INT9236

Context Info Confidence 0.62 First Reported 1990 Last Reported 2011 Negated 30 Speculated 26 Reported most in Abstract Documents 204 Total Number 230 Disease Relevance 162.66 Pain Relevance 72.99

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF) plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)

Anatomy Link Frequency macrophages 27 monocytes 17 blood 14 leukocyte 10 adipose tissue 8 TNF (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 3135 100.00 cytokine 2278 100.00 Infliximab 655 100.00 Adalimumab 502 100.00 Inflammatory response 295 100.00 Etanercept 271 100.00 antagonist 198 100.00 cINOD 182 100.00 Neuropathic pain 164 100.00 agonist 111 100.00

Disease Link Frequency Relevance Heat INFLAMMATION 3585 100.00 Disease 1757 100.00 Cancer 1382 100.00 Obesity 790 100.00 Necrosis 516 100.00 Sepsis 384 100.00 Neuropathic Pain 286 100.00 Multiple Sclerosis 90 100.00 Insulin Resistance 78 100.00 Metabolic Syndrome 69 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Priming effect of morphine on the production of tumor necrosis factor-alpha by microglia: implications in respiratory burst activity and human immunodeficiency virus-1 expression.

Regulation (effect) of Gene_expression (production) of tumor necrosis factor in respiratory associated with necrosis, cancer, acquired immune deficiency syndrome or hiv infection and morphine

1) Confidence 0.62 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8169825 Disease Relevance 0.47 Pain Relevance 0.83

Significant costs and the requirement for continuous therapy are likely to spur the development of orally bioavailable agents targeting TNF- alpha expression.

Regulation (targeting) of Gene_expression (expression) of TNF in spur

2) Confidence 0.61 Published 2002 Journal Expert Opin Investig Drugs Section Abstract Doc Link 12084004 Disease Relevance 0.47 Pain Relevance 0.23

Thus, a PG-driven negative feedback controls TNF production in the periphery but not in the CNS.

Neg (not) Regulation (controls) of Gene_expression (production) of TNF

3) Confidence 0.61 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798931 Disease Relevance 0.57 Pain Relevance 0.58

We investigated the effect of two NSAIDs, indomethacin and ibuprofen, on the production of TNF in the CNS induced by intracerebroventricular injection of lipopolysaccharide (LPS).

Spec (investigated) Regulation (effect) of Gene_expression (production) of TNF associated with cinod and intracerebroventricular

4) Confidence 0.61 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798931 Disease Relevance 0.65 Pain Relevance 0.59

TNF production in macrophages is genetically determined and regulates inflammatory disease in rats.

Regulation (regulates) of Gene_expression (production) of TNF in macrophages associated with inflammation and disease

5) Confidence 0.60 Published 2010 Journal J. Immunol. Section Title Doc Link 20505148 Disease Relevance 1.08 Pain Relevance 0.33

Pathogenesis of nerve damage in leprosy: genetic polymorphism regulates the production of TNF alpha.

Regulation (regulates) of Gene_expression (production) of TNF alpha in nerve associated with nervous system injury and mycobacterium infection

6) Confidence 0.60 Published 2000 Journal Lepr Rev Section Title Doc Link 11201873 Disease Relevance 0.90 Pain Relevance 0.10

There was no significant change in the expression of TNF-?

Neg (no) Regulation (change) of Gene_expression (expression) of TNF

7) Confidence 0.60 Published 2008 Journal Respir Res Section Body Doc Link PMC2627837 Disease Relevance 0.41 Pain Relevance 0.29

Olprinone modulate the expression of TNF-?

Regulation (modulate) of Gene_expression (expression) of TNF

8) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 1.29 Pain Relevance 0.50

Thalidomide has several targets and mechanisms of action: a hypnosedative effect, several immunomodulatory properties with an effect on the production of TNF-alpha and the balance between the different lymphocyte subsets and an antiangiogenic action.

Regulation (effect) of Gene_expression (production) of TNF-alpha in lymphocyte

9) Confidence 0.60 Published 2004 Journal Expert Opin Drug Saf Section Abstract Doc Link 14680461 Disease Relevance 1.01 Pain Relevance 0.17

White adipose tissue regulates the production of TNF-?

Regulation (regulates) of Gene_expression (production) of TNF in adipose tissue associated with obesity

10) Confidence 0.60 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2891797 Disease Relevance 1.36 Pain Relevance 0.55

There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha).

Regulation (modulate) of Gene_expression (production) of TNF alpha associated with necrosis, cancer, catecholamine and cytokine

11) Confidence 0.59 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084220 Disease Relevance 0.20 Pain Relevance 0.42

The effects of local anesthetics on LPS- or SEB-induced TNF-alpha production were determined by using an enzyme-linked immunosorbent assay.

Regulation (effects) of Gene_expression (production) of TNF-alpha associated with local anesthetic

12) Confidence 0.58 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.28 Pain Relevance 0.79

Local anesthetics showed no effect on LPS- or SEB-induced TNF-alpha production in human whole blood.

Neg (no) Regulation (effect) of Gene_expression (production) of TNF-alpha in blood associated with local anesthetic

13) Confidence 0.58 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.29 Pain Relevance 0.95

Interestingly, an increase in neurotransmission prior to the antidepressant's effect on TNF production prevents the efficacy of the antidepressant drug.

Regulation (effect) of Gene_expression (production) of TNF associated with antidepressant

14) Confidence 0.54 Published 2005 Journal Neuroscience Section Abstract Doc Link 15878644 Disease Relevance 0.31 Pain Relevance 0.72

In this study, we evaluated the effects of morphine on tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-10 (IL-10) production in TLR2-stimulated human monocytes and identified the involvement of the different opioid receptors, and of the lymphocyte-to-monocyte contact.

Regulation (effects) of Gene_expression (production) of TNF in monocyte associated with necrosis, cancer, opioid receptor and morphine

15) Confidence 0.52 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18349186 Disease Relevance 0.35 Pain Relevance 0.35

Is there a future for TNF promoter polymorphisms?

Regulation (future) of Gene_expression (polymorphisms) of TNF promoter

16) Confidence 0.45 Published 2004 Journal Genes Immun. Section Title Doc Link 14973548 Disease Relevance 1.37 Pain Relevance 0.20

Human endotoxin-stimulated adherent monocytes were used in order to determine whether or not NSAIDs influence cyclooxygenase-2 and/or tumor necrosis factor (TNF)alpha expression within the range of inhibitor concentrations that are required to suppress prostaglandin biosynthesis.

Neg (not) Spec (whether) Regulation (influence) of Gene_expression (expression) of TNF in monocytes associated with necrosis, cancer and cinod

17) Confidence 0.45 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.20 Pain Relevance 0.13

Thus it is possible that the TNF-neutralizing effect is intermittent: molecules of sTNF and LT?

Spec (possible) Regulation (intermittent) of Gene_expression (effect) of TNF-neutralizing

18) Confidence 0.45 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.38 Pain Relevance 0.22

Studies of chronic and acute stress in models of human stress have shown higher circulating levels of IL-6 and TNF?

Regulation (circulating) of Gene_expression (levels) of TNF associated with stress

19) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991021 Disease Relevance 1.55 Pain Relevance 0.97

The influence of intratumoral injections of TNF on the activity of NK lymphocytes and macrophages in vivo

Regulation (influence) of Gene_expression (injections) of TNF in lymphocytes

20) Confidence 0.44 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766459 Disease Relevance 1.35 Pain Relevance 0

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