INT92330

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 13.12
Pain Relevance 5.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
adipose tissue 5
platelet 4
plasma 2
cartridge 1
erythrocytes 1
WDTC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 36 99.56 Very High Very High Very High
aspirin 759 99.52 Very High Very High Very High
Inflammation 114 99.24 Very High Very High Very High
Angina 47 88.88 High High
cINOD 11 84.56 Quite High
antagonist 60 83.84 Quite High
cytokine 18 78.84 Quite High
agonist 35 78.72 Quite High
adenocard 107 77.72 Quite High
cva 9 73.08 Quite High
Disease Link Frequency Relevance Heat
Obesity 346 100.00 Very High Very High Very High
Coronary Artery Disease 27 99.56 Very High Very High Very High
Acute Coronary Syndrome 65 99.28 Very High Very High Very High
INFLAMMATION 133 99.24 Very High Very High Very High
Diabetes Mellitus 128 98.54 Very High Very High Very High
Insulin Resistance 16 98.40 Very High Very High Very High
Arrhythmia Under Development 6 98.40 Very High Very High Very High
Myocardial Infarction 137 97.08 Very High Very High Very High
Heart Disease 171 95.72 Very High Very High Very High
Angina 45 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ADP-collagen cartridge (ADP-COLL) is only weakly sensitive to aspirin.
Gene_expression (cartridge) of ADP in cartridge associated with aspirin
1) Confidence 0.47 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.07 Pain Relevance 0.22
Plasma levels of ADP were markedly increased in STEMI (905 ± 721 nmol/l, p < 0.01), but not in NSTEMI (317 ± 245), compared to NCD (334 ± 271, mean ± SD) (Fig 3).
Gene_expression (levels) of ADP in Plasma associated with heart disease
2) Confidence 0.47 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.69 Pain Relevance 0.24
Why did the patients with aspirin resistance have higher ADP levels?
Gene_expression (levels) of ADP associated with aspirin
3) Confidence 0.47 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.74 Pain Relevance 0.47
However, ADP levels did not correlate with either CKMB or troponin T levels.
Gene_expression (levels) of ADP
4) Confidence 0.47 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.71 Pain Relevance 0.44
Thus, high levels of ADP could replace thromboxane as stimulator of IP3 by activation of P2Y1 receptors.
Gene_expression (levels) of ADP
5) Confidence 0.47 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.45 Pain Relevance 0.40
We wanted to evaluate the effect of aspirin on platelet function in patients with acute coronary syndromes and we hypothesized that increased levels of ADP in patients with acute coronary syndromes could contribute to aspirin resistance.


Gene_expression (levels) of ADP in platelet associated with aspirin and acute coronary syndrome
6) Confidence 0.42 Published 2005 Journal Thromb J Section Abstract Doc Link PMC1192820 Disease Relevance 0.67 Pain Relevance 0.39
Increased levels of ADP could be one reason for increased platelet activity and aspirin resistance.


Gene_expression (levels) of ADP in platelet associated with aspirin
7) Confidence 0.42 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0 Pain Relevance 0.25
Increased levels of ADP could be one reason for increased platelet activity and aspirin resistance.



Gene_expression (levels) of ADP in platelet associated with aspirin
8) Confidence 0.42 Published 2005 Journal Thromb J Section Abstract Doc Link PMC1192820 Disease Relevance 0.59 Pain Relevance 0.41
Furthermore, we hypothesized that increased levels of ADP in patients with acute coronary syndromes could contribute to aspirin resistance.


Gene_expression (levels) of ADP associated with aspirin and acute coronary syndrome
9) Confidence 0.42 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.76 Pain Relevance 0.69
Among the known genes differentially expressed in HT-29 cells after sulindac treatment were those encoding acetylglucosaminyltransferase, ferritin heavy chain, zinc finger protein 165, aldose reductase, carcinoembryonic antigen, aldoketoreductase, NF-kappaB-activating kinase, lysosome-associated protein, RhoE = 26 kDa GTPase homologue, NADH oxidoreductase, G/T mismatch bindingprotein, TM7SF3, ADP/ATP carrier-like protein and chromosome segregation protein.
Gene_expression (expressed) of ADP in finger
10) Confidence 0.26 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 11093808 Disease Relevance 0.47 Pain Relevance 0.51
Measurements of adipose blood flow in rats using microspheres find about a 5 fold perfusion range for different fat depots [45].
Gene_expression (blood) of adipose in fat
11) Confidence 0.06 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0.14 Pain Relevance 0
It is assumed in the PKQuest PBPK model that the exchange between adipose tissue and blood is flow (perfusion) rate limited.
Gene_expression (tissue) of adipose in blood associated with obesity
12) Confidence 0.06 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0.17 Pain Relevance 0
The heterogeneous perfusion of human adipose tissue can only be resolved by following the blood concentrations for long times (2 days or more).
Gene_expression (tissue) of adipose in adipose tissue associated with obesity
13) Confidence 0.06 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0.17 Pain Relevance 0
Flow limited versus diffusion limited adipose models
Gene_expression (models) of adipose
14) Confidence 0.06 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0.17 Pain Relevance 0
Two ADP receptors (P2Y12 and P2Y1) and one ion channel ATP receptor (P2X1) are expressed on platelets [197, 198] (Fig. 4).
Gene_expression (expressed) of ADP in platelets
15) Confidence 0.04 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.49 Pain Relevance 0.06
ADP, released from erythrocytes or produced after ectonucleotidase breakdown of ATP released from erythrocytes and endothelial cells, was found to cause platelet aggregation as early as 1961, before the concept of P2 receptors was conceived [193].
Gene_expression (produced) of ADP in erythrocytes
16) Confidence 0.03 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.57 Pain Relevance 0.13
Multiple regression analysis (PROC REG) was performed to identify whether the level of BMI, parameters of inflammation, and type 2 diabetes (explanatory variable) could explain the variation in plasma YKL-40 and adipose tissue YKL-40 mRNA expression (dependent variable).
Gene_expression (expression) of adipose in adipose tissue associated with inflammation, diabetes mellitus and obesity
17) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.58 Pain Relevance 0.07
No association was found between adipose tissue YKL-40 mRNA expression and parameters of inflammation or parameters of obesity.


Gene_expression (expression) of adipose in adipose tissue associated with inflammation and obesity
18) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.81 Pain Relevance 0.08
In the present study, using plasma and adipose tissue biopsy material from 103 healthy control subjects and 96 patients with type 2 diabetes with a wide range of BMI, we studied the possible relationship between plasma YKL-40 and adipose tissue expression of YKL-40 on the one hand and obesity, insulin resistance, and inflammation on the other.
Gene_expression (expression) of adipose in adipose tissue associated with inflammation, diabetes mellitus, obesity and insulin resistance
19) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 2.26 Pain Relevance 0.34
It is assumed in the PKQuest PBPK model that the exchange between adipose tissue and blood is flow (perfusion) rate limited.
Gene_expression (tissue) of adipose in adipose tissue associated with obesity
20) Confidence 0.02 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1797001 Disease Relevance 0.17 Pain Relevance 0

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