INT9233

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 2010
Negated 8
Speculated 1
Reported most in Abstract
Documents 114
Total Number 115
Disease Relevance 56.99
Pain Relevance 41.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
monocytes 20
macrophages 9
cartilage 9
chondrocytes 6
articular cartilage 6
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 878 100.00 Very High Very High Very High
Inflammation 876 100.00 Very High Very High Very High
rheumatoid arthritis 721 100.00 Very High Very High Very High
Arthritis 410 100.00 Very High Very High Very High
metalloproteinase 163 100.00 Very High Very High Very High
Inflammatory mediators 66 100.00 Very High Very High Very High
substance P 35 100.00 Very High Very High Very High
IPN 27 100.00 Very High Very High Very High
Hyperalgesia 11 100.00 Very High Very High Very High
mu opioid receptor 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1021 100.00 Very High Very High Very High
Rheumatoid Arthritis 837 100.00 Very High Very High Very High
Arthritis 361 100.00 Very High Very High Very High
Hyperalgesia 17 100.00 Very High Very High Very High
Brain Injury 13 100.00 Very High Very High Very High
Cancer 116 99.88 Very High Very High Very High
Temporomandibular Joint Syndrome 23 99.80 Very High Very High Very High
Necrosis 84 99.60 Very High Very High Very High
Neuropathic Pain 9 99.58 Very High Very High Very High
Osteoarthritis 958 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone (10-100 nM) inhibited IL-1 production and IL-1 mediated thymocyte proliferation.
Negative_regulation (inhibited) of Gene_expression (production) of IL-1 in thymocyte associated with dexamethasone
1) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.38
Gold compounds inhibited IL-1 activity, but only auranofin inhibited IL-1 production.
Negative_regulation (inhibited) of Gene_expression (production) of IL-1
2) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.22 Pain Relevance 0.39
D-penicillamine inhibited IL-1 activity and tended to inhibit IL-1 production.
Negative_regulation (inhibit) of Gene_expression (production) of IL-1
3) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.23 Pain Relevance 0.39
Colchicine inhibited IL-1 activity but not IL-1 production.
Negative_regulation (inhibited) of Gene_expression (production) of IL-1
4) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.20 Pain Relevance 0.36
Acetaminophen in high concentrations (1 mg/ml) inhibited IL-1 activity and production.
Negative_regulation (inhibited) of Gene_expression (production) of IL-1 associated with paracetamol
5) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.21 Pain Relevance 0.37
A high capacity screening assay for the detection of inhibitors of IL-1 biosynthesis has been established.
Negative_regulation (inhibitors) of Gene_expression (biosynthesis) of IL-1
6) Confidence 0.58 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.20 Pain Relevance 0.08
The steroids prednisolone and dexamethasone, gold (sodium aurothiomalate) and chloroquine were potent inhibitors of the IL-1 production.
Negative_regulation (inhibitors) of Gene_expression (production) of IL-1 associated with dexamethasone
7) Confidence 0.58 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.22 Pain Relevance 0.16
Inhibition of IL-1 beta production from ATP-treated monocytes and macrophages.
Negative_regulation (Inhibition) of Gene_expression (production) of IL-1 in macrophages
8) Confidence 0.58 Published 1994 Journal J. Immunol. Section Title Doc Link 8051418 Disease Relevance 0.25 Pain Relevance 0.22
In the absence of LPS and at therapeutic concentration, tiaprofenic acid decreased both the synthesis and release of IL-1 beta.
Negative_regulation (decreased) of Gene_expression (synthesis) of IL-1 beta
9) Confidence 0.58 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8456629 Disease Relevance 0.34 Pain Relevance 0.50
Moreover, LPS-activated monocytes that were pretreated with granulocyte-macrophage colony-stimulating factor were less sensitive to the proIL-1 beta inhibitory effect of SKF86002, and production of proIL-1 beta by cytokine-stimulated human fibroblasts was impaired only modestly by the CSAID.
Negative_regulation (impaired) of Gene_expression (production) of proIL-1 beta in monocytes associated with cytokine
10) Confidence 0.57 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7565623 Disease Relevance 0.16 Pain Relevance 0.23
Inhibition of IL-1 beta production was achieved by affecting two separate steps in this cytokine's biogenesis.
Negative_regulation (Inhibition) of Gene_expression (production) of IL-1 associated with cytokine
11) Confidence 0.57 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7565623 Disease Relevance 0.32 Pain Relevance 0.27
This drug significantly reduced the levels of TNF-alpha and IL-1beta only on day 7.
Negative_regulation (reduced) of Gene_expression (levels) of IL-1beta
12) Confidence 0.57 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17664076 Disease Relevance 0.94 Pain Relevance 0.88
IL-10 is very interesting since it reduces allodynia and hyperalgesia by suppressing the production and activity of TNF-alpha, IL-1beta and IL-6.
Negative_regulation (suppressing) of Gene_expression (production) of IL-1beta associated with hyperalgesia and allodynia
13) Confidence 0.57 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 18622054 Disease Relevance 0.92 Pain Relevance 1.62
We conclude that brief ischemia of remote preconditioning such as heart or liver protects gastric mucosa against severe ischemia-reperfusion-induced gastric lesions as effectively as local preconditioning of the stomach itself via the mechanism involving prostaglandin derived from cyclooxygenase-1 and cyclooxygenase-2 and the activation of sensory nerves releasing calcitonin gene-related peptide (CGRP) combined with the suppression of interleukin-1beta and TNF-alpha expression and release.
Negative_regulation (suppression) of Gene_expression (expression) of interleukin-1beta in stomach associated with ischemia and calcitonin gene-related peptide
14) Confidence 0.57 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363968 Disease Relevance 0.64 Pain Relevance 0.35
However, silica-ceramic suppressed the synthesis of cytokines involved in inflammation, in particular, the expression of IL-1beta and IL-6 was reduced at the transcriptional and translational levels.
Negative_regulation (suppressed) of Gene_expression (expression) of IL-1beta associated with inflammation and cytokine
15) Confidence 0.57 Published 2007 Journal Journal of biomedical materials research. Part A Section Abstract Doc Link 17133451 Disease Relevance 0.27 Pain Relevance 0.63
Piroxicam has been shown to downregulate the expression of interleukin 1 (IL-1) associated chondrocyte enzyme inducing activity (catabolin) produced by OA synovium.
Negative_regulation (downregulate) of Gene_expression (expression) of interleukin 1 in synovium associated with osteoarthritis
16) Confidence 0.51 Published 1991 Journal J Rheumatol Suppl Section Abstract Doc Link 2027111 Disease Relevance 0.46 Pain Relevance 0.31
CONCLUSIONS: The results suggest that interleukin-1 beta may be involved in the pathogenesis of temporomandibular joint internal derangement and that the intensity of interleukin-1 beta expression may correlate with clinical findings, especially pain.


Negative_regulation (intensity) of Gene_expression (expression) of interleukin-1 beta in temporomandibular joint
17) Confidence 0.43 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 10519747 Disease Relevance 0.13 Pain Relevance 0
Gold compounds inhibited IL-1 activity, but only auranofin inhibited IL-1 production.
Negative_regulation (inhibited) of Gene_expression (production) of IL-1
18) Confidence 0.43 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.22 Pain Relevance 0.39
The objective of our study was to investigate the effect of a number of representative antirheumatic agents on the activity of IL-1 and the production of both IL-1 and IL-1 inhibitor by human monocytes.
Negative_regulation (inhibitor) of Gene_expression (production) of IL-1 in monocytes
19) Confidence 0.43 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.27
High concentrations of indomethacin, aspirin, and 12 other nonsteroidal antiinflammatory drugs (NSAID) inhibited IL-1 activity, or production or both.
Negative_regulation (inhibited) of Gene_expression (production) of IL-1 associated with aspirin, inflammation and cinod
20) Confidence 0.43 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.25 Pain Relevance 0.40

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