INT92386

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2011
Negated 5
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 13.55
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf8) molecular_function (Tnfrsf8) cellular_component (Tnfrsf8)
Anatomy Link Frequency
T-cell 5
macrophage 1
B cell 1
lymphoid tissue 1
Tnfrsf8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 38 88.68 High High
Pain 7 88.64 High High
headache 5 86.52 High High
Central nervous system 12 81.12 Quite High
abdominal pain 13 80.84 Quite High
Bile 5 75.36 Quite High
Chronic pancreatitis 6 61.68 Quite High
Inflammation 10 54.88 Quite High
spinal inflammation 4 50.00 Quite Low
corticosteroid 26 24.48 Low Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 102 100.00 Very High Very High Very High
Diffuse Large B-cell Lymphoma 21 99.90 Very High Very High Very High
Epstein-barr Virus 8 99.56 Very High Very High Very High
Disease 186 99.04 Very High Very High Very High
Anaplastic Large Cell Lymphoma 14 98.76 Very High Very High Very High
Cancer 25 98.68 Very High Very High Very High
Histiocytic Sarcoma 8 98.64 Very High Very High Very High
Plasmacytoma 4 97.64 Very High Very High Very High
Lymphomatoid Papulosis 4 94.72 High High
Splenic Rupture 2 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, CD30 and anaplastic lymphoma kinase 1 (ALK) were diffusely positive, thus, representing a case of anaplastic large cell lymphoma (ALCL), T-cell, ALK-positive, small cell monomorphic variant.
Gene_expression (positive) of CD30 in T-cell associated with lymphatic system cancer and anaplastic large cell lymphoma
1) Confidence 0.54 Published 2000 Journal Virchows Arch. Section Abstract Doc Link 11097375 Disease Relevance 1.13 Pain Relevance 0.09
Apart from large cell lymphomas the CD30 antigen is expressed in various cell lineages such as malignant histiocytosis, plasmacytoma, some non-Hodgkin lymphomas other than large cell lymphoma, lymphomatoid papulosis and certainly Hodgkin's disease [3,13].
Gene_expression (expressed) of CD30 associated with plasmacytoma, lymphatic system cancer, histiocytic sarcoma, disease, diffuse large b-cell lymphoma and lymphomatoid papulosis
2) Confidence 0.14 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2117016 Disease Relevance 1.49 Pain Relevance 0
A predominant expression of CD30, CD15 and EBV-LMP1 were seen in the cells while being weakly positive for CD20.
Gene_expression (expression) of CD30 associated with epstein-barr virus
3) Confidence 0.14 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2117016 Disease Relevance 0.98 Pain Relevance 0
Our patient showed co expression of both CD30 and CD15, which is commonly associated with Hodgkin's disease [8].
Gene_expression (expression) of CD30 associated with disease
4) Confidence 0.14 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2117016 Disease Relevance 1.56 Pain Relevance 0
In the case of our patient the specimens initially immunologically stained were positive for CD30 and hence a misdiagnosis of CD30 positive large cell lymphoma was made.
Gene_expression (positive) of CD30 associated with diffuse large b-cell lymphoma
5) Confidence 0.13 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2117016 Disease Relevance 1.35 Pain Relevance 0
Immunohistochemical stains showed diffuse strong positivity for CD8, CD30, anaplastic lymphoma kinase protein: p80 and negative monocyte-macrophage and B cell markers.
Gene_expression (positivity) of CD30 in macrophage associated with lymphatic system cancer
6) Confidence 0.10 Published 2008 Journal J. Pediatr. Hematol. Oncol. Section Abstract Doc Link 19131793 Disease Relevance 0.86 Pain Relevance 0.35
Histologic and immunohistochemical studies of a stereotactic biopsy of the mass showed a T-cell lymphoproliferative lesion positive for CD3, CD8, CD57, and T-cell intracellular antigen 1 and negative for CD4, CD56, CD30, anaplastic lymphoma kinase, and CD20.
Neg (negative) Gene_expression (negative) of CD30 in T-cell associated with lymphatic system cancer
7) Confidence 0.05 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 12717253 Disease Relevance 0.95 Pain Relevance 0.20
These neoplastic cells expressed CD30, CD43, granzyme B and T-cell intracellular antigen-1, but not ALK1, CD3, CD20, CD45, CD79a, cytokeratin, and EMA.
Neg (not) Gene_expression (expressed) of CD30 in T-cell
8) Confidence 0.05 Published 2001 Journal Pathol. Res. Pract. Section Abstract Doc Link 11569930 Disease Relevance 0.40 Pain Relevance 0.09
Immunohistochemistry revealed that the tumor cells were positive for LCA, CD3, TIA-1 and granzyme B, but were negative for CD4, CD8, CD56, CD30, L-26, EMA, TCR alpha/beta and TCR gamma/delta.
Neg (negative) Gene_expression (negative) of CD30 associated with cancer
9) Confidence 0.04 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 11107059 Disease Relevance 0.68 Pain Relevance 0.08
Surface antigen expression was further investigated in cultured cells, showing that the cultured cells did not express representative B-cell markers, except for CD20, as well as T-cell markers, but were positive for CD16, CD30, and CD103.
Gene_expression (positive) of CD30 in T-cell
10) Confidence 0.04 Published 2005 Journal Virchows Arch. Section Abstract Doc Link 16021507 Disease Relevance 1.24 Pain Relevance 0.07
Immunohistochemical stains showed diffuse strong positivity for CD8, CD30, anaplastic lymphoma kinase protein: p80 and negative monocyte-macrophage and B cell markers.
Gene_expression (positivity) of CD30 in B cell associated with lymphatic system cancer
11) Confidence 0.04 Published 2008 Journal J. Pediatr. Hematol. Oncol. Section Abstract Doc Link 19131793 Disease Relevance 0.86 Pain Relevance 0.35
Immunophenotypic analysis by flow cytometry was performed (CD45, CD3, CD4, CD8, CD4+/CD8+ T cell ratio, CD19, CD16, CD56, CD23, CD25 and CD30 were assayed).
Gene_expression (assayed) of CD30 in T cell
12) Confidence 0.03 Published 2007 Journal Joint Bone Spine Section Body Doc Link 17387033 Disease Relevance 0.06 Pain Relevance 0
There was no expression of CD56, CD30, CD3, CD20 and CD10.
Neg (no) Gene_expression (expression) of CD30
13) Confidence 0.03 Published 2008 Journal Oral Maxillofac Surg Section Body Doc Link PMC2516198 Disease Relevance 1.28 Pain Relevance 0.03
Pathology on duodenal biopsies revealed marked expansion of atypical lymphoid tissue, positive staining for CD20, BCL-6, BCL-2, CD10, and KI-67 and negative for CD5, CD23, Tdt, BCL-1, and CD30. cMYC translocation was negative and there was a light chain but not heavy chain rearrangement present.
Neg (negative) Gene_expression (negative) of CD30 in lymphoid tissue
14) Confidence 0.01 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 0.71 Pain Relevance 0.41

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