INT92369

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Context Info
Confidence 0.25
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 1.73

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nucleoplasm (RYBP) mitochondrion (CYP2D6) small molecule metabolic process (CYP2D6)
oxidoreductase activity (CYP2D6) endoplasmic reticulum (CYP2D6) nucleus (RYBP)
CYP2D6 (Homo sapiens)
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 22 100.00 Very High Very High Very High
Analgesic 2 71.60 Quite High
Dextromethorphan 2 64.16 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
K(m) and V(max) values were 1.76 mM and 3.02 nmol/min/nmol of P450, respectively, such that the efficiency of CYP2D6 in the conversion of APAP to NAPQI is approximately one-third of that of CYP2E1.
CYP2D6 Binding (efficiency) of APAP associated with paracetamol
1) Confidence 0.25 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 11095574 Disease Relevance 0.07 Pain Relevance 0.87
K(m) and V(max) values were 1.76 mM and 3.02 nmol/min/nmol of P450, respectively, such that the efficiency of CYP2D6 in the conversion of APAP to NAPQI is approximately one-third of that of CYP2E1.
CYP2D6 Binding (efficiency) of APAP associated with paracetamol
2) Confidence 0.25 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 11095574 Disease Relevance 0.07 Pain Relevance 0.87

General Comments

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