INT9237

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Context Info
Confidence 0.62
First Reported 1988
Last Reported 2010
Negated 9
Speculated 9
Reported most in Abstract
Documents 49
Total Number 58
Disease Relevance 30.69
Pain Relevance 20.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
monocytes 10
cartilage 8
blood 6
chondrocytes 4
PGE2 4
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 729 100.00 Very High Very High Very High
Inflammation 536 100.00 Very High Very High Very High
cINOD 68 100.00 Very High Very High Very High
COX2 4 100.00 Very High Very High Very High
Osteoarthritis 315 99.98 Very High Very High Very High
methotrexate 194 99.92 Very High Very High Very High
Pain 262 99.88 Very High Very High Very High
Angina 6 99.68 Very High Very High Very High
rheumatoid arthritis 497 99.64 Very High Very High Very High
IPN 21 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 612 100.00 Very High Very High Very High
Cancer 90 100.00 Very High Very High Very High
Necrosis 54 100.00 Very High Very High Very High
Osteoarthritis 324 99.98 Very High Very High Very High
Pain 276 99.88 Very High Very High Very High
Cv General 3 Under Development 7 99.68 Very High Very High Very High
Rheumatoid Arthritis 511 99.64 Very High Very High Very High
Adhesions 21 99.58 Very High Very High Very High
Disorders Of The Lacrimal System 24 99.54 Very High Very High Very High
Fibromyalgia 170 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of antirheumatic drugs on interleukin 1 (IL-1) activity and IL-1 and IL-1 inhibitor production by human monocytes.
Regulation (effect) of Gene_expression (production) of IL-1 in monocytes associated with methotrexate
1) Confidence 0.62 Published 1990 Journal J. Rheumatol. Section Title Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.39
The objective of our study was to investigate the effect of a number of representative antirheumatic agents on the activity of IL-1 and the production of both IL-1 and IL-1 inhibitor by human monocytes.
Spec (investigate) Regulation (effect) of Gene_expression (production) of IL-1 in monocytes
2) Confidence 0.62 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.27
Methotrexate inhibited IL-1 activity without affecting IL-1 production.
Neg (without) Regulation (affecting) of Gene_expression (production) of IL-1 associated with methotrexate
3) Confidence 0.62 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.24 Pain Relevance 0.40
We hypothesise that the P2X(7) receptor, via regulation of mature IL-1beta production, plays a common upstream transductional role in the development of pain of neuropathic and inflammatory origin.
Regulation (regulation) of Gene_expression (production) of IL-1beta associated with pain, inflammation and neuropathic pain
4) Confidence 0.60 Published 2005 Journal Pain Section Abstract Doc Link 15777864 Disease Relevance 1.05 Pain Relevance 0.58
Neither adrenocorticotrophic hormone (ACTH), prolactin, serum interleukin-1beta (IL-1beta) nor mitogen stimulated IL-1beta production was influenced at any time.
Regulation (influenced) of Gene_expression (production) of IL-1beta
5) Confidence 0.60 Published 2000 Journal Psychoneuroendocrinology Section Abstract Doc Link 10725611 Disease Relevance 0.50 Pain Relevance 0.12
We investigated the effects of an NSAID, flurbiprofen, on production of the cytokines tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL-1 beta) and interleukin 6 (IL-6) by human peripheral blood monocytes and by the human cell lines U-937 and THP-1.
Spec (investigated) Regulation (effects) of Gene_expression (production) of interleukin 1 beta in blood associated with necrosis, cancer, cinod and cytokine
6) Confidence 0.55 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1404130 Disease Relevance 0.48 Pain Relevance 0.41
In addition, augmented levels of IL1-beta transcript were not noted in unstimulated sarcoid alveolar macrophages.
Neg (not) Regulation (noted) of Gene_expression (levels) of IL1-beta in alveolar macrophages associated with sarcoidosis
7) Confidence 0.45 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.74 Pain Relevance 0.10
The objective of our study was to investigate the effect of a number of representative antirheumatic agents on the activity of IL-1 and the production of both IL-1 and IL-1 inhibitor by human monocytes.
Spec (investigate) Regulation (effect) of Gene_expression (production) of IL-1 in monocytes
8) Confidence 0.45 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.27
The effect of antirheumatic drugs on interleukin 1 (IL-1) activity and IL-1 and IL-1 inhibitor production by human monocytes.
Regulation (effect) of Gene_expression (production) of IL-1 in monocytes associated with methotrexate
9) Confidence 0.45 Published 1990 Journal J. Rheumatol. Section Title Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.39
The objective of our study was to investigate the effect of a number of representative antirheumatic agents on the activity of IL-1 and the production of both IL-1 and IL-1 inhibitor by human monocytes.
Spec (investigate) Regulation (effect) of Gene_expression (production) of IL-1 in monocytes
10) Confidence 0.45 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.27
Since high levels of prostaglandin (PG) E2 and interleukin (IL)-1 beta are found in the periodontal ligament (PDL) during tooth movement, and both factors are involved in the induction of pain, the effects of low-power laser irradiation on PGE2 and IL-1 beta production in stretched human PDL cells were studied in vitro.
Regulation (effects) of Gene_expression (production) of IL-1 beta in PDL associated with pain
11) Confidence 0.44 Published 1995 Journal J. Dent. Res. Section Abstract Doc Link 7560389 Disease Relevance 0.36 Pain Relevance 0.36
We found no association between serum IL-1beta level and age, sex, consumption of cardioactive drugs and serum levels of IL-1Ra, IL-6, sIL-6R, IL-10 and TNF-alpha.
Neg (no) Regulation (association) of Gene_expression (levels) of IL-1beta
12) Confidence 0.44 Published 2003 Journal Cytokine Section Abstract Doc Link 12890453 Disease Relevance 0.40 Pain Relevance 0.17
OBJECTIVES: To determine the effects of two drugs, N-monomethyl-L-arginine (L-NMMA) and N-acetylcysteine (NAC), on interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production by human chondrocytes.
Spec (determine) Regulation (effects) of Gene_expression (production) of interleukin-1beta in chondrocytes
13) Confidence 0.44 Published 2002 Journal Osteoarthr. Cartil. Section Abstract Doc Link 12127835 Disease Relevance 0 Pain Relevance 0.09
Together these observations support a primary or secondary role for the inflammatory cytokines IL6, IL1?
Regulation (role) of Gene_expression (cytokines) of IL1 associated with inflammation and cytokine
14) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.39 Pain Relevance 0.83
The production of IL-1beta, IL-6, and TNF-alpha by the ATCC 1739 cells was no different in H. pylori-exposed cells than non-exposed cells.
Neg (no) Regulation (different) of Gene_expression (production) of IL-1beta
15) Confidence 0.44 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17160356 Disease Relevance 0.83 Pain Relevance 0.35
at the DR-1/AP-1 sites in IL-1?
Regulation (at) of Gene_expression (sites) of IL-1
16) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.05 Pain Relevance 0
DESIGN: In twelve OA of the TMJ (OA-TMJ) affected patients and in six healthy volunteer subjects studied as control, the expression of IL1beta (interleukin-1beta), IL2, IL4, IL5, IL6, IL10, IL12p35, IL12p40, IL17, IFNgamma (interferon-gamma), TNFalpha (tumor necrosis factor-alpha), and TNFbeta mRNAs was evaluated.
Regulation (evaluated) of Gene_expression (expression) of IL1beta in TMJ
17) Confidence 0.44 Published 2008 Journal Arch. Oral Biol. Section Body Doc Link 18508030 Disease Relevance 0.19 Pain Relevance 0
at the DR-1/AP-1 site in IL-1?
Regulation (at) of Gene_expression (site) of IL-1
18) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.07 Pain Relevance 0
We investigated the effects of an NSAID, flurbiprofen, on production of the cytokines tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL-1 beta) and interleukin 6 (IL-6) by human peripheral blood monocytes and by the human cell lines U-937 and THP-1.
Spec (investigated) Regulation (effects) of Gene_expression (production) of IL-1 beta in blood associated with necrosis, cancer, cinod and cytokine
19) Confidence 0.40 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1404130 Disease Relevance 0.48 Pain Relevance 0.41
In contrast, the cyclooxygenase (CO) inhibitors (naproxen and ibuprofen) and the lipoxygenase (5-LO) inhibitors (zileuton, L-663536 and BWA4C) did not effect IL-1 beta or TNF-alpha release/biosynthesis.
Neg (not) Regulation (effect) of Gene_expression (biosynthesis) of IL-1 beta
20) Confidence 0.37 Published 1993 Journal Agents Actions Section Abstract Doc Link 8273590 Disease Relevance 0.15 Pain Relevance 0.21

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