INT92370

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Context Info
Confidence 0.21
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6, CYP2D6) endoplasmic reticulum (CYP2B6, CYP2D6) mitochondrion (CYP2D6)
oxidoreductase activity (CYP2D6)
Anatomy Link Frequency
plasma 1
CYP2B6 (Homo sapiens)
CYP2D6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 11 97.52 Very High Very High Very High
Dextromethorphan 1 94.72 High High
Analgesic 1 45.92 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 1 48.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings indicate that CYP2D6, one of the major P450 isoforms in humans and also one of the pharmacogenetically important isoforms, may contribute significantly to the formation of the cytotoxic metabolite NAPQI, especially in CYP2D6 ultra-rapid and extensive metabolizers and at toxic doses of APAP when plasma APAP concentrations reach 2 mM or more.
P450 Binding (contribute) of CYP2D6 in plasma associated with paracetamol
1) Confidence 0.21 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 11095574 Disease Relevance 0 Pain Relevance 0.73

General Comments

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