INT922

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Context Info
Confidence 0.60
First Reported 1979
Last Reported 1997
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.57
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
plasma 4
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 16 100.00 Very High Very High Very High
fluoxetine 14 100.00 Very High Very High Very High
tricyclic antidepressant 8 100.00 Very High Very High Very High
Endogenous opioid 2 99.84 Very High Very High Very High
Pain 7 98.08 Very High Very High Very High
depression 8 97.88 Very High Very High Very High
antidepressant 3 97.48 Very High Very High Very High
opiate 4 97.32 Very High Very High Very High
antagonist 2 97.04 Very High Very High Very High
Opioid 2 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 5 98.08 Very High Very High Very High
Depression 8 97.88 Very High Very High Very High
Anxiety Disorder 15 97.32 Very High Very High Very High
Stress 5 96.08 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 95.64 Very High Very High Very High
Aggression 1 92.96 High High
Endometriosis (extended) 3 89.76 High High
Nociception 1 87.84 High High
Drug Induced Neurotoxicity 2 83.84 Quite High
Hypoglycemia 1 74.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of naloxone on psychotropic drug-induced prolactin, growth hormone and cortisol secretion--a preliminary report.
Regulation (effect) of Positive_regulation (induced) of prolactin associated with narcan
1) Confidence 0.60 Published 1980 Journal Postgrad Med J Section Title Doc Link 7393831 Disease Relevance 0 Pain Relevance 0.32
The effects of chronic treatment with fluoxetine or tricyclic antidepressants on the L-5-hydroxytryptophan (200 mg, L-5-HTP; PO)-induced increases in plasma cortisol and prolactin (PRL) concentrations were studied in patients with major depression or obsessive compulsive disorder (OCD).
Regulation (effects) of Positive_regulation (increases) of prolactin in plasma associated with depression, anxiety disorder, tricyclic antidepressant and fluoxetine
2) Confidence 0.45 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9194044 Disease Relevance 0.71 Pain Relevance 0.79
The effects of chronic treatment with fluoxetine or tricyclic antidepressants on the L-5-hydroxytryptophan (200 mg, L-5-HTP; PO)-induced increases in plasma cortisol and prolactin (PRL) concentrations were studied in patients with major depression or obsessive compulsive disorder (OCD).
Regulation (effects) of Positive_regulation (increases) of PRL in plasma associated with depression, anxiety disorder, tricyclic antidepressant and fluoxetine
3) Confidence 0.45 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9194044 Disease Relevance 0.71 Pain Relevance 0.79
Cimetidine had no effect on the GH, PRL, or cortisol response to insulin-induced hypolycemia or the 24-h secretion of LH, FSH, testosterone, or PRL.
Neg (no) Regulation (effect) of Positive_regulation (response) of PRL
4) Confidence 0.42 Published 1979 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 113425 Disease Relevance 0.38 Pain Relevance 0.13
In conclusion, the PRL response to TRH may be unaffected by endogenous opioids or naloxone and we were unable to reveal a possible opioid effect in our experimental conditions.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (response) of PRL associated with narcan, endogenous opioid and opioid
5) Confidence 0.41 Published 1989 Journal Minerva Endocrinol. Section Abstract Doc Link 2503692 Disease Relevance 0 Pain Relevance 0.51
Although they resembled controls in their prolactin response to L-tryptophan and their response to ischemic pain, MDMA users had lower scores on personality measures of impulsivity (p = .004) and indirect hostility (p = .009).
Regulation (controls) of Positive_regulation (response) of prolactin associated with pain and attention deficit hyperactivity disorder
6) Confidence 0.40 Published 1994 Journal Neuropsychopharmacology Section Abstract Doc Link 7517677 Disease Relevance 0.71 Pain Relevance 0.30
Differential responses in prolactin levels induced by naloxone in humans.
Regulation (responses) of Positive_regulation (induced) of prolactin associated with narcan
7) Confidence 0.27 Published 1985 Journal Psychoneuroendocrinology Section Title Doc Link 4034850 Disease Relevance 0.24 Pain Relevance 0.58
Its rise in the postpartum stage might be as one of the psychoneuroendocrine mechanisms maintaining elevated prolactin levels during lactation.
Regulation (maintaining) of Positive_regulation (elevated) of prolactin
8) Confidence 0.22 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 2997823 Disease Relevance 0.83 Pain Relevance 0.53

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