INT92343

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 6.25
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CENPJ) cytoskeleton (CENPJ) cell division (CENPJ)
cytoplasm (CENPJ)
Anatomy Link Frequency
lung 4
respiratory 3
plasma 1
blood 1
Nasal 1
CENPJ (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 5 69.20 Quite High
ischemia 4 64.88 Quite High
Angina 2 55.84 Quite High
depression 36 50.40 Quite High
anesthesia 17 50.32 Quite High
Serotonin 27 50.00 Quite Low
halothane 1 49.32 Quite Low
alcohol 23 29.88 Quite Low
sSRI 18 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bronchospasm 153 99.42 Very High Very High Very High
Obstructive Sleep Apnea 489 98.90 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 88 98.60 Very High Very High Very High
Barotrauma 8 98.48 Very High Very High Very High
Apnoea 72 98.24 Very High Very High Very High
Pressure Volume 2 Under Development 3 97.32 Very High Very High Very High
Weight Gain 3 96.88 Very High Very High Very High
Hypertension 25 95.80 Very High Very High Very High
Weight Loss 18 93.60 High High
Heart Rate Under Development 12 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding that WOB decreases with CPAP in all groups except for the ETT group suggests that the decrease is a result of improved patency of the upper airway rather than of increases in functional residual capacity and lung compliance.
Negative_regulation (decreases) of CPAP in upper
1) Confidence 0.57 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 11093984 Disease Relevance 0 Pain Relevance 0.05
The only significant hemodynamic change was a decrease in mean arterial pressure during CPAP in non-responders from 86 ± 12 to 70 ± 16 mm Hg (P = 0.0081); the decrease in blood pressure during eSigh was not significant.
Negative_regulation (decrease) of CPAP in blood associated with pressure volume 2 under development
2) Confidence 0.30 Published 2008 Journal Crit Care Section Body Doc Link PMC2447604 Disease Relevance 0.21 Pain Relevance 0
7), and 33.3% patients had remission on SASS (?
Negative_regulation (remission) of SASS
3) Confidence 0.27 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2951748 Disease Relevance 0.16 Pain Relevance 0.03
CPAP leads to reductions in plasma norepinephrine levels by both increases in norepinephrine clearance and decreases in diurnal and nocturnal excretion compared with sham CPAP or oxygen supplementation alone (Mills et al 2006).
Negative_regulation (decreases) of CPAP in plasma
4) Confidence 0.26 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.46 Pain Relevance 0
Surgical intervention by tracheostomy was the first effect treatment of OSA but the role of surgery in this condition has greatly diminished with the development of more acceptable or effective treatments, in particular CPAP.
Negative_regulation (diminished) of CPAP associated with obstructive sleep apnea
5) Confidence 0.23 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.57 Pain Relevance 0.03
Continuous positive airway pressure (CPAP)
Negative_regulation (pressure) of CPAP
6) Confidence 0.22 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.09 Pain Relevance 0
Alternatively, CPAP has been shown to hyperinflate preferentially the rib cage compartment over the abdominal compartment in patients with COPD and acute histamine-induced bronchospasm [5,22], which may limit the CPAP-induced reduction in Ppl workload.
Negative_regulation (reduction) of CPAP-induced in rib associated with bronchospasm and chronic obstructive pulmonary disease
7) Confidence 0.10 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.25 Pain Relevance 0
Although both Ppl and Pdi indices of inspiratory work decreased after IPAP and CPAP, only the reduction in Pdi work achieved statistical significance.
Negative_regulation (decreased) of CPAP
8) Confidence 0.08 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0 Pain Relevance 0
c) Nasal continuous positive airway pressure (CPAP)
Negative_regulation (pressure) of CPAP in Nasal
9) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1373626 Disease Relevance 0.85 Pain Relevance 0.06
Other studies have similarly shown a significant reduction in tidal Pdi swings but not esophageal pressure swings with CPAP in patients with airflow limitation [6,10].
Negative_regulation (reduction) of CPAP
10) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.11 Pain Relevance 0
Thus, it does not appear that the CPAP reduction in the inspiratory work of breathing was due to changes in expiratory flow resistance.


Negative_regulation (reduction) of CPAP
11) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.24 Pain Relevance 0
This CPAP-induced paradoxic decrease in inspiratory work of breathing and increase in lung volume has made it difficult to define the 'optimal' CPAP levels for ventilatory support in airflow limitation.
Negative_regulation (decrease) of CPAP-induced in lung
12) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.17 Pain Relevance 0
This could not be explained by an increase in EELV alone because a similar amount of hyperinflation occurred with CPAP but CPAP reduced respiratory work.
Negative_regulation (reduced) of CPAP in respiratory
13) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.43 Pain Relevance 0
This could not be explained by an increase in EELV alone because a similar amount of hyperinflation occurred with CPAP but CPAP reduced respiratory work.
Negative_regulation (reduced) of CPAP in respiratory
14) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.43 Pain Relevance 0
This CPAP-induced paradoxic decrease in inspiratory work of breathing and increase in lung volume has made it difficult to define the 'optimal' CPAP levels for ventilatory support in airflow limitation.
Negative_regulation (define) of CPAP in lung
15) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.16 Pain Relevance 0
They showed that the RSBI significantly decreased during a trial of pressure support ventilation, during a continuous positive airway pressure (CPAP) trial on 40% oxygen, and during a CPAP trial on room air as compared to a trial of 1 minute spontaneously breathing room air and off the ventilator.
Negative_regulation (decreased) of CPAP
16) Confidence 0.04 Published 2008 Journal Crit Care Section Body Doc Link PMC2575571 Disease Relevance 0.18 Pain Relevance 0
The over-all effects of lung lavage was a reduction in PaO2 both during PAV and during CPAP as compared to the pre-lavage values, with a concomitant increase in inspired fraction of oxygen from 0.21 to 0.76 (Table 1).
Negative_regulation (reduction) of CPAP in lung
17) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1420291 Disease Relevance 0 Pain Relevance 0
After instillation of surfactant, the oxygenation increased and the transpulmonary pressure decreased both during CPAP and PAV, showing an improved gas exchange after surfactant instillation, as reported by other authors [29-32].
Negative_regulation (decreased) of CPAP
18) Confidence 0.03 Published 2006 Journal Respir Res Section Body Doc Link PMC1420291 Disease Relevance 0.14 Pain Relevance 0
The decrease in PNA amplitude and duration during PAV, occurring concomitantly with the decrease in esophageal pressure and the increase in tidal volume, was immediate when CPAP was switched to PAV, as observed in a recording made after lung lavage (Fig. 2).


Negative_regulation (switched) of CPAP in lung
19) Confidence 0.03 Published 2006 Journal Respir Res Section Body Doc Link PMC1420291 Disease Relevance 0 Pain Relevance 0
However, with mechanical ventilation with PEEP, ITP is increased throughout all phases of the respiratory cycle, while with CPAP, ITP is increased at end-expiration, but decreases during inspiration.
Negative_regulation (decreases) of CPAP in respiratory
20) Confidence 0.01 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.82 Pain Relevance 0.03

General Comments

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