INT92354

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 77
Total Number 81
Disease Relevance 33.04
Pain Relevance 15.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
reticulum 3
neutrophils 3
plasma 2
platelet 2
Bladder 2
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 250 100.00 Very High Very High Very High
rheumatoid arthritis 162 100.00 Very High Very High Very High
antagonist 129 100.00 Very High Very High Very High
alcohol 46 99.84 Very High Very High Very High
Opioid 391 99.74 Very High Very High Very High
agonist 349 99.64 Very High Very High Very High
Dynorphin 6 99.52 Very High Very High Very High
cINOD 71 99.44 Very High Very High Very High
addiction 42 99.44 Very High Very High Very High
spinal inflammation 55 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 339 100.00 Very High Very High Very High
Rheumatoid Arthritis 187 100.00 Very High Very High Very High
Polymyalgia Rheumatica 84 99.84 Very High Very High Very High
Breast Cancer 1102 99.76 Very High Very High Very High
Constipation 31 99.48 Very High Very High Very High
Apoptosis 387 99.42 Very High Very High Very High
Low Back Pain 93 99.40 Very High Very High Very High
Malignant Neoplastic Disease 35 99.28 Very High Very High Very High
Cancer 566 99.14 Very High Very High Very High
Xerostomia 23 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
protein level (Figures 4c and 5a) through increased protein degradation (Figure 5b) and decreased abundance of ER?
Localization (abundance) of ER
1) Confidence 0.75 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.22 Pain Relevance 0.15
Her arthralgia disappeared with a few days after treatment with prednisolone (10 mg per day) was started, and ESR and CRP were normalized.
Localization (normalized) of ESR associated with arthralgia
2) Confidence 0.73 Published 2009 Journal Nippon Ronen Igakkai Zasshi Section Abstract Doc Link 19491524 Disease Relevance 1.19 Pain Relevance 0.23
Because TCZ can suppress elevation of CRP and ESR, it is inadequate to evaluate its effectiveness by clinical scores.
Localization (elevation) of ESR
3) Confidence 0.73 Published 2009 Journal Mod Rheumatol Section Body Doc Link PMC2720589 Disease Relevance 0.94 Pain Relevance 0.05
Tests for CRP and ESR were aggregated into one category.
Localization (aggregated) of ESR
4) Confidence 0.73 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575609 Disease Relevance 0.36 Pain Relevance 0.27
In vitro studies show no effect of alcohol on the release of oxymorphone ER from the matrix; however, a volunteer study (Endo Pharmaceuticals 2007) showed that following the concomitant administration of 240 mL of 20% ethanol, the Cmax increased on average by 31%, with a wide range of variation.
Localization (release) of oxymorphone ER associated with alcohol
5) Confidence 0.70 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621383 Disease Relevance 0.08 Pain Relevance 0.33
Decursin caused a concentration-dependent decrease of ER?
Localization (decrease) of ER
6) Confidence 0.70 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.11
Fresh synovial tissue specimens were assessed for the localization as well as the presence of estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) by means of immunohistochemistry, as well as Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
Localization (localization) of estrogen receptor
7) Confidence 0.69 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
In contrast, weak ER alpha staining was localized in the synovial lining cells in only three of 24 explants.
Localization (localized) of ER alpha in lining cells
8) Confidence 0.69 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
Fresh synovial tissue specimens were assessed for the localization as well as the presence of estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) by means of immunohistochemistry, as well as Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
Localization (localization) of estrogen receptor
9) Confidence 0.69 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
If Raloxifene were used, for example, its anti-estrogenic blockage of ER-alpha activity may result in a normalization of biomarkers of uterine receptivity.
Localization (blockage) of ER in uterine
10) Confidence 0.66 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.46 Pain Relevance 0.06
Similarities include observations that these agents inhibit the ligand-induced nuclear translocation of ER?
Localization (translocation) of ER
11) Confidence 0.65 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.40 Pain Relevance 0.08
This review paper will focus on oral oxymorphone extended-release (ER) in the management of CNMP.
Localization (extended-release) of ER associated with pain
12) Confidence 0.65 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621383 Disease Relevance 1.66 Pain Relevance 2.25
ER is found in approximately 1% of the population and in up to 13% of patients presenting with chest pain in the emergency room.
Localization (found) of ER in chest associated with angina and emergencies
13) Confidence 0.62 Published 2000 Journal Ugeskr. Laeg. Section Abstract Doc Link 11094554 Disease Relevance 0.36 Pain Relevance 0.18
The reasons for this variable response to opioid analgesia include differences in drug potency, differences in drug metabolism, the rate of release of IR and ER formulations, differences in opioid receptor-binding affinity, concurrent medications, production of active opioid metabolites, and differences in balance of analgesic versus hyperalgesic action of opioids (Sloan et al 2005).
Localization (release) of ER associated with hyperalgesia, analgesic, opioid receptor, opioid, potency and analgesia
14) Confidence 0.61 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621383 Disease Relevance 0.62 Pain Relevance 2.54
An extended-release (ER) formulation of tramadol was approved by the US Food and Drug Administration in September 2005.
Localization (release) of ER associated with tramadol
15) Confidence 0.61 Published 2007 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2386353 Disease Relevance 0.45 Pain Relevance 1.65
The cell-cycle arrest and apoptosis effects were accompanied by decreased ER?
Localization (decreased) of ER associated with apoptosis
16) Confidence 0.61 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.80 Pain Relevance 0
Tamoxifen and its active metabolite 4-HT have also been known to cause ER nuclear accumulation.
Localization (accumulation) of ER
17) Confidence 0.61 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.15 Pain Relevance 0.14
Furthermore, decursin (Figures 4d,e and 6c) and DA (data not shown) did not exert any 'agonist' activity in the absence of estrogen.
Neg (absence) Localization (absence) of estrogen associated with agonist
18) Confidence 0.61 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.30 Pain Relevance 0.13
In contrast, Faslodex¬ô, as expected [15], induced a sharp decrease of the cytosolic ER?
Localization (decrease) of ER
19) Confidence 0.61 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.06 Pain Relevance 0
protein abundance, mRNA level and estrogen early signaling in MCF-7 cells
Localization (abundance) of estrogen in MCF-7
20) Confidence 0.61 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.05

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