INT92237

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 43
Total Number 51
Disease Relevance 43.67
Pain Relevance 13.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
fibroblasts 10
Tears 8
plasma 6
monocytes 6
astrocytes 6
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1109 100.00 Very High Very High Very High
opioid receptor 1 99.98 Very High Very High Very High
Fibrositis 291 99.84 Very High Very High Very High
cytokine 752 99.16 Very High Very High Very High
rheumatoid arthritis 458 97.76 Very High Very High Very High
Inflammation 442 97.60 Very High Very High Very High
Opioid 9 96.80 Very High Very High Very High
Arthritis 334 96.04 Very High Very High Very High
Central nervous system 20 95.64 Very High Very High Very High
agonist 14 90.72 High High
Disease Link Frequency Relevance Heat
Cancer 72 100.00 Very High Very High Very High
Necrosis 68 100.00 Very High Very High Very High
Apoptosis 37 100.00 Very High Very High Very High
Skin Cancer 3 100.00 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 23 99.88 Very High Very High Very High
Dengue 602 99.84 Very High Very High Very High
Fibromyalgia 297 99.84 Very High Very High Very High
Infection 741 99.72 Very High Very High Very High
Systemic Lupus Erythematosus 298 99.66 Very High Very High Very High
Hepatitis C Virus Infection 1240 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of upstream apoptotic regulators like pJNK, p38 and Bax was established on the basis of their increased expression of CXCL10.
Positive_regulation (increased) of Gene_expression (expression) of CXCL10 associated with apoptosis
1) Confidence 0.70 Published 2010 Journal Int J Exp Pathol Section Abstract Doc Link 20041963 Disease Relevance 1.15 Pain Relevance 0.12
It is plausible that the increased expression of CXCL10 and CXCL8 by HCV core-exposed microglia and astrocytes might enhance recruitment of T helper cells and monocytes in the brain, leading to deleterious effects.
Positive_regulation (increased) of Gene_expression (expression) of CXCL10 in astrocytes associated with hepatitis c virus infection
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.24 Pain Relevance 0.05
were rather weak inducers of CXCL10 (1–5 ng/ml) in fibroblasts as single agents, all combinations provided a dose-dependent synergistic induction yielding a 3-fold to 30-fold increase of CXCL10 production (5–150 ng/ml) (Figures 1 and 2, left panels).
Positive_regulation (increase) of Gene_expression (production) of CXCL10 in fibroblasts
3) Confidence 0.61 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.14 Pain Relevance 0.17
resulted in more than 10-fold increased CXCL10 protein production.
Positive_regulation (increased) of Gene_expression (production) of CXCL10 protein
4) Confidence 0.61 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.23 Pain Relevance 0.35
did not induce CXCL10 production in fibroblasts or HMVEC, the combined treatment of these cells with IFN-?
Neg (not) Positive_regulation (induce) of Gene_expression (production) of CXCL10 in fibroblasts
5) Confidence 0.61 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.47 Pain Relevance 0.51
resulted in a more modest synergistic increase of CXCL10 production.
Positive_regulation (increase) of Gene_expression (production) of CXCL10
6) Confidence 0.61 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.07 Pain Relevance 0.21
to drastically enhance the production of CXCL10 by fibroblasts and to inhibit IFN-?
Positive_regulation (enhance) of Gene_expression (production) of CXCL10 in fibroblasts
7) Confidence 0.61 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.22 Pain Relevance 0.23
Significantly increased IP-10/CXCL10 expression in both corneal and conjunctival epithelium has been described in an experimental animal model of dry eye [61] and more recently in tears from Sjögren Syndrome DED patients, and also, but non significantly, in non-Sjögren DED patients [51].
Positive_regulation (increased) of Gene_expression (expression) of IP-10 in tears associated with disorders of the lacrimal system, syndrome and eye disease
8) Confidence 0.52 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.69 Pain Relevance 0.30
CXCL10 and interleukin-8) expression was observed in both microglia and astrocytes (p<0.05).
Positive_regulation (observed) of Gene_expression (expression) of CXCL10 in astrocytes
9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.69 Pain Relevance 0.21
Increased expression of CXCL10 and CXCL8 in astrocytes was also reported in brains of individuals with HIV encephalitis [64].
Positive_regulation (Increased) of Gene_expression (expression) of CXCL10 in brains associated with acquired immune deficiency syndrome or hiv infection and viral meningitis
10) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.45 Pain Relevance 0.06
The lining endothelial cells of capillaries, in direct contact with the target leukocytes in the bloodstream, are therefore an important CXCL8 and CXCL10 source.
Positive_regulation (important) of Gene_expression (source) of CXCL10 in endothelial cells
11) Confidence 0.44 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.12
Similarly, transcript levels of CXCL10 and CXCL8 in HFAs were increased at 6 and 12 hr after HCV core protein application (Figure 3B and 3D, p<0.05).
Positive_regulation (increased) of Gene_expression (levels) of CXCL10 associated with hepatitis c virus infection
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.07 Pain Relevance 0.27
synergistically stimulate production of CXCL10.
Positive_regulation (stimulate) of Gene_expression (production) of CXCL10
13) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.09 Pain Relevance 0.21
Tears from the DED patients had significantly increased IP-10/CXCL10 levels.
Positive_regulation (increased) of Gene_expression (levels) of IP-10 in Tears associated with eye disease
14) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.85 Pain Relevance 0.40
Tears from the DED patients had significantly increased IP-10/CXCL10 levels.
Positive_regulation (increased) of Gene_expression (levels) of CXCL10 in Tears associated with eye disease
15) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.85 Pain Relevance 0.40
Significantly increased IP-10/CXCL10 expression in both corneal and conjunctival epithelium has been described in an experimental animal model of dry eye [61] and more recently in tears from Sjögren Syndrome DED patients, and also, but non significantly, in non-Sjögren DED patients [51].
Positive_regulation (increased) of Gene_expression (expression) of CXCL10 in tears associated with disorders of the lacrimal system, syndrome and eye disease
16) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.69 Pain Relevance 0.30
in the serum in response to dsRNA, we did detect enhanced levels of CXCL10.
Positive_regulation (enhanced) of Gene_expression (levels) of CXCL10
17) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.05 Pain Relevance 0.10
Moreover, cultured dental pulp fibroblasts produced CXCL10 after stimulation with live caries-related bacteria, peptidoglycans, and pro-inflammatory cytokines.
Positive_regulation (after) of Gene_expression (produced) of CXCL10 in dental pulp associated with inflammation and cytokine
18) Confidence 0.34 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 18037659 Disease Relevance 0.45 Pain Relevance 0.51
Measurement of CXCL10 concentrations
Positive_regulation (Measurement) of Gene_expression (concentrations) of CXCL10
19) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0 Pain Relevance 0.16
Only a single patient with SLE showed slightly increased levels of CXCL10.


Positive_regulation (increased) of Gene_expression (levels) of CXCL10 associated with systemic lupus erythematosus
20) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.41 Pain Relevance 0.37

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