INT92331

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.99
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
finger 1
bladder 1
kupffer cells 1
ATP8A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 100.00 Very High Very High Very High
cINOD 7 84.56 Quite High
Paracetamol 5 75.00 Quite High
Dismenorea 2 70.40 Quite High
c fibre 2 66.00 Quite High
Inflammatory response 1 65.36 Quite High
potassium channel 66 64.56 Quite High
aspirin 2 62.36 Quite High
Inflammation 8 62.20 Quite High
antagonist 11 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 117 99.04 Very High Very High Very High
Shock 1 96.60 Very High Very High Very High
Necrosis 1 91.76 High High
Hypoalbuminemia 8 91.68 High High
Parkinson's Disease 3 90.56 High High
Disease 9 87.44 High High
Apoptosis 1 83.40 Quite High
Overactive Bladder 4 79.12 Quite High
Toxicity 2 77.88 Quite High
INFLAMMATION 11 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: The ATP-gated purinergic receptor P2X3 is expressed by small diameter sensory neurons and has been identified in normal and neurogenic human bladder suburothelial fibres.
Gene_expression (expressed) of ATP in bladder
1) Confidence 0.75 Published 2004 Journal Eur. Urol. Section Abstract Doc Link 15245821 Disease Relevance 0.28 Pain Relevance 0.13
Among the known genes differentially expressed in HT-29 cells after sulindac treatment were those encoding acetylglucosaminyltransferase, ferritin heavy chain, zinc finger protein 165, aldose reductase, carcinoembryonic antigen, aldoketoreductase, NF-kappaB-activating kinase, lysosome-associated protein, RhoE = 26 kDa GTPase homologue, NADH oxidoreductase, G/T mismatch bindingprotein, TM7SF3, ADP/ATP carrier-like protein and chromosome segregation protein.
Gene_expression (expressed) of ATP in finger
2) Confidence 0.58 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 11093808 Disease Relevance 0.47 Pain Relevance 0.51
In addition to the diminishing capacity to synthesize ATP, endonuclease G and AIF are further released.
Gene_expression (synthesize) of ATP
3) Confidence 0.58 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16177235 Disease Relevance 0.79 Pain Relevance 0.26
In Figures 7, the mean effect of cumulative additions of THG113.31 on spontaneous (n = 6) contractions of myometrial strips, in the presence and absence of IbTX, are shown in graphical form alongside the integrals observed in control strips.


Neg (absence) Gene_expression (absence) of IbTX
4) Confidence 0.04 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1831777 Disease Relevance 0.07 Pain Relevance 0.13
Comparison of the inhibitory effects of THG113.31 on spontaneous contractions of myometrial strips, in the presence or absence of IbTX, revealed a significant difference across the groups (Group 2 versus Group 4; n = 6; P <0.05).
Neg (absence) Gene_expression (absence) of IbTX
5) Confidence 0.04 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1831777 Disease Relevance 0 Pain Relevance 0
Presence of micrometastatic tumor cells in liver may induce the kupffer cells to produce a variety of cytokines (IL-Ib, IL-6 ve TNF), which may modulate albumin synthesis by hepatocytes [33,34].
Gene_expression (produce) of IL-Ib in kupffer cells associated with cancer and cytokine
6) Confidence 0.03 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.38 Pain Relevance 0.19

General Comments

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