INT923

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Context Info
Confidence 0.43
First Reported 1979
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 18
Disease Relevance 2.48
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
gonadal 10
plasma 6
follicle 6
gonadotrophs 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 27 100.00 Very High Very High Very High
Opioid 9 100.00 Very High Very High Very High
opiate 6 99.96 Very High Very High Very High
antagonist 17 99.46 Very High Very High Very High
Clonidine 6 97.52 Very High Very High Very High
Dopamine 11 95.92 Very High Very High Very High
dopamine receptor 3 91.96 High High
agonist 3 91.12 High High
Neurotransmitter 4 90.96 High High
Serotonin 5 90.08 High High
Disease Link Frequency Relevance Heat
Reprotox - General 1 5 99.84 Very High Very High Very High
Acth-secreting Pituitary Adenoma 3 96.56 Very High Very High Very High
Hypertension 1 95.68 Very High Very High Very High
Cancer 5 91.16 High High
Pituitary Cancer 3 78.96 Quite High
Breast Cancer 1 77.60 Quite High
Uterine Fibroids 1 76.32 Quite High
Eating Disorder 1 75.00 Quite High
Polycystic Ovary Syndrome 1 75.00 Quite High
Galactorrhea 1 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In tissue culture, the second, third, and fourth specimens released ACTH, alpha-subunit, FSH, and LH and responded to corticotropin-releasing hormone with increased release of ACTH, alpha-subunit, FSH, and LH.
Positive_regulation (increased) of Localization (release) of FSH
1) Confidence 0.43 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1649119 Disease Relevance 0.88 Pain Relevance 0.07
The results obtained point also to a possible different pattern of LH and FSH secretion after naloxone, that is after opiate receptor blockade.
Positive_regulation (after) of Localization (secretion) of FSH associated with narcan and opiate
2) Confidence 0.41 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 223091 Disease Relevance 0 Pain Relevance 0.93
The plasma beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) response to acute exercise and the relationship of these opioid peptides to basal and luteinizing hormone-releasing hormone (LRH)-stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion was studied in eight normal male volunteers.
Positive_regulation (response) of in follicle Localization (secretion) of FSH in plasma associated with opioid
3) Confidence 0.35 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.10
The plasma beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) response to acute exercise and the relationship of these opioid peptides to basal and luteinizing hormone-releasing hormone (LRH)-stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion was studied in eight normal male volunteers.
Positive_regulation (-stimulated) of Localization (secretion) of FSH in plasma associated with opioid
4) Confidence 0.35 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.10
The plasma beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) response to acute exercise and the relationship of these opioid peptides to basal and luteinizing hormone-releasing hormone (LRH)-stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion was studied in eight normal male volunteers.
Positive_regulation (response) of in follicle Localization (secretion) of follicle-stimulating hormone in plasma associated with opioid
5) Confidence 0.35 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.10
The plasma beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) response to acute exercise and the relationship of these opioid peptides to basal and luteinizing hormone-releasing hormone (LRH)-stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion was studied in eight normal male volunteers.
Positive_regulation (-stimulated) of Localization (secretion) of follicle-stimulating hormone in plasma associated with opioid
6) Confidence 0.35 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.10
Since the angiotensin converting enzyme can participate in the metabolism of opioid peptides, this study examined the action of Captopril, an angiotensin converting enzyme inhibitor, on corticotropin and gonadotropin (LH and FSH) release induced by the opiate antagonist naloxone in man.
Positive_regulation (induced) of Localization (release) of FSH associated with antagonist, narcan, opiate and opioid
7) Confidence 0.22 Published 1993 Journal Horm. Metab. Res. Section Abstract Doc Link 8262463 Disease Relevance 0.10 Pain Relevance 0.71
At the onset of puberty, the hypothalamus, after being quiescent, resumes a marked pulsatile secretion of Gonadotrophine Releasing Hormone (GnRH), leading to an increased secretion of pituitary gonadotropines (Luteinizing Hormone [LH], and Follicle Stimulating Hormone [FSH]), especially during night, which in turn stimulates the gonadal functions.
Positive_regulation (increased) of Localization (secretion) of Stimulating Hormone in gonadal
8) Confidence 0.20 Published 2006 Journal Scoliosis Section Body Doc Link PMC1501058 Disease Relevance 0 Pain Relevance 0.21
At the onset of puberty, the hypothalamus, after being quiescent, resumes a marked pulsatile secretion of Gonadotrophine Releasing Hormone (GnRH), leading to an increased secretion of pituitary gonadotropines (Luteinizing Hormone [LH], and Follicle Stimulating Hormone [FSH]), especially during night, which in turn stimulates the gonadal functions.
Positive_regulation (leading) of Localization (secretion) of Stimulating Hormone in gonadal
9) Confidence 0.20 Published 2006 Journal Scoliosis Section Body Doc Link PMC1501058 Disease Relevance 0 Pain Relevance 0.21
Naloxone stimulated LH and cortisol secretion in all subjects, whereas FSH, TSH, PRL, and GH did not change.
Positive_regulation (stimulated) of Localization (secretion) of FSH associated with narcan
10) Confidence 0.17 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6847869 Disease Relevance 0 Pain Relevance 0.77
Cimetidine had no effect on the GH, PRL, or cortisol response to insulin-induced hypolycemia or the 24-h secretion of LH, FSH, testosterone, or PRL.
Positive_regulation (response) of Localization (secretion) of FSH
11) Confidence 0.17 Published 1979 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 113425 Disease Relevance 0.37 Pain Relevance 0.12
At the onset of puberty, the hypothalamus, after being quiescent, resumes a marked pulsatile secretion of Gonadotrophine Releasing Hormone (GnRH), leading to an increased secretion of pituitary gonadotropines (Luteinizing Hormone [LH], and Follicle Stimulating Hormone [FSH]), especially during night, which in turn stimulates the gonadal functions.
Positive_regulation (increased) of Localization (secretion) of FSH in gonadal
12) Confidence 0.16 Published 2006 Journal Scoliosis Section Body Doc Link PMC1501058 Disease Relevance 0 Pain Relevance 0.21
At the onset of puberty, the hypothalamus, after being quiescent, resumes a marked pulsatile secretion of Gonadotrophine Releasing Hormone (GnRH), leading to an increased secretion of pituitary gonadotropines (Luteinizing Hormone [LH], and Follicle Stimulating Hormone [FSH]), especially during night, which in turn stimulates the gonadal functions.
Positive_regulation (leading) of Localization (secretion) of FSH in gonadal
13) Confidence 0.16 Published 2006 Journal Scoliosis Section Body Doc Link PMC1501058 Disease Relevance 0 Pain Relevance 0.21
OBJECTIVE: To determine if chronic treatment with the long-acting oral opioid antagonist naltrexone can increase luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in women with secondary amenorrhea.
Positive_regulation (increase) of Localization (secretion) of follicle-stimulating hormone in follicle associated with antagonist, opioid and reprotox - general 1
14) Confidence 0.06 Published 1992 Journal Fertil. Steril. Section Abstract Doc Link 1555686 Disease Relevance 0.32 Pain Relevance 0.15
The LHRH antagonist D-pGlu1, D-Phe2,D-Trp3,6-LHRH blocked the secretion of Dyn A1-13-IR, LH, and FSH induced by hpGHRH-(1-44), whereas the LHRH antagonist did not influence the simultaneous GH release elicited by hpGHRH-(1-44).
Positive_regulation (induced) of Localization (secretion) of FSH associated with antagonist
15) Confidence 0.06 Published 1987 Journal Endocrinology Section Abstract Doc Link 2879724 Disease Relevance 0 Pain Relevance 0.31
High concentrations of GHRH may interact directly with LHRH receptors on gonadotrophs and thereby enhance the release of LH, FSH, and Dyn A1-13-IR.
Spec (may) Positive_regulation (enhance) of Localization (release) of FSH in gonadotrophs
16) Confidence 0.06 Published 1987 Journal Endocrinology Section Abstract Doc Link 2879724 Disease Relevance 0 Pain Relevance 0.13
This action leads to the secretion of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that in turn act on the reproductive organs regulating gonadal steroid production, spermatogenesis and follicular development.
Positive_regulation (leads) of Localization (secretion) of follicle-stimulating hormone in gonadal
17) Confidence 0.05 Published 2004 Journal Curr. Med. Chem. Section Abstract Doc Link 15544487 Disease Relevance 0.50 Pain Relevance 0.25
The increase in prolactin level is probably not directly involved in normal secretion of LH and follicle stimulating hormone (FSH) at ovulation.
Positive_regulation (increase) of Localization (secretion) of stimulating hormone in follicle
18) Confidence 0.01 Published 1980 Journal J. Reprod. Fertil. Section Abstract Doc Link 6776267 Disease Relevance 0.31 Pain Relevance 0.27

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