INT92200

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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.66
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
macrophages 2
peritoneal macrophages 2
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 156 100.00 Very High Very High Very High
Inflammation 147 100.00 Very High Very High Very High
fluoxetine 10 99.98 Very High Very High Very High
narcan 2 99.92 Very High Very High Very High
Inflammatory mediators 2 99.68 Very High Very High Very High
antagonist 2 99.56 Very High Very High Very High
opioid receptor 1 99.12 Very High Very High Very High
Analgesic 4 95.12 Very High Very High Very High
Pain 3 92.80 High High
sSRI 8 82.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 156 100.00 Very High Very High Very High
Asthma 48 99.90 Very High Very High Very High
Targeted Disruption 9 99.76 Very High Very High Very High
Cancer 3 99.64 Very High Very High Very High
Hypersensitivity 13 99.56 Very High Very High Very High
Necrosis 2 99.40 Very High Very High Very High
Adhesions 3 94.80 High High
Apoptosis 77 93.44 High High
Pain 3 92.80 High High
Immunization 11 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluoxetine administration for 1 and 2 weeks, but not 4 weeks, stimulates the proliferative activity of splenocytes, whereas a 4-week administration of fluoxetine suppresses the secretion of IL-4.
Negative_regulation (suppresses) of Localization (secretion) of IL-4 associated with fluoxetine
1) Confidence 0.51 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084221 Disease Relevance 0.18 Pain Relevance 0.85
expression was maintained on CD3+ T cells, CD19+ B cells (Figure 1D), and macrophages (unpublished data) in smooth muscle cell–specific IL-4R?
Negative_regulation (maintained) of Localization (specific) of IL-4 in macrophages
2) Confidence 0.41 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.43 Pain Relevance 0
IL-4, -10, or -13 significantly inhibited the release of both tumor necrosis factor (TNF)-alpha (60, 53, and 100%, respectively) and IL-1beta (80, 100, and 100%, respectively) by mice peritoneal macrophages obtained after local (i.p.) injection of zymosan.
Negative_regulation (inhibited) of Localization (release) of IL-4 in peritoneal macrophages associated with necrosis and cancer
3) Confidence 0.40 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490580 Disease Relevance 0.37 Pain Relevance 0.79
Citalopram administered for 1, 2 and 4 weeks stimulates the proliferative activity of splenocytes and suppresses their ability to secrete the anti-inflammatory cytokine IL-4.
Negative_regulation (suppresses) of Localization (secrete) of cytokine IL-4 associated with inflammation and cytokine
4) Confidence 0.33 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084221 Disease Relevance 0.17 Pain Relevance 0.82
(Fig. 6, panels A and B), but significantly reduced both IL-10 and IL-4 release (Fig. 6, panels C and D).
Negative_regulation (reduced) of Localization (release) of IL-4
5) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.16 Pain Relevance 0.07
Splenocytes were obtained and cultured in vitro with H. pylori sonicate to evaluate induction of interferon gamma (IFN-gamma) and interleukin 4 (IL-4) secretion.
Negative_regulation (evaluate) of Localization (secretion) of interleukin 4
6) Confidence 0.30 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12810355 Disease Relevance 0.65 Pain Relevance 0.16
Splenocytes were obtained and cultured in vitro with H. pylori sonicate to evaluate induction of interferon gamma (IFN-gamma) and interleukin 4 (IL-4) secretion.
Negative_regulation (evaluate) of Localization (secretion) of IL-4
7) Confidence 0.30 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12810355 Disease Relevance 0.65 Pain Relevance 0.16
allergic bronchial asthma via suppressing IL-4 secretion, and in consequence,
Negative_regulation (suppressing) of Localization (secretion) of IL-4 associated with asthma and hypersensitivity
8) Confidence 0.21 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.67 Pain Relevance 0.07
After 3.5 h of ovalbumin peptide challenge in culture, the levels of IL-4 secreted by Cerk-/- cells was reduced by 30% (p = 0.04) compared to WT cells (Fig. 2).


Negative_regulation (reduced) of Localization (secreted) of IL-4
9) Confidence 0.20 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.51 Pain Relevance 0.22
1, IL-10 & IL-4 and suppressed release of pro-inflammatory mediators including TNF-?
Negative_regulation (suppressed) of Localization (release) of IL-4 associated with inflammatory mediators
10) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832020 Disease Relevance 1.88 Pain Relevance 0.52

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