INT92249

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Context Info
Confidence 0.46
First Reported 2000
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 4.97
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FDPS) mitochondrion (FDPS) small molecule metabolic process (FDPS)
nucleolus (FDPS) nucleus (FDPS) cytoplasm (FDPS)
Anatomy Link Frequency
osteoclasts 3
platelets 1
FDPS (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 2 91.96 High High
Potency 5 87.64 High High
Pain 16 85.36 High High
Central nervous system 6 67.32 Quite High
pregabalin 117 50.00 Quite Low
Neurobehavioral 3 15.68 Low Low
gABA 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Onset of action 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 123 98.86 Very High Very High Very High
Anaemia 1 97.46 Very High Very High Very High
Cancer 18 96.78 Very High Very High Very High
Ovarian Cancer 3 95.56 Very High Very High Very High
Apoptosis 13 95.32 Very High Very High Very High
Breast Cancer 9 93.48 High High
Renal Failure 1 93.32 High High
Cv General 3 Under Development 2 91.96 High High
Stress 42 89.36 High High
Hematuria 1 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The FPS experiment contained three different contexts in which instructions regarding possible shock administration varied (Grillon et al. 2004, 2006).
Gene_expression (experiment) of FPS associated with shock
1) Confidence 0.46 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.91 Pain Relevance 0.03
After this, the shock electrodes were placed, and instructions concerning the FPS experiment were given.
Gene_expression (experiment) of FPS associated with shock
2) Confidence 0.46 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.96 Pain Relevance 0.03
Earlier studies showed that the benzodiazepines oxazepam (15 and 30 mg) and diazepam (4, 10 and 15 mg) were not effective in reducing FPS in three different experiments (Baas et al. 2002a).
Gene_expression (reducing) of FPS
3) Confidence 0.46 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.63 Pain Relevance 0
In the absence of FPP synthase, FPP and geranylgeranyl diphosphate are not produced, which results in the inhibition of the GTP-binding proteins prenylation in osteoclasts.
Neg (not) Gene_expression (produced) of FPP in osteoclasts
4) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682377 Disease Relevance 0.41 Pain Relevance 0.04
Hematological tests show: mild anemia with leucocytosis; prolonged PT, PTT and ThT; decreased fibrinogen, factor V, factor XIII, plasminogen and alpha2-antiplasmin levels; increased factor VIII:c, von Willebrand factor, and FDPs/D-dimers levels with normal ATIII and platelets.
Gene_expression (levels) of FDPs in platelets associated with anaemia
5) Confidence 0.29 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.71 Pain Relevance 0.13
In the absence of FPP synthase, FPP and geranylgeranyl diphosphate are not produced, which results in the inhibition of the GTP-binding proteins prenylation in osteoclasts.
Neg (not) Gene_expression (produced) of FPP synthase in osteoclasts
6) Confidence 0.14 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682377 Disease Relevance 0.42 Pain Relevance 0.04
The anti-tumor effect of alendronate, ZOL and PAM was correlated to their inhibition of the MWA pathway in prostate cells [15,17], favoring the hypothesis of an inhibition of FPP synthesis, protein geranyl-geranylation was not assessed although GGOH appeared more effective than FOH to rescue ZOL-induced apoptosis.
Gene_expression (synthesis) of FPP associated with cancer and apoptosis
7) Confidence 0.06 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.43 Pain Relevance 0
Conversely, recent in vivo studies suggested that the inhibition of the mevalonate pathway by N-BPs lies downstream the FPP synthesis step; indeed, several cellular effects of N-BPs such as inhibition of osteoclast formation[10], inhibition of ovarian cancer cell migration [11] or inhibition of breast cancer cell invasion [12] were reversed only by GGOH but not by FOH.
Gene_expression (synthesis) of FPP in osteoclast associated with breast cancer and ovarian cancer
8) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.28 Pain Relevance 0.03
So, inhibition of geranyl-geranylation by ZOL appears to result from a blockade in GGPP synthesis from FPP rather than from the inhibition of the enzymatic transfer of GGPP onto its protein substrate.


Gene_expression (synthesis) of FPP
9) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.22 Pain Relevance 0

General Comments

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