INT92317

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.84
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Plaur) plasma membrane (Plaur) enzyme binding (Plaur)
kinase activity (Plaur)
Anatomy Link Frequency
epithelial cells 4
keratinocytes 2
MDA-MB-231 2
Plaur (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 7 97.44 Very High Very High Very High
Dismenorea 2 88.24 High High
Inflammation 116 69.96 Quite High
cytokine 33 68.08 Quite High
Kinase C 4 49.24 Quite Low
chemokine 10 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 106 99.84 Very High Very High Very High
Breast Cancer 6 98.42 Very High Very High Very High
Cancer 322 96.00 Very High Very High Very High
Colon Cancer 61 95.72 Very High Very High Very High
Endometriosis 4 88.24 High High
Skin Cancer 6 88.20 High High
Metastasis 27 87.32 High High
Lung Cancer 6 78.12 Quite High
Adhesions 13 74.04 Quite High
INFLAMMATION 124 69.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The heterotopic epithelial cells overexpressed uPAR by a factor of four times the expression seen in the eutopic epithelial cells.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of uPAR in epithelial cells
1) Confidence 0.52 Published 2000 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 11093058 Disease Relevance 0.31 Pain Relevance 0.09
When respective stromal cells were cocultured, the heterotopic epithelial cells exhibited significantly higher invasive ability through Matrigel than did the eutopic epithelial cells. uPAR overexpression in the epithelial cells and high secretion of uPA from the stromal cells may contribute to the invasive phenotype of heterotopic endometrium.
Positive_regulation (overexpression) of Gene_expression (overexpression) of uPAR in epithelial cells
2) Confidence 0.37 Published 2000 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 11093058 Disease Relevance 0.26 Pain Relevance 0.08
In contrast, uPAR overexpression inhibited cell growth in murine embryonic fibroblast cells and induced cell growth in keratinocytes [68]. uPAR has been detected as a potential cooperating oncogene in Ink4a KO mice, which are deficient in cell growth control [69].
Positive_regulation (overexpression) of Gene_expression (overexpression) of uPAR in keratinocytes
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.89 Pain Relevance 0
Cathepsin B and urokinase-type plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas and, as such, are attractive targets for gene therapy.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of uPAR associated with glioma
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.84 Pain Relevance 0
Various reports have demonstrated that cathepsin B and uPAR levels are overexpressed during glioma progression [28]–[30].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of uPAR associated with glioma
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.78 Pain Relevance 0
Cathepsin B and urokinase-type plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas and, as such, are attractive targets for gene therapy.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of urokinase-type plasminogen activator receptor associated with glioma
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.84 Pain Relevance 0
Loss of TTP is observed in the highly metastatic breast tumor line, MDA-MB-231, that is functionally associated with increased invasion and elevated expression of uPA and uPAR mRNAs due to their stabilization [162].
Positive_regulation (elevated) of Gene_expression (expression) of uPAR in MDA-MB-231 associated with breast cancer
7) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.84 Pain Relevance 0.13
Quantitative PCR analysis confirmed that constitutive activation of MEK1 or MEK2 induces the expression of urokinase receptor mRNA (Fig. 4B).
Positive_regulation (induces) of Gene_expression (expression) of urokinase receptor mRNA
8) Confidence 0.02 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.07 Pain Relevance 0.18

General Comments

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