INT92398

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 11.24
Pain Relevance 5.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
nucleus 8
hepatocytes 4
HeLa 4
ganglion cell layer 3
plasma 2
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 3 99.68 Very High Very High Very High
Inflammation 72 98.88 Very High Very High Very High
Cannabinoid 1 97.80 Very High Very High Very High
cytokine 30 97.36 Very High Very High Very High
Pain 7 97.14 Very High Very High Very High
anesthesia 4 96.48 Very High Very High Very High
cINOD 21 96.46 Very High Very High Very High
Analgesic 3 96.24 Very High Very High Very High
aspirin 12 93.40 High High
dexamethasone 2 92.24 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 14 100.00 Very High Very High Very High
Necrosis 9 98.90 Very High Very High Very High
INFLAMMATION 84 98.88 Very High Very High Very High
Cancer 13 98.72 Very High Very High Very High
Apoptosis 6 98.72 Very High Very High Very High
Endotoxemia 1 98.32 Very High Very High Very High
Periarthritis 2 98.12 Very High Very High Very High
Nociception 1 95.20 Very High Very High Very High
Small Cell Lung Carcinoma 1 95.16 Very High Very High Very High
Ganglion Cysts 4 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
Negative_regulation (inhibited) of Localization (translocation) of NF-kB in nucleus associated with spinal cord
1) Confidence 0.42 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.45 Pain Relevance 0.51
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
Negative_regulation (inhibited) of Localization (translocation) of NF-kB in nucleus associated with spinal cord
2) Confidence 0.42 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.45 Pain Relevance 0.51
In further studies, NNU-hdpa was found to significantly inhibit the productions of PGE(2) and LTB(4) in LPS-challenged RAW 264.7, which is parallel to its prevention of the nuclear translocation of the NF-kappaB p50 and p65 subunits.
Negative_regulation (prevention) of Localization (translocation) of NF-kappaB in RAW 264
3) Confidence 0.40 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19345206 Disease Relevance 0.46 Pain Relevance 0.29
Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation.
Negative_regulation (suppressing) of Localization (translocation) of NF-kappaB in hepatocytes associated with cytokine
4) Confidence 0.39 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 18387647 Disease Relevance 0.30 Pain Relevance 0.32
Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-kappaB nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway.
Negative_regulation (suppressed) of Localization (translocation) of NF-kappaB in hepatocytes
5) Confidence 0.39 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.27 Pain Relevance 0.12
As hypothesized, S1627 prevented the zymosan-induced nuclear translocation of NF-kappaB in the spinal cord and the upregulation of NF-kappaB-responsive genes including cyclooxygenase-2, tumor necrosis factor-alpha, and IL-1beta.
Negative_regulation (prevented) of Localization (translocation) of NF-kappaB in spinal cord associated with necrosis, cancer and spinal cord
6) Confidence 0.38 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973242 Disease Relevance 1.50 Pain Relevance 0.85
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Negative_regulation (inhibited) of Localization (translocation) of NF-kappaB in ganglion cell layer associated with ganglion cysts and diabetes mellitus
7) Confidence 0.34 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.38 Pain Relevance 0.24
This complex prevents the translocation of NF-kB to the nucleus.
Negative_regulation (prevents) of Localization (translocation) of NF-kB in nucleus
8) Confidence 0.31 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.57 Pain Relevance 0.13
We further show that sulindac inhibits TNF-alpha-mediated activation of NF-kappaB DNA binding and nuclear translocation of NF-kappaB.
Negative_regulation (inhibits) of Localization (translocation) of NF-kappaB
9) Confidence 0.29 Published 2002 Journal Clin. Cancer Res. Section Abstract Doc Link 11839649 Disease Relevance 1.22 Pain Relevance 0.18
In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and IkappaBalpha, as well as the nuclear translocation of NF-kappaB primed by LPS.
Negative_regulation (attenuated) of Localization (translocation) of NF-kappaB
10) Confidence 0.28 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.31 Pain Relevance 0.19
Oxaprozin's strong analgesic qualities are particularly useful in painful musculoskeletal conditions such as periarthritis of the shoulder, since it exhibits actions such as inhibition of COX-1 and COX-2 isoenzymes, inhibition of nuclear translocation of NF-kappaB and of metalloproteases, and modulates the endogenous cannabinoid system.
Negative_regulation (inhibition) of Localization (translocation) of NF-kappaB in shoulder associated with pain, periarthritis, cannabinoid and analgesic
11) Confidence 0.20 Published 2004 Journal Curr Med Res Opin Section Abstract Doc Link 15324530 Disease Relevance 1.15 Pain Relevance 1.07
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Negative_regulation (inhibited) of in inner nuclear layer Localization (translocation) of NF-kappaB in ganglion cell layer associated with ganglion cysts and diabetes mellitus
12) Confidence 0.12 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.38 Pain Relevance 0.24
In this study, we show that ergolide suppresses the DNA binding activity of NF-kappaB and nuclear translocation of NF-kappaB p65 subunit, leading to the inhibition of NF-kappaB-dependent gene transcription in 12-O-tetradecanoylphorbol 13acetate (TPA)-stimulated HeLa cells.
Negative_regulation (suppresses) of Localization (translocation) of NF-kappaB in HeLa
13) Confidence 0.09 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17430640 Disease Relevance 0 Pain Relevance 0
In this study, we show that ergolide suppresses the DNA binding activity of NF-kappaB and nuclear translocation of NF-kappaB p65 subunit, leading to the inhibition of NF-kappaB-dependent gene transcription in 12-O-tetradecanoylphorbol 13acetate (TPA)-stimulated HeLa cells.
Negative_regulation (suppresses) of Localization (translocation) of NF-kappaB in HeLa
14) Confidence 0.09 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17430640 Disease Relevance 0 Pain Relevance 0
We recently observed that, differently from conventional anti-inflammatory drugs, E(2) stimulates a nongenomic event that interferes with the LPS signal transduction from the plasma membrane to cytoskeleton and intracellular effectors, which results in the inhibition of the nuclear translocation of NF-kappaB, a transcription factor of inflammatory genes.
Negative_regulation (inhibition) of Localization (translocation) of NF-kappaB in plasma associated with inflammation and cinod
15) Confidence 0.07 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17261778 Disease Relevance 0.95 Pain Relevance 0.47
P. asiatica blocked the translocation of NF-kappaB from the cytosol to the nucleus.
Negative_regulation (blocked) of Localization (translocation) of NF-kappaB in nucleus
16) Confidence 0.05 Published 2009 Journal J Med Food Section Abstract Doc Link 19735174 Disease Relevance 0.37 Pain Relevance 0.19
The novel nuclear factor (NF)-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) is a derivative of the antibiotic epoxyquinomicin C from Amycolatopsis sp. that has been found to inhibit tumour necrosis factor (TNF)-alpha-induced activation of NF-kappaB by suppressing nuclear translocation of NF-kappaB.
Negative_regulation (suppressing) of Localization (translocation) of NF-kappaB associated with necrosis and cancer
17) Confidence 0.03 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20337659 Disease Relevance 0.48 Pain Relevance 0.07

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