INT92382

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.82
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KRAS) mitochondrion (KRAS) plasma membrane (KRAS)
GTPase activity (KRAS)
Anatomy Link Frequency
monocytes 4
Caco-2 4
KRAS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 23 99.96 Very High Very High Very High
Inflammation 81 99.24 Very High Very High Very High
cINOD 3 84.44 Quite High
agonist 26 83.04 Quite High
alcohol 2 68.16 Quite High
Inflammatory mediators 4 32.96 Quite Low
COX2 3 25.00 Low Low
fibrosis 9 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 26 99.92 Very High Very High Very High
Hepatitis C Virus Infection 16 99.80 Very High Very High Very High
Colon Cancer 35 99.26 Very High Very High Very High
INFLAMMATION 91 99.24 Very High Very High Very High
Hepatitis B Virus Infection 16 95.24 Very High Very High Very High
Cancer 137 94.44 High High
Targeted Disruption 28 87.04 High High
Severe Combined Immunodeficiency 2 85.84 High High
Hepatocellular Cancer 94 84.12 Quite High
Nash(non-alcoholic Steatohepatitis) 18 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HCV core and NS3 proteins activate TLR2 on monocytes to induce cytokines in a NF-?
Positive_regulation (activate) of Gene_expression (proteins) of NS3 in monocytes associated with hepatitis c virus infection and cytokine
1) Confidence 0.49 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.29 Pain Relevance 0.20
The HCV core and NS3 proteins activate TLR2 on monocytes to induce cytokines in a NF-?
Positive_regulation (induce) of Gene_expression (proteins) of NS3 in monocytes associated with hepatitis c virus infection and cytokine
2) Confidence 0.49 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.29 Pain Relevance 0.20
Recent updates of the two large phase III studies comparing BSC and therapy with cetuximab or panitumumab have confirmed that KRAS analysis presently is the best way to identify patients with the lowest chance to benefit from EGFR-inhibition, as only 1 patient among a total of more than 160 patients with KRAS mutations achieved response to EGFR-inhibition.55,56,67,68
Positive_regulation (presently) of Gene_expression (analysis) of KRAS
3) Confidence 0.46 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886318 Disease Relevance 0.22 Pain Relevance 0
Recent updates of the two large phase III studies comparing BSC and therapy with cetuximab or panitumumab have confirmed that KRAS analysis presently is the best way to identify patients with the lowest chance to benefit from EGFR-inhibition, as only 1 patient among a total of more than 160 patients with KRAS mutations achieved response to EGFR-inhibition.55,56,67,68
Positive_regulation (comparing) of Gene_expression (analysis) of KRAS
4) Confidence 0.46 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886318 Disease Relevance 0.22 Pain Relevance 0
Expression of an activated K-ras oncogene caused cells treated with either sulindac sulfide or sulfone to undergo apoptosis earlier than nontransfected controls.
Positive_regulation (activated) of Gene_expression (Expression) of K-ras oncogene associated with apoptosis
5) Confidence 0.37 Published 2000 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 11097222 Disease Relevance 0.66 Pain Relevance 0.07
0.5 fold of control), while cyclin A1 and KRAS were up-regulated ?
Positive_regulation (while) of Gene_expression (were) of KRAS
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.08 Pain Relevance 0.07
We studied the effects of these sulindac metabolites in human colon cancer-derived Caco-2 cells that have been transfected with an activated K-ras oncogene.
Positive_regulation (activated) of Gene_expression (transfected) of K-ras oncogene in Caco-2 associated with colon cancer
7) Confidence 0.12 Published 2000 Journal Cancer Res. Section Abstract Doc Link 11118042 Disease Relevance 0.53 Pain Relevance 0.08
We studied the effects of these sulindac metabolites in human colon cancer-derived Caco-2 cells that have been transfected with an activated K-ras oncogene.
Positive_regulation (transfected) of Gene_expression (transfected) of K-ras oncogene in Caco-2 associated with colon cancer
8) Confidence 0.12 Published 2000 Journal Cancer Res. Section Abstract Doc Link 11118042 Disease Relevance 0.53 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox