INT92372

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Context Info
Confidence 0.17
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
nucleus (RYBP) intracellular (RYBP) DNA binding (RYBP)
CYP2B6 (Homo sapiens)
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 11 100.00 Very High Very High Very High
Analgesic 1 90.52 High High
Dextromethorphan 1 26.64 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 1 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is generally accepted that N-acetyl-p-benzoquinone imine (NAPQI) is the toxic, reactive intermediate whose formation from APAP is mediated by cytochrome P450.
P450 Positive_regulation (mediated) of APAP Binding (formation) of associated with paracetamol
1) Confidence 0.17 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 11095574 Disease Relevance 0.09 Pain Relevance 0.81

General Comments

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