INT92245

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Context Info
Confidence 0.06
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.68
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgg) extracellular space (Fgg) extracellular region (Fgg)
protein binding, bridging (Fgg)
Anatomy Link Frequency
plasma 2
platelet 2
hemolymph 1
cleavage 1
endothelium 1
Fgg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 121 99.74 Very High Very High Very High
imagery 3 98.00 Very High Very High Very High
beta blocker 1 97.42 Very High Very High Very High
cva 35 95.16 Very High Very High Very High
Pain 4 88.56 High High
addiction 2 69.76 Quite High
Inflammatory response 27 61.44 Quite High
rheumatoid arthritis 64 61.24 Quite High
antagonist 2 56.64 Quite High
ischemia 18 55.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 166 99.74 Very High Very High Very High
Alzheimer's Dementia 1 99.52 Very High Very High Very High
Stroke 115 99.50 Very High Very High Very High
Increased Venous Pressure Under Development 58 99.32 Very High Very High Very High
Injury 22 99.28 Very High Very High Very High
Anaemia 2 99.06 Very High Very High Very High
Weight Loss 5 98.76 Very High Very High Very High
Sepsis 16 98.46 Very High Very High Very High
Cirrhosis 1 98.04 Very High Very High Very High
Disseminated Intravascular Coagulation 5 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suggested mechanisms include reduced plasma fibrinogen levels (Lakka and Salonen 1993) and other positive rheologic effects of exercise (Eichner 1990) that may potentially even reverse the negative impact of chronic low-grade inflammation.
Negative_regulation (reduced) of fibrinogen in plasma associated with inflammation
1) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.12 Pain Relevance 0.08
The diagnosis of stroke was made blinded to the measurement of CRP, IL-6, and fibrinogen.


Negative_regulation (measurement) of fibrinogen associated with stroke
2) Confidence 0.06 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 1.66 Pain Relevance 0.30
Cover slips were incubated with a suspension of fibrinogen (100 ?
Negative_regulation (suspension) of fibrinogen
3) Confidence 0.04 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.10 Pain Relevance 0
Ancrod-mediated cleavage of fibrinogen followed by removal of fibrin fragments via the reticulo-endothelial system is known to trigger fibrinogen depletion [28], and this condition reduced the staphylococcal burden in a murine air pouch model [27].
Negative_regulation (depletion) of fibrinogen in cleavage
4) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.57 Pain Relevance 0
For EBOV, rodents do not display all the characteristics of disseminated intravascular coagulation (DIC) that filovirus-infected nonhuman primates show including prolongation of PT and aPTT, circulating fibrin degredation products (FDPs), decreased plasma fibrinogen, and increased tissue fibrin deposition [32].
Negative_regulation (decreased) of fibrinogen in plasma associated with ebola virus infection and disseminated intravascular coagulation
5) Confidence 0.02 Published 2007 Journal Virol J Section Body Doc Link PMC2164958 Disease Relevance 0.88 Pain Relevance 0.03
Subcutaneous injection of crude hemolymph and some chromatographic fractions of LA induce a decrease in fibrinogen, plasminogen and factor XIII.
Negative_regulation (decrease) of fibrinogen in hemolymph
6) Confidence 0.01 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.43 Pain Relevance 0.07
Hematological tests show: mild anemia with leucocytosis; prolonged PT, PTT and ThT; decreased fibrinogen, factor V, factor XIII, plasminogen and alpha2-antiplasmin levels; increased factor VIII:c, von Willebrand factor, and FDPs/D-dimers levels with normal ATIII and platelets.
Negative_regulation (decreased) of fibrinogen in platelets associated with anaemia
7) Confidence 0.01 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.72 Pain Relevance 0.14
TF blockade has shown protective effects when administered at the onset of sepsis and given as a rescue therapy, decreasing systemic inflammation, preventing fibrinogen depletion, and attenuating injury to the lung, kidney, and other organs [4], [14], [15].
Negative_regulation (depletion) of fibrinogen in kidney associated with inflammation, injury and sepsis
8) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 1.09 Pain Relevance 0.24
Both testosterone administration and anabolic steroid use seem to decrease PAI-1 and fibrinogen in men and women, attesting to androgens' anticoagulatory and fibrinolytic effects [16,17,29,40].
Negative_regulation (decrease) of fibrinogen
9) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2693125 Disease Relevance 0.43 Pain Relevance 0.07
activation inhibits inflammatory gene expression by downregulation of acute phase proteins such as C-reactive protein (CRP), fibrinogen, and serum amyloid A (SAA) resulting in reduced hepatic inflammation and risk for cardiovascular disease and cancer [85].
Negative_regulation (downregulation) of fibrinogen associated with cirrhosis, inflammation, cancer, cardiovascular disease and alzheimer's dementia
10) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.60 Pain Relevance 0.13
For example, when irbesartan has been compared with the beta-blocker atenolol, results have shown that both were able to improve endothelium-dependent vasodilation, but only irbesartan was able to reduce fibrinogen, PAI-1, and thrombomodulin.
Negative_regulation (reduce) of fibrinogen in endothelium associated with beta blocker and increased venous pressure under development
11) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.59 Pain Relevance 0.05
These alterations, in turn, could explain the observed decrease in platelet count and fibrinogen level and subsequent increase in thrombin-antithrombin III complex, prothrombin fragment F1+2, and D-dimer concentrations [11].
Negative_regulation (decrease) of fibrinogen in platelet
12) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.41 Pain Relevance 0
TF blockade has shown protective effects when administered at the onset of sepsis and given as a rescue therapy, decreasing systemic inflammation, preventing fibrinogen depletion, and attenuating injury to the lung, kidney, and other organs [4], [14], [15].
Negative_regulation (depletion) of fibrinogen in lung associated with inflammation, injury and sepsis
13) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 1.09 Pain Relevance 0.24

General Comments

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