INT92311

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.20
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (SIL1) protein folding (SIL1) endoplasmic reticulum (SIL1)
Anatomy Link Frequency
plasma 2
SIL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 159 99.38 Very High Very High Very High
Pain 33 95.96 Very High Very High Very High
Inflammatory marker 5 91.84 High High
cytokine 10 82.48 Quite High
cINOD 1 77.32 Quite High
Morphine 1 72.40 Quite High
analgesia 5 71.84 Quite High
Inflammatory response 25 71.36 Quite High
Arthritis 6 70.96 Quite High
Osteoarthritis 6 68.96 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 24 100.00 Very High Very High Very High
Smith-lemli-opitz Syndrome 12 100.00 Very High Very High Very High
Death 1 99.52 Very High Very High Very High
INFLAMMATION 195 99.38 Very High Very High Very High
Periodontitis 95 98.70 Very High Very High Very High
Multiple Myeloma 4 98.20 Very High Very High Very High
Disease 42 96.60 Very High Very High Very High
Pain 28 95.96 Very High Very High Very High
Osteoporosis 58 95.68 Very High Very High Very High
Intellectual Impairment 2 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of pamidronate on markers of bone resorption [cross-linked N-telopeptides of type I collagen (NTx)], markers of bone formation [serum alkaline phosphatase (BAP) and osteocalcin (OSC)], interleukin-6 (IL-6), beta2-microglobulin, CRP, paraprotein and disease-related pain and skeletal events has been evaluated in 62 newly diagnosed patients with MM.
Regulation (effect) of BAP associated with pain, hypercalcemia, multiple myeloma and disease
1) Confidence 0.44 Published 2000 Journal Eur. J. Haematol. Section Abstract Doc Link 11092464 Disease Relevance 0.83 Pain Relevance 0.10
Most infants affected with MSS succumb to death early in life.
Regulation (affected) of MSS associated with smith-lemli-opitz syndrome and death
2) Confidence 0.25 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2933713 Disease Relevance 1.43 Pain Relevance 0.06
The lack of significant changes in the serum BAP levels may be explained by the slower response of serum BAP to bisphosphonates than that of urinary NTX.32 It was surmised that a reduction in the serum BAP level would be observed after at least 3 months of etidronate treatment.
Regulation (changes) of BAP
3) Confidence 0.12 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815806 Disease Relevance 1.23 Pain Relevance 0.59
We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP.


Spec (determine) Regulation (effects) of BiP associated with periodontitis and inflammation
4) Confidence 0.01 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2065903 Disease Relevance 0.51 Pain Relevance 0.09
Treatment of the gingival inflammation results in a return of HSP10 levels to those found in controls but has no effect on the lowered levels of BiP.
Neg (no) Regulation (effect) of BiP associated with inflammation
5) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.61 Pain Relevance 0.15
Treatment of the periodontitis caused an increase in plasma levels of HSP10 although it had no effect on BiP.
Neg (no) Regulation (effect) of BiP in plasma associated with periodontitis
6) Confidence 0.01 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2065903 Disease Relevance 0.62 Pain Relevance 0.16
Two site ELISAs were used to measure the concentrations of HSP10, HSP60 and BiP in plasma samples.
Regulation (concentrations) of BiP in plasma
7) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.16 Pain Relevance 0.08
In contrast, there were no significant changes in the levels of HSP60 or BiP after therapy.
Neg (no) Regulation (changes) of BiP
8) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.82 Pain Relevance 0.37

General Comments

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