INT92335

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Context Info
Confidence 0.28
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 8.98
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TBK1) plasma membrane (TBK1) cytoplasm (TBK1)
Anatomy Link Frequency
finger 1
mononuclear cells 1
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 530 100.00 Very High Very High Very High
cytokine 120 99.80 Very High Very High Very High
cINOD 84 95.20 Very High Very High Very High
Pain 44 89.76 High High
aspirin 20 87.28 High High
addiction 2 85.60 High High
cva 6 78.60 Quite High
tolerance 6 75.92 Quite High
metalloproteinase 14 72.40 Quite High
corticosteroid 58 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 695 100.00 Very High Very High Very High
Targeted Disruption 10 98.96 Very High Very High Very High
Cancer 252 98.28 Very High Very High Very High
Disease 213 98.24 Very High Very High Very High
Adhesions 19 97.96 Very High Very High Very High
Apoptosis 22 96.44 Very High Very High Very High
Adenocarcinoma 52 95.28 Very High Very High Very High
Esophageal Cancer 34 93.44 High High
Diabetes Mellitus 34 91.56 High High
Sprains And Strains 34 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, some amplified genes (MEMO1, IGFP6, TBK1, MIB1, RIOK3), determined by the DNA chip array demonstrated high level of RNA overexpression as well.


Gene_expression (overexpression) of TBK1
1) Confidence 0.28 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.66 Pain Relevance 0
Thus, the overexpression of the MEMO1 and the TBK1 genes in PaCa 5061 cells could be associated with the high tumorigenic and metastatic nature of these cells.
Gene_expression (overexpression) of TBK1
2) Confidence 0.25 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.54 Pain Relevance 0
Activation was not TBK1 or PKC dependent, however, suggesting alternative activation compared to previously described mechanisms of IRF3 activation [50].
Neg (not) Gene_expression (dependent) of TBK1
3) Confidence 0.18 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.55 Pain Relevance 0
IRF3-P responses to r-ceramide were reduced by the TLR4 and TRAM siRNAs but were less affected by suppression of TBK1 expression.
Gene_expression (expression) of TBK1
4) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.09 Pain Relevance 0.04
Based on the premise that IkBa forms a complex with the available cytoplasmic NF-kB mathematically we expressed is as the product (1-NFkBn) IkBa.
Gene_expression (expressed) of NF-kB
5) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.07 Pain Relevance 0.03
In the inflammatory gene network shown in Fig. 3(A), genes such as NF-kB, TNF-?
Gene_expression (genes) of NF-kB associated with inflammation
6) Confidence 0.08 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.55 Pain Relevance 0.23
Immunosuppressant drugs also reduce nuclear expression of NF-kB.[397075] Research now indicates that blocking the activation of NF-kB along with other inflammation mediators [Table 2] is the major mechanism for reducing inflammation by natural compounds.


Gene_expression (expression) of NF-kB associated with inflammation
7) Confidence 0.08 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.81 Pain Relevance 0.62
More recently Izzo et al., found that activated NF-KB expression was significantly associated with residual disease following neo-adjuvant CRT (p = 0.006), metastatic progression (p = 0.01) and reduced survival (p = 0.01) in 80 oesophageal cancer patients [58].



Gene_expression (expression) of NF-KB associated with esophageal cancer and disease
8) Confidence 0.08 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1999497 Disease Relevance 0.97 Pain Relevance 0.04
NF-kB inflammatory pathways and cytokines
Gene_expression (pathways) of NF-kB associated with inflammation and cytokine
9) Confidence 0.06 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 1.20 Pain Relevance 0.83
In fact, insulin reduces ROS generation by mononuclear cells, suppresses NADPH oxidase expression and intranuclear NF-kB binding, induces IkB expression and suppresses some inflammatory molecules [69,76].
Gene_expression (expression) of NF-kB in mononuclear cells associated with inflammation
10) Confidence 0.05 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.76 Pain Relevance 0.33
2) High constitutive hyper-expression of NF-kB, an ubiquitous transcription factor with regulatory effect upon different inflammatory, apoptotic and oncogenic genes [82].
Gene_expression (expression) of NF-kB associated with inflammation and apoptosis
11) Confidence 0.04 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.31 Pain Relevance 0.38
Among the known genes differentially expressed in HT-29 cells after sulindac treatment were those encoding acetylglucosaminyltransferase, ferritin heavy chain, zinc finger protein 165, aldose reductase, carcinoembryonic antigen, aldoketoreductase, NF-kappaB-activating kinase, lysosome-associated protein, RhoE = 26 kDa GTPase homologue, NADH oxidoreductase, G/T mismatch bindingprotein, TM7SF3, ADP/ATP carrier-like protein and chromosome segregation protein.
Gene_expression (expressed) of NF-kappaB-activating kinase in finger
12) Confidence 0.03 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 11093808 Disease Relevance 0.46 Pain Relevance 0.49

General Comments

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