INT9238

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 17
Speculated 34
Reported most in Abstract
Documents 1575
Total Number 1609
Disease Relevance 1135.66
Pain Relevance 424.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 73
blood 40
macrophages 39
monocytes 36
fibroblasts 30
IL6 (Homo sapiens)
IL6 - R753Q (1)
Pain Link Frequency Relevance Heat
Inflammation 22770 100.00 Very High Very High Very High
cytokine 21362 100.00 Very High Very High Very High
rheumatoid arthritis 7309 100.00 Very High Very High Very High
Osteoarthritis 4194 100.00 Very High Very High Very High
chemokine 2629 100.00 Very High Very High Very High
Inflammatory response 2180 100.00 Very High Very High Very High
antagonist 1296 100.00 Very High Very High Very High
metalloproteinase 1150 100.00 Very High Very High Very High
depression 1109 100.00 Very High Very High Very High
Inflammatory marker 793 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 27719 100.00 Very High Very High Very High
Cancer 9945 100.00 Very High Very High Very High
Rheumatoid Arthritis 8036 100.00 Very High Very High Very High
Infection 4521 100.00 Very High Very High Very High
Stress 3546 100.00 Very High Very High Very High
Atherosclerosis 3272 100.00 Very High Very High Very High
Osteoporosis 2589 100.00 Very High Very High Very High
Necrosis 1858 100.00 Very High Very High Very High
Adhesions 1788 100.00 Very High Very High Very High
Sepsis 1671 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6, which is produced very early in inflammation, survives only briefly in the human body and its levels fluctuate within individuals.
Gene_expression (produced) of IL-6 in body associated with inflammation
1) Confidence 0.78 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2288623 Disease Relevance 1.68 Pain Relevance 0.38
The researchers measured baseline IL-6 blood levels in these participants and in 4,267 similar participants who had not had a CHD event.
Gene_expression (levels) of IL-6 in blood associated with coronary heart disease
2) Confidence 0.78 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2288623 Disease Relevance 1.29 Pain Relevance 0.23
Moreover, in cases of CP with inflammatory infiltration, there were a markedly stronger IL-6 expression, than that observed in specimens without infiltrate.
Gene_expression (expression) of IL-6 associated with inflammation and chronic pancreatitis
3) Confidence 0.78 Published 2008 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 18091322 Disease Relevance 0.67 Pain Relevance 0.59
In conclusion, the results presented herein clearly demonstrated a moderate and strong expression of IL-6 in exocrine and endocrine cells of patients with CP.
Gene_expression (expression) of IL-6 in endocrine cells associated with chronic pancreatitis
4) Confidence 0.78 Published 2008 Journal Appl. Immunohistochem. Mol. Morphol. Section Abstract Doc Link 18091322 Disease Relevance 0.64 Pain Relevance 0.56
In the present case, elevation of IL-6 was detected, suggesting that IL-6 produced by ATL cells is related to their proliferation in the bone, and local osteolysis.
Gene_expression (produced) of IL-6 associated with osteolysis and htlv types i and ii
5) Confidence 0.78 Published 1999 Journal Intern. Med. Section Abstract Doc Link 10526948 Disease Relevance 0.69 Pain Relevance 0.08
Serum interleukin-6 levels correlated with these symptoms; the level was high before chemotherapy, but the levels were decreased during the courses of FP therapy.
Gene_expression (levels) of interleukin-6
6) Confidence 0.78 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10522052 Disease Relevance 0.63 Pain Relevance 0.10
The antiviral effects of tenidap may be independent of its ability to reduce IL-6 production based on the observations that these effects were as prominent in IL-6 nonresponsive lines as in IL-6 responsive lines and that the inhibition of p24 production was not reversed by exogenous IL-6.
Gene_expression (production) of IL-6
7) Confidence 0.78 Published 1997 Journal J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. Section Abstract Doc Link 8989205 Disease Relevance 0.45 Pain Relevance 0.08
Tenidap, a structurally and functionally novel antirheumatic drug affecting diverse biologic processes, has been shown to reduce IL-6 production by peripheral blood mononuclear cells stimulated with lipopolysaccharide.
Gene_expression (production) of IL-6 in mononuclear cells
8) Confidence 0.78 Published 1997 Journal J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. Section Abstract Doc Link 8989205 Disease Relevance 0.39 Pain Relevance 0.07
Kiecolt-Glaser et al. [36] found that couples with a high frequency of hostile marital interactions, ‘high-hostile couples’, developed larger increases in plasma levels of IL-6 and TNF?
Gene_expression (levels) of IL-6 in plasma
9) Confidence 0.77 Published 2010 Journal Journal of Psychosomatic Research Section Body Doc Link PMC2809922 Disease Relevance 0.66 Pain Relevance 0.09
We investigated in the human astrocytoma cell line U373 whether tenidap inhibits IL-6 synthesis by inhibition of certain signal transduction processes leading to IL-6 synthesis.
Gene_expression (synthesis) of IL-6 associated with anaplastic astrocytoma
10) Confidence 0.77 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.50 Pain Relevance 0.22
Tenidap was a very potent inhibitor of IL-6 synthesis independent of the stimuli used, suggesting an inhibitory mechanism other than inhibition of a certain signal transduction pathway.
Gene_expression (synthesis) of IL-6
11) Confidence 0.77 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.54 Pain Relevance 0.26
Potent inhibition of interleukin-6 expression in a human astrocytoma cell line by tenidap.
Gene_expression (expression) of interleukin-6 associated with anaplastic astrocytoma
12) Confidence 0.77 Published 1997 Journal Cell Tissue Res. Section Title Doc Link 9082960 Disease Relevance 0.56 Pain Relevance 0.28
Cells were stimulated with different substances which have previously been shown to activate protein kinase A or C, reactive oxygen intermediates as well as transcription factors such as nuclear factor kappa B and AP-1 and which all result in IL-6 synthesis.
Gene_expression (synthesis) of IL-6
13) Confidence 0.77 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.54 Pain Relevance 0.26
We investigated in the human astrocytoma cell line U373 whether tenidap inhibits IL-6 synthesis by inhibition of certain signal transduction processes leading to IL-6 synthesis.
Gene_expression (synthesis) of IL-6 associated with anaplastic astrocytoma
14) Confidence 0.77 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.55 Pain Relevance 0.27
Previous studies have shown that tenidap is able to inhibit the production and action of cytokines such as interleukin-1, interleukin-6 (IL-6) and tumour necrosis factor alpha.
Gene_expression (production) of interleukin-6 associated with necrosis, cancer and cytokine
15) Confidence 0.77 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.46 Pain Relevance 0.24
Previous studies have shown that tenidap is able to inhibit the production and action of cytokines such as interleukin-1, interleukin-6 (IL-6) and tumour necrosis factor alpha.
Gene_expression (production) of IL-6 associated with necrosis, cancer and cytokine
16) Confidence 0.77 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.46 Pain Relevance 0.24
While the effects of naproxen and meloxicam were small and restricted to protein synthesis, tenidap strongly inhibited IL-6 protein synthesis and also affected IL-6 mRNA levels.
Gene_expression (synthesis) of IL-6
17) Confidence 0.77 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.54 Pain Relevance 0.50
In the present study, the effects of seven non-steroidal anti-inflammatory drugs (NSAIDs) on interleukin-1 beta (IL-1 beta)-induced IL-6 mRNA expression and protein synthesis in a human astrocytoma cell line were investigated.
Gene_expression (synthesis) of IL-6 associated with anaplastic astrocytoma, inflammation and cinod
18) Confidence 0.77 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.63 Pain Relevance 0.50
Tenidap, naproxen and meloxicam inhibited the IL-1 beta-induced synthesis of IL-6, whereas ibuprofen, piroxicam, diclofenac and indomethacin had no effect.
Gene_expression (synthesis) of IL-6 associated with diclofenac
19) Confidence 0.77 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.59 Pain Relevance 0.50
Lung cancer producing interleukin-6.
Gene_expression (producing) of interleukin-6 in Lung associated with lung cancer
20) Confidence 0.77 Published 1996 Journal Intern. Med. Section Title Doc Link 8785456 Disease Relevance 0.65 Pain Relevance 0.10

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