INT92388

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 7
Speculated 0
Reported most in Body
Documents 16
Total Number 21
Disease Relevance 22.46
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ALK) signal transduction (ALK) plasma membrane (ALK)
Anatomy Link Frequency
smooth muscle 2
T-cell 2
blood 1
urinary bladder 1
lymphocytes 1
ALK (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 37 98.64 Very High Very High Very High
Pain 5 98.28 Very High Very High Very High
imagery 6 96.92 Very High Very High Very High
vincristine 1 91.84 High High
positron emission tomography 1 90.00 High High
Central nervous system 13 89.76 High High
abdominal pain 13 86.76 High High
cva 3 83.08 Quite High
Arthritis 1 82.40 Quite High
Angina 1 78.16 Quite High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 775 100.00 Very High Very High Very High
Anaplastic Large Cell Lymphoma 132 99.96 Very High Very High Very High
Cancer 360 99.68 Very High Very High Very High
Necrosis 9 99.40 Very High Very High Very High
Genetic Translocation 7 99.28 Very High Very High Very High
Epstein-barr Virus 192 99.12 Very High Very High Very High
INFLAMMATION 36 98.64 Very High Very High Very High
Pain 4 98.28 Very High Very High Very High
Overactive Bladder 2 97.96 Very High Very High Very High
Fat Necrosis 1 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining also showed an overexpression of ALK in the tumor.
Gene_expression (overexpression) of ALK associated with cancer
1) Confidence 0.78 Published 2009 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20058697 Disease Relevance 1.09 Pain Relevance 0.33
In this patient, anaplastic lymphoma kinase (ALK) expression was also positive, whereas it was negative in patient 1.
Gene_expression (expression) of ALK associated with lymphatic system cancer
2) Confidence 0.75 Published 2003 Journal Hum. Pathol. Section Abstract Doc Link 12673560 Disease Relevance 1.13 Pain Relevance 0.21
A distinct pathologic entity characterized by expression of the anaplastic lymphoma kinase (ALK) protein (hence described as ALK lymphoma) has emerged within the heterogeneous group of CD30 anaplastic large-cell lymphomas.
Gene_expression (expression) of ALK associated with lymphatic system cancer
3) Confidence 0.75 Published 2008 Journal J. Pediatr. Hematol. Oncol. Section Abstract Doc Link 19131793 Disease Relevance 0.65 Pain Relevance 0.23
ALK, smooth muscle actin, and vimentin staining were observed in all tumors.
Gene_expression (observed) of ALK in smooth muscle associated with cancer
4) Confidence 0.65 Published 2010 Journal Pathol. Res. Pract. Section Abstract Doc Link 20304564 Disease Relevance 1.26 Pain Relevance 0.20
ALK, smooth muscle actin, and vimentin staining were observed in all tumors.
Gene_expression (staining) of ALK in smooth muscle associated with cancer
5) Confidence 0.65 Published 2010 Journal Pathol. Res. Pract. Section Abstract Doc Link 20304564 Disease Relevance 1.26 Pain Relevance 0.20
In addition, CD30 and anaplastic lymphoma kinase 1 (ALK) were diffusely positive, thus, representing a case of anaplastic large cell lymphoma (ALCL), T-cell, ALK-positive, small cell monomorphic variant.
Gene_expression (positive) of ALK in T-cell associated with lymphatic system cancer and anaplastic large cell lymphoma
6) Confidence 0.65 Published 2000 Journal Virchows Arch. Section Abstract Doc Link 11097375 Disease Relevance 1.13 Pain Relevance 0.09
An autopsy of the pancreas revealed clusters of large, atypical cells, which morphologically and immunophenotypically were consistent with CD30 positive, ALK-negative anaplastic large cell lymphoma (ALCL) of T-cell lineage and multifocal fat necrosis (panniculitis) in the peripancreatic adipose tissue.
Neg (negative) Gene_expression (negative) of ALK in T-cell associated with fat necrosis, obesity, anaplastic large cell lymphoma and panniculitis
7) Confidence 0.65 Published 2006 Journal Haematologica Section Abstract Doc Link 17194661 Disease Relevance 1.15 Pain Relevance 0.09
[A case of inflammatory myofibroblastic tumor of the urinary bladder finally diagnosed by anaplastic lymphoma kinase (ALK) immunostaining].
Gene_expression (immunostaining) of ALK in urinary bladder associated with lymphatic system cancer, inflammation and cancer
8) Confidence 0.65 Published 2006 Journal Hinyokika Kiyo Section Title Doc Link 16758729 Disease Relevance 0.82 Pain Relevance 0.23
Excisional biopsy from the destructive mass showed anaplastic large cell lymphoma (CD 30 was positive and ALK negative).
Neg (negative) Gene_expression (negative) of ALK associated with anaplastic large cell lymphoma
9) Confidence 0.58 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18301899 Disease Relevance 0.76 Pain Relevance 0.21
The latter endorse the low-grade neoplastic nature of this entity owing to (a) the occurrence of cases with deep infiltration of the bladder wall and extension into the perivesical soft tissue and (b) the demonstration of a non-random chromosomal translocation involving 2p23 that results in the expression of anaplastic lymphoma kinase (ALK) [5].
Gene_expression (expression) of ALK in bladder associated with lymphatic system cancer and genetic translocation
10) Confidence 0.58 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2292680 Disease Relevance 1.35 Pain Relevance 0.07
Immunostaining showed positiveness for CD15, CD30 and LMP-1 while CD3, EMA and ALK were negative.
Neg (negative) Gene_expression (negative) of ALK
11) Confidence 0.44 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435921 Disease Relevance 1.20 Pain Relevance 0.08
At immunohistochemistry, HRSCs expressed the following molecules: CD30+, CD43+, CD15+/-, CD3+/-; and were negative for EMA, ALK and CD20.
Neg (negative) Gene_expression (negative) of ALK
12) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208867 Disease Relevance 1.00 Pain Relevance 0.09
Nucleophosmin (NPM)-ALK, the characteristic fusion gene oncoprotein expressed in ALK(+)ALCL, directly contributes to the aberrant expression of IL-22R1, as transfection of NPM-ALK in Jurkat cells induced IL-22R1 expression and IL-22-mediated STAT3 activation [18].
Gene_expression (expressed) of ALK associated with anaplastic large cell lymphoma
13) Confidence 0.12 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.47 Pain Relevance 0
CK, HMB45 and ALK were negative.
Neg (negative) Gene_expression (negative) of ALK
14) Confidence 0.10 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1276822 Disease Relevance 1.70 Pain Relevance 0.17
6) ALK expression.
Gene_expression (expression) of ALK
15) Confidence 0.10 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.60 Pain Relevance 0.03
The expression of IL-22R1 in ALK(+)ALCL is aberrant, as this protein is absent in benign lymphocytes.
Gene_expression (expression) of ALK in lymphocytes associated with anaplastic large cell lymphoma
16) Confidence 0.10 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.35 Pain Relevance 0
3), whereas the PAX5, BCL6, BCL1 cyclin D1, and ALK genes were in germline configuration.
Gene_expression (genes) of ALK in germline
17) Confidence 0.10 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.35 Pain Relevance 0
Nucleophosmin (NPM)-ALK, the characteristic fusion gene oncoprotein expressed in ALK(+)ALCL, directly contributes to the aberrant expression of IL-22R1, as transfection of NPM-ALK in Jurkat cells induced IL-22R1 expression and IL-22-mediated STAT3 activation [18].
Gene_expression (transfection) of NPM-ALK associated with anaplastic large cell lymphoma
18) Confidence 0.10 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.29 Pain Relevance 0.03
The IL-22 receptor, a heterodimer composed of IL-22R1 and IL-10R2, was expressed in all ALK(+)ALCL cell lines and tumors examined.
Gene_expression (expressed) of ALK associated with cancer and anaplastic large cell lymphoma
19) Confidence 0.09 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.25 Pain Relevance 0
Our results also corroborated the existence of such correlations between As concentration in blood and urine and the activities of these enzymes (negative with GSH, and positive with AST, ALT, AcP, AlkP and LPO).
Neg (negative) Gene_expression (negative) of AlkP in urine
20) Confidence 0.03 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.32 Pain Relevance 0

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