INT92291

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Context Info
Confidence 0.73
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.06
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR1) signal transducer activity (CXCR1)
Anatomy Link Frequency
monocyte 1
endometrium 1
neutrophils 1
CXCR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 7 100.00 Very High Very High Very High
Glutamate 2 97.94 Very High Very High Very High
Calcium channel 1 92.36 High High
Inflammation 13 92.24 High High
gABA 1 90.52 High High
cytokine 6 85.28 High High
Gabapentin 1 82.36 Quite High
aspirin 5 75.00 Quite High
cINOD 1 71.40 Quite High
antagonist 1 58.16 Quite High
Disease Link Frequency Relevance Heat
Leukemia 1 99.60 Very High Very High Very High
Gastritis 5 97.44 Very High Very High Very High
Duodenal Ulcer 3 96.88 Very High Very High Very High
Infection 39 95.20 Very High Very High Very High
Gastroesophageal Reflux Disease 76 93.52 High High
INFLAMMATION 17 92.24 High High
Neurodegenerative Disease 2 84.68 Quite High
Apoptosis 6 84.32 Quite High
Motor Neuron Diseases 6 80.92 Quite High
Brain Injury 1 79.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In parallel experiments involving human colonic mucosa ex vivo, LXA(4)potently attenuated TNF-alpha-stimulated release of the C-X-C chemokine IL-8, and the C-C chemokines monocyte-chemoattractant protein-1 (MCP-1) and RANTES.
Localization (release) of C-C in monocyte associated with chemokine
1) Confidence 0.73 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11509622 Disease Relevance 0.44 Pain Relevance 0.51
MAIN OUTCOME MEASURE(S): Microscopic evaluation to assess the presence and localization of CXCR1 and CXCR2 throughout the menstrual cycle in both eutopic endometrial and adenomyotic tissues of women with adenomyosis and compare it with normal endometrium.
Localization (localization) of CXCR1 in endometrium
2) Confidence 0.67 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16500343 Disease Relevance 0.08 Pain Relevance 0
But, their expression is dependent on the corresponding expression of their receptors (CXCR1 and CXCR2) on neutrophils.95 IL-8 may influence development of gastritis and duodenal ulcer in patients with H. pylori infection.96,97
Localization (receptors) of CXCR1 in neutrophils associated with duodenal ulcer, gastritis and infection
3) Confidence 0.09 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912116 Disease Relevance 1.50 Pain Relevance 0.21
A broader range of mechanisms is represented by compounds in Phase I trials: glutamate antagonism (dextramethorphan/p450 inhibitor; talampanel), growth factors (leukemia inhibiting factor; IL-1 receptor; encapsulated cells secreting CNTF) and antioxidants (TR500, a glutathione-repleting agent; recombinant superoxide dismutase; procysteine.)
Localization (secreting) of IL-1 receptor associated with leukemia and glutamate
4) Confidence 0.02 Published 2000 Journal J. Neurol. Sci. Section Abstract Doc Link 11090860 Disease Relevance 1.04 Pain Relevance 0.27

General Comments

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