INT92236

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 7.12
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
endothelial cells 3
lymphocyte 2
Leukocyte 1
fibroblasts 1
mesenchymal cells 1
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 169 100.00 Very High Very High Very High
Inflammation 86 100.00 Very High Very High Very High
rheumatoid arthritis 132 98.98 Very High Very High Very High
spinal inflammation 114 98.82 Very High Very High Very High
Arthritis 264 98.24 Very High Very High Very High
chemokine 181 97.64 Very High Very High Very High
Osteoarthritis 6 89.48 High High
Opioid 7 89.20 High High
agonist 1 80.16 Quite High
Enkephalin 1 78.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 93 100.00 Very High Very High Very High
Arthropathy 18 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 99.20 Very High Very High Very High
Rheumatoid Arthritis 132 98.98 Very High Very High Very High
Low Back Pain 114 98.82 Very High Very High Very High
Sprains And Strains 1 98.52 Very High Very High Very High
Seronegative Spondarthritis 102 98.24 Very High Very High Very High
Rheumatic Diseases 12 97.52 Very High Very High Very High
Cancer 81 97.16 Very High Very High Very High
Arthritis 162 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, we show a dichotomous effect of DAMGO treatment on IP-10 protein levels expressed by T- and M-tropic HIV-infected PBMCs.
Regulation (effect) of Gene_expression (expressed) of IP-10 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.42 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11086093 Disease Relevance 1.05 Pain Relevance 0.89
The CXCL10 concentrations in the culture supernatants, therefore, despite the lower doses of IFN-?
Regulation (therefore) of Gene_expression (concentrations) of CXCL10
2) Confidence 0.40 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.16
In order to obtain more insight into CXCL10 processing and the role of CXCL10 and CD26/DPP IV in various rheumatic diseases, including psoriatic arthritis (PsA), ankylosing spondylitis (AS) and RA, the synergistic interaction between cytokines to regulate CXCL10 and CD26/DPP IV expression in fibroblasts and endothelial cells was investigated.
Spec (investigated) Regulation (regulate) of Gene_expression (expression) of CXCL10 in endothelial cells associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, rheumatic diseases, cytokine and arthritis
3) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.50 Pain Relevance 1.02
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies

Leukocyte infiltration during acute and chronic inflammation is regulated by exogenous and endogenous factors, including cytokines, chemokines and proteases.

Regulation (regulated) of in Leukocyte Gene_expression (Coexpression) of CXCL10 in mesenchymal cells associated with chemokine, inflammation, arthropathy and cytokine
4) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1779382 Disease Relevance 0.58 Pain Relevance 0.42
On the other hand, IL-12 down-regulated NBEC production of CXCL10, pointing to the complex modulation of angiogenesis-related gene expression operated by the cytokine.
Regulation (regulated) of Gene_expression (production) of CXCL10 associated with cytokine
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.86 Pain Relevance 0.17
did not result in a significant synergistic CXCL10 production.
Neg (not) Regulation (result) of Gene_expression (production) of CXCL10
6) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.06 Pain Relevance 0.20
The regulated production of the lymphocyte chemoattractant CXCL10 was compared with the induction of the neutrophil chemotactic protein CXCL8, and synovial concentrations of both chemokines were compared in RA, PsA, AS and crystal-induced arthritis (CA).


Regulation (regulated) of Gene_expression (production) of CXCL10 in lymphocyte associated with spinal inflammation, chemokine, rheumatoid arthritis and arthritis
7) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.57 Pain Relevance 1.04
In order to obtain more insight into CXCL10 processing and the role of CXCL10 and CD26/DPP IV in various rheumatic diseases, including psoriatic arthritis (PsA), ankylosing spondylitis (AS) and RA, the synergistic interaction between cytokines to regulate CXCL10 and CD26/DPP IV expression in fibroblasts and endothelial cells was investigated.
Spec (investigated) Regulation (regulate) of in fibroblasts Gene_expression (expression) of CXCL10 in endothelial cells associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, rheumatic diseases, cytokine and arthritis
8) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.50 Pain Relevance 1.02

General Comments

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