INT9220

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Context Info
Confidence 0.77
First Reported 1990
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 125
Total Number 127
Disease Relevance 85.74
Pain Relevance 15.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighg1)
Anatomy Link Frequency
connective tissue 5
goblet cell 2
Th2 cells 2
lung 2
salivary glands 2
Ighg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 14 99.92 Very High Very High Very High
Adalimumab 16 99.90 Very High Very High Very High
Infliximab 73 99.76 Very High Very High Very High
Kappa opioid receptor 8 99.76 Very High Very High Very High
cytokine 947 99.60 Very High Very High Very High
Inflammation 1107 99.48 Very High Very High Very High
Arthritis 488 99.26 Very High Very High Very High
rheumatoid arthritis 449 99.26 Very High Very High Very High
chemokine 111 99.04 Very High Very High Very High
Etanercept 84 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 1297 100.00 Very High Very High Very High
Neuromyelitis Optica 430 100.00 Very High Very High Very High
Aspergillus Infection 133 100.00 Very High Very High Very High
Disease 2604 99.96 Very High Very High Very High
Infection 584 99.96 Very High Very High Very High
Pulmonary Eosinophilia 3 99.92 Very High Very High Very High
Targeted Disruption 242 99.88 Very High Very High Very High
Polymyositis 12 99.62 Very High Very High Very High
Disorders Of The Lacrimal System 357 99.60 Very High Very High Very High
Influenza Virus Infection 340 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, our data showed that neonatal capsaicin treatment did not interfere with either IgG1 or IgE production.
Gene_expression (production) of IgG1
1) Confidence 0.77 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11549890 Disease Relevance 0 Pain Relevance 0
However, in the previous study, while the TNP-specific IgG1 injected into pregnant mice was present in the serum of breastfed FcRn+/- neonates (10-20 ?
Gene_expression (present) of IgG1
2) Confidence 0.71 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.32 Pain Relevance 0
Levels of OVA-specific IgG1 absorbed from breast milk of allergic mothers
Gene_expression (Levels) of IgG1 associated with hypersensitivity
3) Confidence 0.71 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.56 Pain Relevance 0
Similarly, during acute disease following 7 days of OVA aerosol challenge, comparable levels of OVA-specific IgG1 and IgE were present in the serum from B6AAD and FcRn-/-AAD mice (Figure 1B and 1C).
Gene_expression (levels) of IgG1 associated with acute disease and disease
4) Confidence 0.71 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.72 Pain Relevance 0
Administration of indomethacin resulted in suppression of antigen (OVA)-induced arthritis that was associated with inhibition of anti-OVA IgG2a but not IgG1 production.
Gene_expression (production) of IgG1 associated with arthritis
5) Confidence 0.69 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.38
IgG1 production was unaffected by MENK.
Gene_expression (production) of IgG1 associated with enkephalin
6) Confidence 0.68 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.45
Administrations of all the drugs used resulted in suppression of antigen (OVA)-induced arthritis in mice which was associated with inhibition of anti-OVA IgG2a but not IgG1 production.
Gene_expression (production) of IgG1 associated with arthritis
7) Confidence 0.65 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.56 Pain Relevance 0.56
Treatments with IND, DEX, MTX and AUR inhibited both Th1 and Th2 immune responses, although the inhibitory effects of these drugs on the antigen-specific IgG2a and IFN-gamma production appeared to be greater than those on IgG1 and IL-10 production.
Gene_expression (production) of IgG1 associated with methotrexate and dexamethasone
8) Confidence 0.65 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.56 Pain Relevance 0.57
D-PA failed to influence anti-OVA IgG, IgG2a and IgG1 production as well as IFN-gamma and IL-10 secretion.
Gene_expression (production) of IgG1
9) Confidence 0.65 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.57 Pain Relevance 0.57
Compared to wild-type (WT) mice, KOR-/- animals produced significant higher levels of antigen-specific total Ig, IgM, IgG1 and IgG2a antibodies.
Gene_expression (produced) of IgG1 associated with kappa opioid receptor
10) Confidence 0.65 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12507774 Disease Relevance 0.24 Pain Relevance 0.57
C57BL/6 mice developed significant systemic IgE and IgG1 levels following allergenic sensitization and challenge with Af, comparable to the responses of Balb/c mice
Gene_expression (levels) of IgG1 associated with aspergillus infection
11) Confidence 0.63 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.82 Pain Relevance 0.04
A single hybridoma clone was identified that secretes an IgG1,k monoclonal antibody (MAb), designated T20G10, against tetrodotoxin (TTX), with an estimated affinity of 1.2 x 10(8) L/M.
Gene_expression (secretes) of IgG1 associated with tetrodotoxin
12) Confidence 0.62 Published 1992 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 1403332 Disease Relevance 0 Pain Relevance 0.53
Based on these and other data presented in this report, we were able to show that expression of FcRn was important for offspring to acquire sufficient levels of allergen-specific IgG1 from the breast milk of allergic mothers to prevent allergen-specific IgE responses.
Gene_expression (responses) of IgG1 associated with hypersensitivity
13) Confidence 0.62 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.80 Pain Relevance 0
Interestingly, in some experiments performed in this and our other related studies evaluating how allergic mothers influence parameters of allergic disease in offspring, allergen-specific IgG1 and IgE responses were virtually absent without profound effects on airway eosinophilia.
Neg (absent) Gene_expression (responses) of IgG1 associated with hypersensitivity, disease and eosinophilia
14) Confidence 0.62 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 1.10 Pain Relevance 0
We demonstrated that levels of OVA-specific IgG1 absorbed from the gut into the circulation of breastfed offspring was determined by offspring FcRn expression.
Gene_expression (expression) of IgG1 in gut
15) Confidence 0.62 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 1.06 Pain Relevance 0
In the present study, although maternal allergen-specific IgG1, IgA and IgE were present at weaning in naïve FcRn-sufficient mice foster nursed by allergic mothers, it appeared that allergen-specific IgG1 was the only isotype whose levels were sustained until allergic sensitization.
Gene_expression (present) of IgG1 associated with hypersensitivity
16) Confidence 0.62 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 1.09 Pain Relevance 0
Higher levels of both recall serum IgG1 and IgG2a antibodies were also observed in the group immunized by microneedle delivery with trehalose-formulated vaccine (MN+T) than those in the corresponding inramuscular immunization groups (p<0.05 between MN+T and IM+T for both IgG1 and IgG2a) (Fig. 7B and Table 2).
Gene_expression (antibodies) of IgG1 associated with immunization
17) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.92 Pain Relevance 0.03
Higher levels of both recall serum IgG1 and IgG2a antibodies were also observed in the group immunized by microneedle delivery with trehalose-formulated vaccine (MN+T) than those in the corresponding inramuscular immunization groups (p<0.05 between MN+T and IM+T for both IgG1 and IgG2a) (Fig. 7B and Table 2).
Gene_expression (levels) of IgG1 associated with immunization
18) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.92 Pain Relevance 0.03
Antibody concentrations (ng per g lung tissues or ng per ml sera) were determined using standard curves for mouse IgG1 and IgG2a antibodies.
Gene_expression (antibodies) of IgG1 in lung
19) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.51 Pain Relevance 0.09
Upon OVA allergen challenge, sensitized WT mice displayed robust allergic inflammatory responses, including macrophage and eosinophil dominated cell infiltration in the airway and in the lung parenchyma, goblet cell hyperplasia, OVA-specific IgE and IgG1 production, and Th2 cytokine production in the lung.
Gene_expression (production) of IgG1 in lung associated with inflammatory response, hypersensitivity, hyperplasia and cytokine
20) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.68 Pain Relevance 0.23

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