pain Relevance 0.44

General Comments

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