INT9223

Context Info Confidence 0.78 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 22 Total Number 23 Disease Relevance 11.03 Pain Relevance 3.67

extracellular space (Ighg1)

Anatomy Link Frequency plasma cells 2 memory B cells 2 plasma 1 radial 1 DCs 1 Ighg1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 125 99.98 alcohol 2 98.74 tetrodotoxin 6 97.72 Opioid 2 96.96 Arthritis 255 92.88 Inflammation 129 92.68 Kappa opioid receptor 3 90.44 methotrexate 16 89.24 dexamethasone 10 89.04 Morphine 6 87.04

Disease Link Frequency Relevance Heat Hypersensitivity 246 100.00 Eosinophilia 11 99.70 Disease 537 99.42 Paratuberculosis 20 98.62 Asthma 166 98.18 Targeted Disruption 23 98.16 Immunization 57 97.96 Pressure And Volume Under Development 60 97.12 Malaria 219 95.36 Sprains And Strains 22 94.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The hybrid-hybridoma generated from this fusion expresses and secretes rat Igs of the IgG1 and IgG2a subclasses, as determined by radial immunodiffusion.

Localization (secretes) of IgG1 in radial

1) Confidence 0.78 Published 1990 Journal Histochemistry Section Abstract Doc Link 2127927 Disease Relevance 0 Pain Relevance 0

Fc sialyation of IgG1 results in a reduced binding affinity for the activating receptor Fc?

Localization (sialyation) of IgG1

2) Confidence 0.69 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.98 Pain Relevance 0.05

Maternal allergen-specific IgG1 prevented allergic sensitization

Localization (sensitization) of IgG1 associated with hypersensitivity

3) Confidence 0.69 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.61 Pain Relevance 0

A single hybridoma clone was identified that secretes an IgG1,k monoclonal antibody (MAb), designated T20G10, against tetrodotoxin (TTX), with an estimated affinity of 1.2 x 10(8) L/M.

Localization (secretes) of IgG1 associated with tetrodotoxin

4) Confidence 0.65 Published 1992 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 1403332 Disease Relevance 0 Pain Relevance 0.53

In late disease (6 to 8 weeks after onset), titres of both IgG1 and IgG2a/c had increased modestly in DBA/1 mice.

Localization (titres) of IgG1 associated with disease

5) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 1.59 Pain Relevance 0.32

Anticollagen IgG2a (regarded as a marker for a Th1 response) was reduced, and there was an increase in IgG1 (regarded as a marker for a Th2 response).

Localization (response) of IgG1

6) Confidence 0.44 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.62 Pain Relevance 0.12

secretion from CD4+ T cells and significant titers of IgG1 and IgG2a WT-1-specific antibodies in HLA-A2 transgenic mouse models.

Localization (secretion) of IgG1 in T cells associated with targeted disruption

7) Confidence 0.40 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.49 Pain Relevance 0.04

Exposure of mice to benzyl alcohol, a metabolite of BBzP, also caused a significant reduction in IgG1 release compared with that in control mice given ovalbumin only (Larsen et al. 2003).

Localization (release) of IgG1 associated with alcohol

8) Confidence 0.40 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453150 Disease Relevance 0 Pain Relevance 0.15

g/ml of heat-killed and paraformaldehyde-fixed M. avium paratuberculosis in coating buffer (sodium carbonate-bicarbonate buffer) or serially diluted human IgG1, IgG2, IgG3, and IgG4 isotype controls overnight at 4°C and blocked with 200 ?

Localization (diluted) of IgG1 associated with paratuberculosis

9) Confidence 0.40 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.15 Pain Relevance 0.03

Steroid therapy is usually effective for improving pancreatic swelling and pancreatic endocrine and exocrine secretion.38,39 These characteristics are similar to those of MD, i.e., elevated concentrations of serum IgG4, infiltration of IgG4-bearing plasma cells into the glands, and recovery of secretion by glucocorticoid treatment.

Localization (infiltration) of IgG4 in plasma cells associated with pressure and volume under development and disease

10) Confidence 0.35 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2785894 Disease Relevance 1.63 Pain Relevance 0.12

Steroid therapy is usually effective for improving pancreatic swelling and pancreatic endocrine and exocrine secretion.38,39 These characteristics are similar to those of MD, i.e., elevated concentrations of serum IgG4, infiltration of IgG4-bearing plasma cells into the glands, and recovery of secretion by glucocorticoid treatment.

Localization (infiltration) of IgG4 in plasma cells associated with pressure and volume under development and disease

11) Confidence 0.35 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2785894 Disease Relevance 1.64 Pain Relevance 0.12

Moreover, these mice also failed to develop IgG1+ memory B cells and autoantigen-specific IgG1 antibodies secreting cells [35].

Localization (secreting) of IgG1 in memory B cells

12) Confidence 0.34 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.73 Pain Relevance 0.32

first screened by ELISA against TREM-1::IgG1 and human IgG (Sigma-Aldrich,

Localization (screened) of IgG1

13) Confidence 0.31 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.09 Pain Relevance 0

Moreover, these mice also failed to develop IgG1+ memory B cells and autoantigen-specific IgG1 antibodies secreting cells [35].

Localization (secreting) of IgG1 in memory B cells

14) Confidence 0.30 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.67 Pain Relevance 0.29

D-PA failed to influence anti-OVA IgG, IgG2a and IgG1 production as well as IFN-gamma and IL-10 secretion.

Localization (secretion) of IgG1

15) Confidence 0.26 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.59 Pain Relevance 0.58

For determination of IgG subclasses (IgG1, IgG2, IgG3 and IgG4), plasma samples diluted 1:50 were added in duplicate and incubated for one hour at room temperature.

Localization (determination) of IgG1 in plasma

16) Confidence 0.24 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.05 Pain Relevance 0

The monoclonal IgG subclasses were diluted 1:2000 for IgG1, 1:3000 for IgG2, IgG3 and IgG4 in dilution buffer and incubated for one hour at room temperature.

Localization (1:3000) of IgG1

17) Confidence 0.24 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.06 Pain Relevance 0

The following monoclonal mouse anti-human subclasses were used: clone NL16 for IgG1 (Sky lab), clone NP6002 for IgG2 (Sigma), clone ZG4 for IgG3 (Sky lab) and clone RJ4 for IgG4 (Sky lab).

Localization (used) of IgG1

18) Confidence 0.24 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0 Pain Relevance 0

The cell line KA8 secretes an IgG1 (kappa-light chain) immunoglobulin.

Localization (secretes) of IgG1

19) Confidence 0.17 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1851205 Disease Relevance 0 Pain Relevance 0.49

We previously demonstrated that IL-10-treated dendritic cells (DCs) can abrogate asthmatic responses in mice, including airway hyperresponsiveness (AHR), eosinophilia, Th2 cytokine secretion, and serum IgE/IgG1.

Localization (secretion) of IgG1 in DCs associated with asthma, eosinophilia and cytokine

20) Confidence 0.16 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.56 Pain Relevance 0.10

General Comments

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