INT92316

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 22.06
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Plaur) plasma membrane (Plaur) enzyme binding (Plaur)
kinase activity (Plaur)
Anatomy Link Frequency
epithelial cells 3
IEC-6 1
brain 1
HGF 1
MDA-MB-231 1
Plaur (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 15 98.66 Very High Very High Very High
metalloproteinase 44 97.56 Very High Very High Very High
Inflammation 287 97.40 Very High Very High Very High
Dismenorea 3 97.32 Very High Very High Very High
cytokine 90 87.56 High High
interstitial cystitis 1 84.00 Quite High
Angina 1 80.52 Quite High
chemokine 20 69.68 Quite High
imagery 31 50.72 Quite High
Kinase C 21 48.88 Quite Low
Disease Link Frequency Relevance Heat
Glioma 554 99.84 Very High Very High Very High
Cancer 1302 99.80 Very High Very High Very High
Brain Tumor 16 99.32 Very High Very High Very High
Anaplastic Astrocytoma 14 99.32 Very High Very High Very High
Adhesions 267 99.20 Very High Very High Very High
Cytomegalovirus Infection 18 98.72 Very High Very High Very High
Myocardial Infarction 9 98.72 Very High Very High Very High
Glioblastoma 266 98.52 Very High Very High Very High
INFLAMMATION 321 98.48 Very High Very High Very High
Breast Cancer 13 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of urokinase-type plasminogen activator receptor (uPAR) is much more robust in high-grade than in low-grade human gliomas [18].
Gene_expression (Expression) of urokinase-type plasminogen activator receptor associated with glioma
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 1.16 Pain Relevance 0.17
Expression of urokinase-type plasminogen activator receptor (uPAR) is much more robust in high-grade than in low-grade human gliomas [18].
Gene_expression (Expression) of uPAR associated with glioma
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 1.16 Pain Relevance 0.17
When respective stromal cells were cocultured, the heterotopic epithelial cells exhibited significantly higher invasive ability through Matrigel than did the eutopic epithelial cells. uPAR overexpression in the epithelial cells and high secretion of uPA from the stromal cells may contribute to the invasive phenotype of heterotopic endometrium.
Gene_expression (overexpression) of uPAR in epithelial cells
3) Confidence 0.58 Published 2000 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 11093058 Disease Relevance 0.26 Pain Relevance 0.08
This study was undertaken to characterize the expression of both uPA and its receptor (uPAR) in the eutopic and heterotopic endometrial cells from women with adenomyosis by testing both types of epithelial cells for invasive ability.
Gene_expression (expression) of uPAR in epithelial cells associated with dismenorea
4) Confidence 0.58 Published 2000 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 11093058 Disease Relevance 0.37 Pain Relevance 0.10
The heterotopic epithelial cells overexpressed uPAR by a factor of four times the expression seen in the eutopic epithelial cells.
Gene_expression (overexpressed) of uPAR in epithelial cells
5) Confidence 0.58 Published 2000 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 11093058 Disease Relevance 0.31 Pain Relevance 0.09
Xenografts were transfected with SV-sh (scrambled vector), M-sh (MMP-9), U-sh (uPAR), C-sh (cathepsin B), MU-sh (MMP-9 and uPAR) or MC-sh (MMP-9 and cathepsin B) shRNA expressing plasmids using Fugene® HD reagent (Roche Diagnostics, Indianapolis, IN) as per the manufacturer's instructions.
Gene_expression (expressing) of uPAR
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.30 Pain Relevance 0
Localization of uPAR mRNA in astrocytoma cells and the endothelial cells within brain tumor tissue has been reported and the expression of uPAR in the invading astrocytoma cells appears to have a critical role in the invasive behavior of glioblastoma [18].
Gene_expression (expression) of uPAR in endothelial cells associated with anaplastic astrocytoma, glioblastoma and brain tumor
7) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.98 Pain Relevance 0.15
MMP-9 expressing (M-fl) plasmids in pDNR-CMV vector were designed and constructed in our laboratory whereas uPAR expressing (U-fl) and cathepsin B expressing (C-fl) plasmids were purchased from Origene (Rockville, MD).


Gene_expression (expressing) of uPAR associated with cytomegalovirus infection
8) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.27 Pain Relevance 0
1 and uPAR/?
Gene_expression (/) of uPAR
9) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 1.06 Pain Relevance 0
Our results indicated that several genes known to be part of the inflammatory response were found downstream of PAR1 activation (b2m, ccl7, cd200, cd63, cdbpd, cfl1, dusp1, fkbp1a, fth1, hspb1, marcksl1, mmp2, myo5a, nfkbia, pax1, plaur, ppia, ptpn1, ptprcap, s100a10, sim2, and tnfaip2).
Gene_expression (cdbpd) of plaur associated with inflammatory response
10) Confidence 0.44 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.88 Pain Relevance 0.35
Cathepsin B and urokinase-type plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas and, as such, are attractive targets for gene therapy.
Gene_expression (overexpressed) of uPAR associated with glioma
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.84 Pain Relevance 0
In contrast, uPAR overexpression inhibited cell growth in murine embryonic fibroblast cells and induced cell growth in keratinocytes [68]. uPAR has been detected as a potential cooperating oncogene in Ink4a KO mice, which are deficient in cell growth control [69].
Gene_expression (overexpression) of uPAR in keratinocytes
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.89 Pain Relevance 0
Our previous work and that of others strongly suggest a relationship between the infiltrative phenotype of glioma and the expression of cathepsin B and uPAR.
Gene_expression (expression) of uPAR associated with glioma
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 1.04 Pain Relevance 0
Immunohistochemical analysis of the tumor sections from control mice for cathepsin B and uPAR showed increased expression levels localized to the tumor region while the pCU-treated tumor sections revealed very little or no expression of the cathepsin B and uPAR.
Neg (no) Gene_expression (expression) of uPAR associated with cancer
14) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.69 Pain Relevance 0
Cathepsin B and urokinase-type plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas and, as such, are attractive targets for gene therapy.
Gene_expression (overexpressed) of urokinase-type plasminogen activator receptor associated with glioma
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.84 Pain Relevance 0
Similarly, uPAR expression was reduced by 75–80% in both cell lines when treated with pU.
Gene_expression (expression) of uPAR
16) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.08 Pain Relevance 0
Our previous work and that of others strongly suggest a relationship between the infiltrative phenotype of glioma and the expression of cathepsin B and uPAR.
Gene_expression (expression) of uPAR associated with glioma
17) Confidence 0.32 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.44 Pain Relevance 0
Various reports have demonstrated that cathepsin B and uPAR levels are overexpressed during glioma progression [28]–[30].
Gene_expression (overexpressed) of uPAR associated with glioma
18) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.78 Pain Relevance 0
Cells treated with pC did not show any difference in expression when compared to controls (95±3%). uPAR expression in pCU-treated cells was significantly reduced by 80–91% (Fig. 1A) (p<0.01).
Gene_expression (expression) of uPAR
19) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0
The expression of p27Kip1 and FOXO3a proteins were also assessed in cathepsin B and uPAR-overexpressing cells, and we found a correlation with the above mentioned results (Fig.
Gene_expression (overexpressing) of uPAR
20) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0

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