INT9230

Context Info Confidence 0.78 First Reported 1992 Last Reported 2010 Negated 2 Speculated 2 Reported most in Abstract Documents 43 Total Number 45 Disease Relevance 10.54 Pain Relevance 18.81

plasma membrane (Htr3a) cytoplasm (Htr3a)

Anatomy Link Frequency neurons 4 oocytes 3 interstitial cells 2 sensory neurons 2 aorta 1 Htr3a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 106 100.00 agonist 87 100.00 antagonist 62 100.00 Serotonin 32 100.00 qutenza 24 100.00 intrathecal 2 99.98 Somatostatin 11 99.96 Morphine 13 99.68 nociceptor 26 99.52 nMDA receptor 1 99.44

Disease Link Frequency Relevance Heat Pain 110 100.00 Ganglion Cysts 56 99.36 Injury 10 99.16 Nervous System Injury 15 98.92 Nociception 53 98.84 Post-operative Nausea 2 98.40 Hyperalgesia 20 97.92 Hyperglycemia 4 97.84 Vomiting 10 96.44 Functional Bowel Disorder 13 96.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The aim of the present study was to establish a radioligand binding assay to selectively label the native 5-HT7 receptor expressed in rat brain.

Gene_expression (expressed) of 5-HT7 receptor in brain

1) Confidence 0.78 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9886684 Disease Relevance 0 Pain Relevance 0.07

Thus, the 5-HT1B receptor mRNA detected in tissue extracts of the rat aorta most likely reflects 5-HT1B receptor expression in the arterioles of the vasa vasorum.

Gene_expression (expression) of 5-HT1B receptor in aorta

2) Confidence 0.75 Published 2002 Journal Recept. Channels Section Abstract Doc Link 12448788 Disease Relevance 0 Pain Relevance 0.45

Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying.

Gene_expression (Expression) of 5-HT3

3) Confidence 0.75 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 12409280 Disease Relevance 0 Pain Relevance 0.13

Expression of 5-HT3 receptors in the rat gastrointestinal tract.

Gene_expression (Expression) of 5-HT3 associated with qutenza

4) Confidence 0.75 Published 2002 Journal Gastroenterology Section Title Doc Link 12105850 Disease Relevance 0.17 Pain Relevance 0.15

We previously demonstrated that ginseng total saponins (GTS, also called ginsenosides), the active ingredients of Panax ginseng, inhibit the activity of 5-HT3A receptor channels expressed in Xenopus laevis oocytes.

Gene_expression (expressed) of 5-HT3A in oocytes

5) Confidence 0.75 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16272701 Disease Relevance 0.29 Pain Relevance 0.45

The aim of the present study was to elucidate the cellular sites of 5-HT3R expression in the rat GI tract using immunohistochemistry.

Gene_expression (expression) of 5-HT3R

6) Confidence 0.75 Published 2002 Journal Gastroenterology Section Abstract Doc Link 12105850 Disease Relevance 0.19 Pain Relevance 0.05

CONCLUSIONS: These findings indicate that 5-HT3Rs are expressed by distinct cells in the GI tract, including functionally distinct classes of neurons, interstitial cells of Cajal, and endocrine cells.

Gene_expression (expressed) of 5-HT3R in neurons

7) Confidence 0.75 Published 2002 Journal Gastroenterology Section Body Doc Link 12105850 Disease Relevance 0 Pain Relevance 0

Although serotoninergic fibers usually do not contact PSA-NCAM immunoreactive neurons, most of these cells express 5-HT3 receptors.

Gene_expression (express) of 5-HT3 in neurons

8) Confidence 0.75 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.28 Pain Relevance 0.76

The expression of 5-HT expression, 5-HT3 receptors, and 5-HT transporter were analyzed by RT-PCR.

Spec (analyzed) Gene_expression (expression) of 5-HT3

9) Confidence 0.75 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17110521 Disease Relevance 0.32 Pain Relevance 0.78

The function of other ligand-gated ion channels, such as the N-methyl-D-aspartate receptor (NR1 + NR2A or 2C) and the 5-HT3 receptor expressed in Xenopus oocytes, were unaffected by OA.

Gene_expression (expressed) of 5-HT3 in oocytes associated with nmda receptor

10) Confidence 0.75 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620523 Disease Relevance 0.06 Pain Relevance 0.38

The effect of morphine on the ion current mediated by 5-hydroxytryptamine (5-HT3) receptors was investigated in rat nodose ganglion neurons and in Xenopus oocytes expressing the cloned 5-HT3 receptor.

Gene_expression (expressing) of 5-HT3 in oocytes associated with ganglion cysts and morphine

11) Confidence 0.75 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7535378 Disease Relevance 0.10 Pain Relevance 0.67

The expression of 5-HT expression, 5-HT3 receptors, and 5-HT transporter were analyzed by RT-PCR.

Gene_expression (expression) of 5-HT3

12) Confidence 0.75 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17110521 Disease Relevance 0.32 Pain Relevance 0.79

Polymerase chain reaction amplification of 5-HT receptor cDNA demonstrates that 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A and 5-HT3, but not the 5-HT2C, receptor subtypes are present in lumbar sympathetic ganglia.

Neg (not) Gene_expression (present) of 5-HT3 in sympathetic

13) Confidence 0.75 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562592 Disease Relevance 0.28 Pain Relevance 0.48

Protein and mRNA expression levels of 5-HT3 receptors and 5-HT transporter were similar in MS and NH rats.

Gene_expression (expression) of 5-HT3

14) Confidence 0.75 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17110521 Disease Relevance 0.15 Pain Relevance 0.67

The aim of the present study was to investigate the participation of the brain CRH component and 5-HT3 receptors in basal blood glucose levels as well as in the hyperglycemia induced by third ventricle injections of fluoxetine, a serotonin reuptake inhibitor with a broad range of clinical use.

Spec (investigate) Gene_expression (participation) of 5-HT3 in blood associated with hyperglycemia, serotonin and fluoxetine

15) Confidence 0.65 Published 2004 Journal Neuropeptides Section Abstract Doc Link 15223272 Disease Relevance 0.42 Pain Relevance 0.47

This effect was attenuated after intrathecal administration of the alpha2-adrenoceptor antagonist yohimbine, the selective 5-HT3 serotonin receptor antagonist MDL72222, and the non-selective serotonin receptor antagonist methysergide.

Gene_expression (administration) of 5-HT3 associated with antagonist, serotonin and intrathecal

16) Confidence 0.65 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18539061 Disease Relevance 0.60 Pain Relevance 1.35

Roles of 5-HT3 receptors and 5-HT in responses to CT

Gene_expression (receptors) of 5-HT3

17) Confidence 0.65 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2967348 Disease Relevance 0 Pain Relevance 0

Intrathecal injections of the selective 5-HT1A, 5-HT1B, 5-HT3 receptor antagonists, WAY 100135, SB-224289, and tropisetron, respectively, and the non-specific antagonist methysergide, were given.

Gene_expression (injections) of 5-HT3 associated with antagonist and intrathecal

18) Confidence 0.65 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165284 Disease Relevance 0.17 Pain Relevance 1.13

We also found that local injection of the 5-HT2A and 5-HT3 receptor antagonists ketanserin and ICS 205-930 into the affected hind paw relieved mechanical hyperalgesia in a dose-dependent fashion.

Gene_expression (injection) of 5-HT3 in paw associated with hyperalgesia and antagonist

19) Confidence 0.65 Published 1999 Journal Pain Section Abstract Doc Link 10431712 Disease Relevance 1.09 Pain Relevance 1.25

Within lumbar dorsal root ganglia, the presence of the 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3 and 5-HT7 receptor subtype messenger RNAs was detected.

Gene_expression (presence) of 5-HT3 in dorsal root ganglia

20) Confidence 0.65 Published 1996 Journal Neuroscience Section Abstract Doc Link 8848158 Disease Relevance 0.07 Pain Relevance 0.18

General Comments

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