INT92234

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 8.37
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
tears 2
blood 1
spinal nerve 1
Leukocyte 1
B cells 1
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 315 100.00 Very High Very High Very High
cytokine 221 100.00 Very High Very High Very High
Inflammation 185 100.00 Very High Very High Very High
Arthritis 144 99.84 Very High Very High Very High
Multiple sclerosis 132 99.76 Very High Very High Very High
Inflammatory mediators 18 93.08 High High
Neuritis 1 92.12 High High
rheumatoid arthritis 170 90.12 High High
Opioid 7 87.20 High High
Pain 24 83.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 208 100.00 Very High Very High Very High
Eye Disease 130 100.00 Very High Very High Very High
Necrosis 21 100.00 Very High Very High Very High
Cancer 21 100.00 Very High Very High Very High
Arthropathy 6 100.00 Very High Very High Very High
Obesity 5 100.00 Very High Very High Very High
Arthritis 69 99.84 Very High Very High Very High
Multiple Sclerosis 138 99.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 18 99.68 Very High Very High Very High
Sprains And Strains 1 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, we show a dichotomous effect of DAMGO treatment on IP-10 protein levels expressed by T- and M-tropic HIV-infected PBMCs.
Regulation (effect) of IP-10 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.42 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11086093 Disease Relevance 1.04 Pain Relevance 0.88
EGF, fractalkine/CX3CL1, IL-1Ra, IP-10/CXCL10, and VEGF levels were the only molecules that were determined using the same reagents for both DED and control tears.
Regulation (control) of CXCL10 in tears associated with eye disease
2) Confidence 0.34 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.29 Pain Relevance 0.43
Using a transmigration assay we were able to show that low levels of CXCR3 expression are sufficient to permit a response to the migrational stimulus of the chemokine CXCL10.
Regulation (response) of chemokine CXCL10 associated with chemokine
3) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.47 Pain Relevance 0.34
The CXCL10 immunoreactivity eluted in a single peak between 0.7 M and 1.15 M NaCl, after the CXCL8 peak (data not shown).
Regulation (immunoreactivity) of CXCL10
4) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.15 Pain Relevance 0.21
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies

Leukocyte infiltration during acute and chronic inflammation is regulated by exogenous and endogenous factors, including cytokines, chemokines and proteases.

Regulation (regulated) of CXCL10 in Leukocyte associated with chemokine, inflammation, arthropathy and cytokine
5) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1779382 Disease Relevance 0.58 Pain Relevance 0.42
TCF2, CXCL10, and FUT4 were all up regulated in the MS samples whereas CDC5L, TNFRSF19 and HLA-DR were down regulated (Table 5).
Regulation (regulated) of CXCL10 associated with multiple sclerosis
6) Confidence 0.22 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.48 Pain Relevance 0.24
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
Regulation (upregulation) of CXCL10 in blood
7) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.24 Pain Relevance 0.12
Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis.

Regulation (targets) of CXCL10 in T cells associated with chemokine, inflammation, juvenile chronic polyarthritis and arthritis
8) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1526593 Disease Relevance 0.64 Pain Relevance 0.55
EGF, fractalkine/CX3CL1, IL-1Ra, IP-10/CXCL10, and VEGF levels were the only molecules that were determined using the same reagents for both DED and control tears.
Regulation (control) of IP-10 in tears associated with eye disease
9) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.30 Pain Relevance 0.43
It is of course possible that other mechanisms for IP10 regulation are at play.
Regulation (regulation) of IP10
10) Confidence 0.12 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 0.77 Pain Relevance 0.37
HIV status did not impact on IP-10 or NAAT test results (data not shown).
Neg (not) Regulation (impact) of IP-10 associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650091 Disease Relevance 0.10 Pain Relevance 0
The upregulation of IP-10 mRNA observed here in monkeys challenged by IL-4 inhalation warrants further investigation to determine the cell type and mechanism of IL-4 regulation of IP-10 in vivo.
Regulation (regulation) of IP-10
12) Confidence 0.09 Published 2002 Journal Genome Biol Section Body Doc Link PMC115222 Disease Relevance 0.06 Pain Relevance 0.08
Since chemokines may be released into CSF from inflamed spinal nerve roots, we studied the concentrations of the chemokines MCP-1, MIP-1beta, MIP-3beta, IP-10, SDF-1alpha, RANTES, and SLC in the CSF by sandwich ELISA in patients over the course of GBS and CIDP, before and after immunomodulatory treatment.
Regulation (concentrations) of IP-10 in spinal nerve associated with chemokine, chronic inflammatory demyelinating polyradiculoneuropathy and syndrome
13) Confidence 0.07 Published 2003 Journal J. Clin. Immunol. Section Abstract Doc Link 12959218 Disease Relevance 1.28 Pain Relevance 0.44
Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.


Regulation (regulated) of CXCL10 in B cells associated with multiple sclerosis
14) Confidence 0.06 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2227948 Disease Relevance 0.28 Pain Relevance 0.14
The increase in walking distance was dependent on both BMI and genotype for single nucleotide polymorphisms in the genes encoding the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin (IL)-1beta and the anti-inflammatory cytokine IL-10 (detected using amplification refractory mutation system polymerase chain reaction).
Regulation (dependent) of cytokine IL-10 associated with necrosis, inflammation, cancer, obesity and cytokine
15) Confidence 0.02 Published 2007 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 17600695 Disease Relevance 1.71 Pain Relevance 0.42

General Comments

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